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E2F transcription factor 8

E2F8, transcription factor E2F8, E2F transcription factor 8
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: E2F7, E2F1, CAN, MSP, E2F6
Papers on E2F8
E2F8 as a Novel Therapeutic Target for Lung Cancer.
Koo et al., New Haven, United States. In J Natl Cancer Inst, Sep 2015
BACKGROUND: The E2F members have been divided into transcription activators (E2F1-E2F3) and repressors (E2F4-E2F8).
Mature T cell responses are controlled by microRNA-142.
Reddy et al., In J Clin Invest, Aug 2015
Moreover, 2 predicted miR-142 target genes, the atypical E2F transcription factors E2f7 and E2f8, were most highly upregulated in miR-142-deficient cells.
Bikfalvi et al., In Ukr Biochem J, Mar 2015
We studied the effect of hypoxia on the expression of genes encoding the transcription factors such as E2F8 (E2F transcription factor 8), EPAS1 (endothelial PAS domain protein 1), TBX3 (T-box 3), ATF3 (activating transcription factor 3), FOXF1 (forkhead box F), and HOXC6 (homeobox C6) in U87 glioma cells with and without ERN1 signaling enzyme function.
Structural insights into the DNA-binding specificity of E2F family transcription factors.
Taipale et al., Stockholm, Sweden. In Nat Commun, 2014
Typical E2Fs bind to DNA as heterodimers with the related dimerization partner (DP) proteins, whereas the atypical E2Fs, E2F7 and E2F8 contain two DNA-binding domains (DBDs) and act as repressors.
Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway.
Bjørås et al., Oslo, Norway. In Sci Rep, 2014
HIF1A, SP6, E2F8 and TCF3), antioxidant genes (PRDX4, PTGS1 and CYGB) and numerous genes of the p53 signaling pathway involved in cell-cycle arrest (i.e.
E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish.
Tanaka et al., Tsu, Japan. In Nutr Metab (lond), 2014
E2f8 MO i.p. suppressed fabp3 expression in liver, and ameliorated hepatic steatosis.
Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.
Yang et al., Guangzhou, China. In Cell Cycle, 2014
Here we report a novel role of E2F8 in the polyploidization of decidual cells in mice.
Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation.
Wu et al., Newark, United States. In Mol Cell Biol, 2014
Importantly, all of these defects associated with Rb loss were exacerbated by the concomitant inactivation of E2f8.
Promising roles of mammalian E2Fs in hepatocellular carcinoma.
Li et al., Hefei, China. In Cell Signal, 2014
Eight members, E2F1 E2F8 have been recognized of this family so far, and the members of this family are generally divided into activator E2F (E2F1--E2F3a), repressor E2F (E2F3b--E2F5) and inhibitor E2F (E2F6--E2F8) subclasses based on their structur-e and function.
Bortezomib effect on E2F and cyclin family members in human hepatocellular carcinoma cell lines.
Grassi et al., Trieste, Italy. In World J Gastroenterol, 2014
Using small interfering RNA's, the effects of E2F8 depletion on cell number was also evaluated.
E2F transcription factors and digestive system malignancies: how much do we know?
Tiniakos et al., Norway. In World J Gastroenterol, 2013
E2F8 is strongly upregulated in human HCC, thus possibly contributing to hepatocarcinogenesis. Adenoviral transfer of E2F as gene therapy to sensitize pancreatic cancer cells for chemotherapeutic agents has been used in experimental studies.
Atypical E2fs control lymphangiogenesis through transcriptional regulation of Ccbe1 and Flt4.
de Bruin et al., Utrecht, Netherlands. In Plos One, 2012
In the case of angiogenesis, atypical E2fs (E2f7 and E2f8) however have been recently shown to function as transcriptional activators for VegfA.
Canonical and atypical E2Fs regulate the mammalian endocycle.
Leone et al., Columbus, United States. In Nat Cell Biol, 2012
Using lineage-specific cre mice we identified two opposing arms of the E2F program, one driven by canonical transcription activation (E2F1, E2F2 and E2F3) and the other by atypical repression (E2F7 and E2F8), that converge on the regulation of endocycles in vivo.
E2F8 is essential for polyploidization in mammalian cells.
de Bruin et al., Utrecht, Netherlands. In Nat Cell Biol, 2012
Here, we show in mice that atypical E2F8 is induced after weaning and required for hepatocyte binucleation and polyploidization.
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Wu et al., Newark, United States. In Blood, 2012
The specificity of E2F8 in mediating Rb function in erythropoiesis suggests a critical and overlapping roles of Rb and E2f8 in maintaining normal erythropoiesis and in preventing hemolysis.
E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation.
Han et al., Shanghai, China. In Cancer Res, 2010
Analyses indicated that E2F8 could bind to regulatory elements of cyclin D1, regulating its transcription and promoting accumulation of S-phase cells. Findings suggest that E2F8 contributes to the oncogenic potential of HCC
DNA-damage response control of E2F7 and E2F8.
La Thangue et al., Oxford, United Kingdom. In Embo Rep, 2008
E2F7 and E2F8 act upstream of E2F1, and influence the ability of cells to undergo a DNA-damage response.
Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
de Bruin et al., Columbus, United States. In Dev Cell, 2008
Results identify E2F7 and E2F8 as a unique repressive arm of the E2F transcriptional network that is critical for embryonic development.
Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis.
Johnson et al., Aurora, United States. In Curr Mol Med, 2006
E2F proteins are encoded by at least eight genes, E2F1 through E2F8.
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.
Helin et al., Copenhagen, Denmark. In Nucleic Acids Res, 2004
E2F8 may have an important role in repressing the expression of E2F-target genes in the S-phase of the cell cycle.
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