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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Dual specificity phosphatase 22

Top mentioned proteins: JNK, ALK, CD30, HAD, MUM1
Papers on DUSP22
Morphologic Features of ALK-negative Anaplastic Large Cell Lymphomas With DUSP22 Rearrangements.
Feldman et al., Durham, United States. In Am J Surg Pathol, Jan 2016
The largest subset, representing 30% of cases, had rearrangements of the DUSP22 locus.
Molecular Pathogenesis of Peripheral T Cell Lymphoma.
Chiba et al., Tsukuba, Japan. In Curr Hematol Malig Rep, Dec 2015
For example, genetic alterations have been discovered, including signal transducer and activator of transcription (STAT)3 and STAT5b mutations in several PTCLs, disease-specific ras homolog family member A (RHOA) mutations in angioimmunoblastic T cell lymphoma (AITL), and recurrent translocations at the dual specificity phosphatase 22 (DUSP22) locus in anaplastic lymphoma receptor tyrosine kinase (ALK)-negative anaplastic large cell lymphomas (ALCLs).
Decreased expression of dual specificity phosphatase 22 in colorectal cancer and its potential prognostic relevance for stage IV CRC patients.
Zhang et al., Hangzhou, China. In Tumour Biol, Nov 2015
Dual specificity phosphatase 22 (DUSP22) is a novel dual specificity phosphatase that has been demonstrated to be a cancer suppressor gene associated with numerous biological and pathological processes.
Expression of the chemokine receptor gene, CCR8, is associated With DUSP22 rearrangements in anaplastic large cell lymphoma.
Feldman et al., Binghamton, United States. In Appl Immunohistochem Mol Morphol, Sep 2015
We recently identified recurrent rearrangements of the DUSP22 locus on 6p25.3 in both primary cutaneous and systemic ALK-negative ALCLs.
The biology and management of systemic anaplastic large cell lymphoma.
Savage et al., Vancouver, Canada. In Blood, Aug 2015
However, emerging data now highlight that ALK- ALCL is genetically and clinically heterogeneous with a subset having either a DUSP22 translocation and a survival rate similar to ALK+ ALCL or a less common P63 translocation, the latter associated with an aggressive course.
Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases.
Beylot-Barry et al., Pessac, France. In Br J Dermatol, Jun 2015
DUSP22 gene rearrangement had no diagnostic or prognostic value.
Primary cutaneous anaplastic large cell lymphomas with 6p25.3 rearrangement exhibit particular histological features.
Piris et al., Santander, Spain. In Histopathology, May 2015
DUSP22-IRF4 locus translocation is present in 20-57% of C-ALCLs, and has also been described in a series of 11 lymphomatoid papulosis patients, where it was associated with a particular biphasic histological pattern, including pagetoid reticulosis-type epidermal infiltration.
Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate.
Waugh et al., Frederick, United States. In Acta Crystallogr Sect F Struct Biol Commun, Feb 2015
Here, the first crystal structure is presented of a dual-specificity phosphatase, human dual-specificity phosphatase 22 (DUSP22), in complex with pNPP.
Anaplastic large cell lymphomas: ALK positive, ALK negative, and primary cutaneous.
Feldman et al., Qingdao, China. In Adv Anat Pathol, 2015
A subset of ALK-negative ALCLs has rearrangements in or near the DUSP22 gene and has a favorable prognosis similar to that of ALK-positive ALCL.
Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases.
Ulrich et al., Frederick, United States. In Plos One, 2014
We investigated the interactions of peptide substrates with select DUSPs of four types: MAP kinases (DUSP1 and DUSP7), atypical (DUSP3, DUSP14, DUSP22 and DUSP27), viral (variola VH1), and Cdc25 (A-C).
Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: expanding the spectrum of CD30-positive lymphoproliferative disorders.
Gratzinger et al., Rochester, United States. In Am J Surg Pathol, 2014
The clinical and pathologic characteristics of the CD30 TLPDs were similar to those of their extravascular counterparts, including extralymphatic dermal involvement in a subset, DUSP22-IRF4 translocations in half of tested ALK ALCLs, and associated mycosis fungoides in 1; most were skin-limited at baseline and remained so at relapse.
ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes.
Feldman et al., Rochester, United States. In Blood, 2014
Chromosomal rearrangements of DUSP22 and TP63 were identified in 30% and 8% of ALK-negative ALCLs, respectively.
The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck.
Tan et al., Taiwan. In Nat Commun, 2013
JNK pathway-associated phosphatase (JKAP, also known as DUSP22 or JSP-1) is a JNK activator.
Genome-wide DNA methylation profiles according to Chlamydophila psittaci infection and the response to doxycycline treatment in ocular adnexal lymphoma.
Khwarg et al., Seoul, South Korea. In Mol Vis, 2013
Among the 180 DMGs, DUSP22, which had two significantly hypomethylated loci, was validated, and the correlation was significant for one CpG site (Spearman coefficient=0.6478,
New biomarkers in T-cell lymphomas.
de Leval et al., Li├Ęge, Belgium. In Best Pract Res Clin Haematol, 2012
Previously unrecognized gene rearrangements are being discovered (ITK-SYK translocation, IRF4/MUM1 and DUSP22 rearrangements), and may serve as diagnostic genetic markers.
Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing.
Vasmatzis et al., Rochester, United States. In Blood, 2011
Data show that t(6;7)(p25.3;q32.3) was associated with down-regulation of DUSP22 and up-regulation of MIR29 microRNAs on 7q32.3.
JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.
Tan et al., Taiwan. In J Biol Chem, 2010
a new role for JKAP in the modulation of FAK phosphorylation and cell motility.
DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.
Matsuda et al., Sapporo, Japan. In Oncogene, 2007
DUSP22 acts as a negative regulator of the estrogen receptor alpha-mediated signaling pathway in breast cancer cells.
Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution.
Sugio et al., Yokohama, Japan. In Proteins, 2007
The crystal structre showed 1 domain with 6 alpha helices & 5 beta strans, a PTP-loop at the active site binding MES, and an Ala instead of a Trp at the substrate-stacking loop.
Regulation of STAT3-mediated signaling by LMW-DSP2.
Matsuda et al., Sapporo, Japan. In Oncogene, 2006
DSP2 acts as a negative regulator of the IL-6/LIF/STAT3-mediated signaling pathway.
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