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Fatty acid binding protein 5

E-FABP, FABP5, Fatty acid-binding protein
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: ACID, FABP, H-FABP, fibrillin-1, HAD
Papers on E-FABP
Proteomic analysis of the INS-1E secretome identify novel vitamin D-regulated proteins.
Thorsby et al., Oslo, Norway. In Diabetes Metab Res Rev, Feb 2016
Moreover, modulations of several proteins implicated in prohormone processing and insulin exocytosis (IGF2, IGFBP7, Scg5, ProSAAS, Fabp5, Ptprn2 and gelsolin) appears to support the hypothesis that 1,25-(OH)2 D3 play positive modulatory role in insulin processing and secretion.
Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses.
Cataltepe et al., Boston, United States. In Angiogenesis, Jan 2016
FABP4 and FABP5 share ~55 % amino acid sequence homology and demonstrate synergistic effects in regulation of metabolic and inflammatory responses in adipocytes and macrophages.
Fatty acid binding protein 5 (FABP5) modulates docosahexaenoic acid (DHA)-induced recovery in rats undergoing spinal cord injury.
De Leon et al., Loma Linda, United States. In J Neurotrauma, Jan 2016
The objective of the present study was to determine the spatiotemporal expression of the fatty acid binding protein 5 (FABP5) following contusive SCI and to investigate whether this protein plays a role in n-3 PUFAs-mediated functional recovery after SCI.
Seasonal proteome changes of nasal mucus reflect perennial inflammatory response and reduced defence mechanisms and plasticity in allergic rhinitis.
Lang-Loidolt et al., Graz, Austria. In J Proteomics, Jan 2016
In healthy controls UBC, TUBA1B, HBB and FABP5 were only present in season.
Reduction of circulating FABP4 level by treatment with omega-3 fatty acid ethyl esters.
Miura et al., Sapporo, Japan. In Lipids Health Dis, Dec 2015
BACKGROUND: Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) mainly expressed in adipocytes is secreted and acts as an adipokine.
Tissue expression analysis, cloning, and characterization of the 5'-regulatory region of the bovine fatty acid binding protein 4 gene.
Zan et al., In J Anim Sci, Nov 2015
Fatty acid binding protein 4 (FABP4) is a member of the FABP family of proteins that bind fatty acids and play important roles in fatty acid uptake and intracellular transport.
Metabolic functions of FABPs--mechanisms and therapeutic implications.
Bernlohr et al., Boston, United States. In Nat Rev Endocrinol, Oct 2015
In particular, genetic deficiency and small molecule-mediated inhibition of FABP4 (also known as aP2) and FABP5 can potently improve glucose homeostasis and reduce atherosclerosis in mouse models.
Epidermal Fatty Acid binding protein promotes skin inflammation induced by high-fat diet.
Li et al., Austin, United States. In Immunity, Jun 2015
Mechanistically, epidermal fatty acid binding protein (E-FABP) was significantly upregulated in skin of obese mice, which coupled lipid droplet formation and NLRP3 inflammasome activation.
Prawn Shell Chitosan Has Anti-Obesogenic Properties, Influencing Both Nutrient Digestibility and Microbial Populations in a Pig Model.
O'Doherty et al., Dublin, Ireland. In Plos One, 2014
Fatty acid binding protein 2 (FABP2) gene expression was down-regulated in pigs offered chitosan (P = 0.05) relative to the basal diet.
Fatty acid binding proteins 4 and 5 in overweight prepubertal boys: effect of nutritional counselling and supplementation with an encapsulated fruit and vegetable juice concentrate.
Balagopal et al., Jacksonville, United States. In J Nutr Sci, 2014
The aim of this post hoc study was to determine the effect of overweight (OW) on FABP4 and FABP5 in boys in relation to indices of adiposity, insulin resistance and inflammation, and to investigate the effects of a 6-month supplementation with an encapsulated fruit and vegetable juice concentrate (FVJC) plus nutritional counselling (NC) on FABP levels.
Fatty acid binding proteins and the nervous system: Their impact on mental conditions.
Osumi et al., Wako, Japan. In Neurosci Res, 2014
Among Fabp family molecules, Fabp3, Fabp5, and Fabp7 are specifically localized in neural stem/progenitor cells, neurons and glia in a cell-type specific manner.
Small molecule inhibitors of human adipocyte fatty acid binding protein (FABP4).
Li et al., Shanghai, China. In Med Chem, 2014
Fatty acid binding protein 4 (FABP4) is expressed in adipocytes and macrophages, and modulates inflammatory and metabolic response.
Fatty acid binding proteins: tissue-specific functions in health and disease.
Plant et al., Guildford, United Kingdom. In Curr Opin Clin Nutr Metab Care, 2014
RECENT FINDINGS: Dysregulated FABPs have been associated with a number of diseases, including obesity and nonalcoholic fatty liver disease (FABP1, FABP2, FABP4), cardiovascular risk (FABP3) and cancer (FABP5, FABP7).
Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases.
Miura et al., Sapporo, Japan. In Clin Med Insights Cardiol, 2013
Fatty acid-binding protein 4 (FABP4), also known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation.
The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse.
Osumi et al., Sendai, Japan. In Stem Cells, 2012
The data suggest that Fabp7 and Fabp5 have differential roles for proliferation and survival of the NSCs/NPCs during postnatal dentate gyrus neurogenesis.
Molecular determinants of retinoic acid sensitivity in pancreatic cancer.
Maitra et al., Baltimore, United States. In Clin Cancer Res, 2012
High FABP5 is associated with pancreatic ductal adenocarcinoma.
Different association of circulating levels of adipocyte and epidermal fatty acid-binding proteins with metabolic syndrome and coronary atherosclerosis in Chinese adults.
Ning et al., Shanghai, China. In Atherosclerosis, 2011
while both serum A-FABP and E-FABP levels are associated with MetS, only A-FABP is significantly associated with increased risk of CAD in Chinese adults
Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes.
Linton et al., Nashville, United States. In Arterioscler Thromb Vasc Biol, 2011
Mal1 plays a proatherogenic role by suppressing PPARgamma activity, which increases expression of CC chemokine receptor 2 by monocytes, promoting their recruitment to atherosclerotic lesions.
Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy.
Godbout et al., Edmonton, Canada. In Am J Pathol, 2011
The purpose of this study was to investigate the clinicopathological significance of FABP5 in breast cancer and to evaluate FABP5 as a prognostic marker and a possible novel therapeutic target in breast cancer.
Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors.
Noy et al., Ithaca, United States. In Cell, 2007
Partitioning of RA between the two receptors is regulated by the intracellular lipid binding proteins CRABP-II and FABP5.
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