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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Branched chain ketoacid dehydrogenase E1, alpha polypeptide

plays a role in the conversion of 3-methyl-2-oxobutanoate and lipoamide to S-(2-methylpropanoyl)dihydrolipoamide and CO2 [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, p53, V1a, p300, HAD
Papers using E1A antibodies
Characterization of ST13 Protein Expression in Human Colorectal Cancer Tissues
Han Zhaozhong, In PLoS ONE, 2004
... The oncolytic viruses Ad·(EGFP)·CEA·E1A(Δ24) and Ad·(ST13)·CEA·E1A(Δ24) were generated by homologous recombination between pAd·(EGFP)·CEA·E1A(Δ24) or pAd·(ST13)·CEA·E1A(Δ24) with the adenovirus packaging plasmid pBHGE3 (Microbix Biosystem) in HEK293 cells using the effectene transfection reagent (Qiagen, Hilden, Germany) according to ...
Papers on E1A
Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation.
Sui et al., Winston-Salem, United States. In J Mol Cell Biol, Feb 2016
These residues are also involved in YY1 interaction with Mdm2, Ezh2, and E1A, and thus are designated as the oncogene protein binding (OPB) domain.
p300 is not required for metabolic adaptation to endurance exercise training.
Schenk et al., San Diego, United States. In Faseb J, Jan 2016
UNASSIGNED: The acetyltransferase, E1a-binding protein (p300), is proposed to regulate various aspects of skeletal muscle development, metabolism, and mitochondrial function, via its interaction with numerous transcriptional regulators and other proteins.
Glycoproteomic Approach Identifies KRAS as a Positive Regulator of CREG1 in Non-small Cell Lung Cancer Cells.
Mao et al., Baltimore, United States. In Theranostics, Dec 2015
Further investigation of a panel of NSCLC cell lines found that Cellular repressor of E1A-stimulated genes (CREG1) overexpression was closely correlated with KRAS mutation status in NSCLC cells and could be down-regulated by inhibition of KRAS expression.
Enhanced OCT4 transcriptional activity substitutes for exogenous SOX2 in cellular reprogramming.
Tapia et al., Münster, Germany. In Sci Rep, Dec 2015
Adenoviral early region 1A (E1A) is a viral gene that can promote cellular proliferation and de-differentiation in mammalian cells, features required for the reprogramming of somatic cells to a pluripotent state.
DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway.
Stetson et al., Seattle, United States. In Science, Nov 2015
Here, we identify the oncogenes of the DNA tumor viruses, including E7 from human papillomavirus (HPV) and E1A from adenovirus, as potent and specific inhibitors of the cGAS-STING pathway.
[Rescue and Amplification of Recombinant Human Adenovirus Type 41 in 293 Cells].
Hong et al., In Bing Du Xue Bao, Sep 2015
That is, the E3 coding sequence of HAdV-41 was deleted and replaced with the HAdV-5 E4orf6 gene; and the E1A enhancer of HAdV-5 was inserted upstream of the E4 promoter of HAdV-41.
C-terminal binding proteins: central players in development and disease.
Linseman et al., In Biomol Concepts, 2014
C-terminal binding proteins (CtBPs) were initially identified as binding partners for the E1A-transforming proteins.
Rubinstein-Taybi syndrome: clinical features, genetic basis, diagnosis, and management.
Esposito et al., Milano, Italy. In Ital J Pediatr, 2014
It has been shown that mutations in the genes encoding the cyclic-AMP-regulated enhancer binding protein (CREBBP) and the E1A-binding protein p300 (EP300) contributed to the development of RSTS.
The anti-tumor activity of E1A and its implications in cancer therapy.
Su et al., Taipei, Taiwan. In Arch Immunol Ther Exp (warsz), 2014
The adenovirus type 5 E1A protein (E1A) plays a critical role in anti-cancer gene therapy and has been tested in clinical trials.
Innate immunity to adenovirus.
Greber et al., Zürich, Switzerland. In Hum Gene Ther, 2014
Adenovirus tunes the function of antiviral autophagy, and counters innate defense by virtue of its early proteins E1A, E1B, E3, and E4 and two virus-associated noncoding RNAs VA-I and VA-II.
Review: R28 retinal precursor cells: the first 20 years.
Seigel, Buffalo, United States. In Mol Vis, 2013
The R28 retinal precursor cell line was established 20 years ago, originating from a postnatal day 6 rat retinal culture immortalized with the 12S E1A (NP-040507) gene of the adenovirus in a replication-incompetent viral vector.
Modulation of allostery by protein intrinsic disorder.
Deniz et al., Los Angeles, United States. In Nature, 2013
The adenovirus early region 1A (E1A) oncoprotein is a prime example of a molecular hub intrinsically disordered protein.
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.
Chua et al., Stanford, United States. In Nature, 2012
Moreover, SIRT7 is necessary for a global hypoacetylation of H3K18Ac associated with cellular transformation by the viral oncoprotein E1A.
Proapoptotic function of the retinoblastoma tumor suppressor protein.
Lees et al., Cambridge, United States. In Cancer Cell, 2009
Here we show that DNA damage and E1A-induced oncogenic stress promote formation of a pRB-E2F1 complex even in proliferating cells.
Endoreduplication in maize endosperm: involvement of m phase--promoting factor inhibition and induction of s phase--related kinases.
Larkins et al., In Science, 1995
Induction of DNA synthesis during early stages of endosperm development is maintained by increasing the amount and activity of S phase-related protein kinases, which was demonstrated here by their ability to interact with human E2F or with the adenovirus E1A proteins.
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