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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ubiquitination factor E4A

This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Glucagon, Insulin, HAD, CAN, DSP
Papers using E4 antibodies
GFAP in health and disease.
Mosley R. Lee, In PLoS ONE, 2010
... Peptides (GLP-1 and Ex-4) were obtained from AnaSpec (Fremont, CA) ...
MicroRNAs 103 and 107 regulate insulin sensitivity
Dzeja Petras, In PLoS ONE, 2010
... Anti-GLP-1-receptor was from Abcam (Cambridge, UK); anti-GLUT4 was ...
G protein coupled receptors as allosteric proteins and the role of allosteric modulators
Obukhov Alexander G., In PLoS ONE, 2009
... GLP-1 7–36 amide was purchased from Bachem (Weil am Rhein, Germany) ...
Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth.
Blagosklonny Mikhail V., In PLoS ONE, 2003
... Anti-P-ERK1/2 (anti-phospho-tyr-204, clone E4) was from Santa Cruz Biotechnology (Santa Cruz, CA), anti-ERK1/2 ...
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron
Klinge Petra M et al., In Cerebrospinal Fluid Research, 2002
... ) containing "native" (CB085) or GLP-1 transfected hMSCs (CB087) were stereotactically implanted into the right ventricle of double transgenic mice mutant expressing APP ...
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Papers on E4
Intestinal Bile Acid Composition Modulates Prohormone Convertase 1/3 (PC1/3) Expression and Consequent GLP-1 Production in male mice.
Itoh et al., Tokyo, Japan. In Endocrinology, Feb 2016
Although the mechanisms underlying these effects are still enigmatic, GLP-1 appears to be involved.
Puerarin protects pancreatic β-cells in obese diabetic mice via activation of GLP-1R signaling.
Shu et al., Nanjing, China. In Mol Endocrinol, Feb 2016
Further mechanism studies showed that the circulating level of GLP-1 in mice was unaffected by puerarin.
A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes.
Rayner et al., Adelaide, Australia. In Diabetes Care, Feb 2016
Compared with both PLBO/WHEY and VILD/CTRL, VILD/WHEY was associated with higher plasma intact GLP-1 and GIP, slower gastric emptying, and lower postprandial glycemia (P < 0.05 each).
GLP-1 based therapies: clinical implications for gastroenterologists.
Cahen et al., Amsterdam, Netherlands. In Gut, Feb 2016
UNASSIGNED: The gut-derived incretin hormone, glucagon-like peptide 1 (GLP-1) lowers postprandial blood glucose levels by stimulating insulin and inhibiting glucagon secretion.
Effects of endogenous GLP-1 and GIP on glucose tolerance after Roux-en-Y gastric bypass surgery.
Madsbad et al., Copenhagen, Denmark. In Am J Physiol Endocrinol Metab, Feb 2016
UNASSIGNED: Exaggerated secretion of glucagon-like peptide 1 (GLP-1) is important for postprandial glucose tolerance after Roux-en-Y gastric bypass (RYGB), whereas the role of glucose-dependent insulinotropic polypeptide (GIP) remains to be resolved.
Drug development from the bench to the pharmacy: with special reference to dipeptidyl peptidase-4 inhibitor development.
Carr, Ballerup, Denmark. In Diabet Med, Feb 2016
Glucagon-like peptide 1 (GLP-1), a hormone with a spectrum of favourable metabolic actions, including glucose-dependent stimulation of insulin and inhibition of glucagon secretion, provided the endocrine basis from which the idea of using DPP-4 inhibitors as anti-diabetic agents was developed.
IDegLira: Redefining insulin optimisation using a single injection in patients with type 2 diabetes.
Hughes, Ryde, United Kingdom. In Prim Care Diabetes, Feb 2016
With complementary modes of action, glucagon-like peptide-1 receptor agonists (GLP-1RAs) and a basal insulin in combination offer an alternative to basal-bolus therapy in T2D.
TCF1 links GIPR signaling to the control of beta cell function and survival.
Drucker et al., Toronto, Canada. In Nat Med, Jan 2016
The glucagon-like peptide-1 (GLP-1) receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor transduce nutrient-stimulated signals to control beta cell function.
Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants.
Langmead et al., Australia. In Plos One, Dec 2015
Using cell signalling, and glucagon-like peptide (GLP)-1 and insulin release assays, our results confirm that basic L-amino acids act as agonists of the murine GPRC6A receptor in both recombinant cells and immortalised entero-endocrine and pancreatic β-cells.
Pleiotropic effects of insulin and GLP-1 receptor agonists: Potential benefits of the association.
Cariou, Nantes, France. In Diabetes Metab, Dec 2015
However, GLP-1 receptors (GLP-1Rs) are widely expressed in extrapancreatic tissues and could sustain pleiotropic actions of GLP-1RAs beyond glycaemic control.
Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Lam et al., Toronto, Canada. In Nat Med, May 2015
Inhibition of duodenal Ampk negated the HGP-lowering effect of intraduodenal metformin, and both duodenal glucagon-like peptide-1 receptor (Glp-1r)-protein kinase A (Pka) signaling and a neuronal-mediated gut-brain-liver pathway were required for metformin to lower HGP.
Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease.
D'Alessio et al., Cincinnati, United States. In Physiol Rev, Apr 2015
Of these, glucagon and GLP-1 have received the most attention because of important roles in glucose metabolism, involvement in diabetes and other disorders, and application to therapeutics.
GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.
Drucker et al., Toronto, Canada. In Cell Metab, Apr 2015
Glucagon-like peptide-1 (GLP-1) secreted from enteroendocrine L cells promotes nutrient disposal via the incretin effect.
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Tschöp et al., München, Germany. In Nat Med, 2015
We report the discovery of a new monomeric peptide that reduces body weight and diabetic complications in rodent models of obesity by acting as an agonist at three key metabolically-related peptide hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptors.
Medicinal Plants Qua Glucagon-Like Peptide-1 Secretagogue via Intestinal Nutrient Sensors.
Jang et al., Seoul, South Korea. In Evid Based Complement Alternat Med, 2014
Glucagon-like peptide-1 (GLP-1) participates in glucose homeostasis and feeding behavior.
EHMT1 protein binds to nuclear factor-κB p50 and represses gene expression.
Baltimore et al., Kuala Lumpur, Malaysia. In J Biol Chem, 2012
EHMT1 protein binds to nuclear factor-kappaB p50 and represses gene expression.
Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability.
van Bokhoven et al., Nijmegen, Netherlands. In Am J Hum Genet, 2012
Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability.
Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.
Lee et al., In Pathology, 2011
we found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability
Characterization of a novel transcript of the EHMT1 gene reveals important diagnostic implications for Kleefstra syndrome.
Kleefstra et al., Nijmegen, Netherlands. In Hum Mutat, 2011
These results have important implications for the genetic screening of Kleefstra syndrome and for studies of the functional significance of EHMT1.
A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells.
Spinette et al., Baltimore, United States. In Plos One, 2010
The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis.
More papers using E4 antibodies
Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells
Figdor Carl G. et al., In The Journal of Cell Biology, 1998
... For detection of CD46 and CD55 the Abs E4.3 (BD Biosciences) and 143–30 (CLB) were ...
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