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Dual oxidase 1

Duox1, Duox, nicotinamide adenine dinucleotide phosphate oxidase, dual oxidase, dual oxidase 1
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ros, DUOX2, V1a, CAN, HAD
Papers on Duox1
Natural course of congenital hypothyroidism by dual oxidase 2 mutations from the neonatal period through puberty.
Takeuchi et al., Niigata, Japan. In Eur J Endocrinol, Feb 2016
OBJECTIVE: We previously reported that biallelic mutations in dual oxidase 2 (DUOX2) cause transient hypothyroidism.
Statins and oxidative stress in chronic heart failure.
Sousa et al., Porto, Portugal. In Rev Port Cardiol, Feb 2016
By regulating several molecular pathways that control nicotinamide adenine dinucleotide phosphate oxidase and endothelial nitric oxide synthase activity, statins help restore redox homeostasis.
Impact of the blood meal on humoral immunity and microbiota in the gut of female Culicoides sonorensis.
Saski et al., Manhattan, United States. In Vet Ital, Jan 2016
Blood feeding altered the transcription of several humoral immune components of the Immune deficiency (Imd), dual‑oxidase (DUOX), and Janus Kinase and Signal Transducer and Activator of Transcription (JAK/STAT) pathways.
TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway.
Kang et al., Suwŏn, South Korea. In Plos Genet, Jan 2016
In Drosophila melanogaster, dual oxidase (Duox) kills pathogenic microbes by generating the microbicidal reactive oxygen species (ROS), hypochlorous acid (HOCl) in response to bacterially excreted uracil.
Novel c.554+5C>T Mutation in the DUOXA2 gene Combinated with p.R885Q Mutation in the DUOX2 Gene Causes Congenital Hypothyroidism.
Shao et al., In J Clin Res Pediatr Endocrinol, Jan 2016
OBJECTIVE: The coexistence of mutations in the dual oxidase maturation factor 2 (DUOXA2) and dual oxidase 2 (DUOX2) genes is rarely identified in congenital hypothyroidism (CH).
The human Nox4: gene, structure, physiological function and pathological significance.
Chen et al., Aomen, Macao. In J Drug Target, Dec 2015
Nox4, one of the seven members of Nox family (Nox1, Nox2, Nox3, Nox4, Nox5, Duox1 and Duox2), has been extensively investigated in recent years.
Congenital hypothyroidism: recent advances.
Brown et al., Boston, United States. In Curr Opin Endocrinol Diabetes Obes, Oct 2015
Recent studies of defects in thyroid hormone synthesis have focused on the role of mutations in the dual oxidase system and of a novel apical iodide transporter, anoctamin 1.
Blood flow modulation of vascular dynamics.
Hsiai et al., Los Angeles, United States. In Curr Opin Lipidol, Oct 2015
Atheroprotective PSS promotes antioxidant, anti-inflammatory and antithrombotic responses, whereas atherogenic oscillatory shear stress induces nicotinamide adenine dinucleotide phosphate oxidase-JNK signalling to increase mitochondrial superoxide production, protein degradation of manganese superoxide dismutase and post-translational protein modifications of LDL particles in the disturbed flow-exposed regions of vasculature.
The blood-brain barrier endothelium: a target for pro-inflammatory cytokines.
Cummins et al., Dublin, Ireland. In Biochem Soc Trans, Sep 2015
The mechanistic role of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase)-induced oxidative stress in these events will also be addressed.
Organ-Protective Effects of Red Wine Extract, Resveratrol, in Oxidative Stress-Mediated Reperfusion Injury.
Yu et al., Taiwan. In Oxid Med Cell Longev, 2014
Such protective phenomenon is reported to be implicated in decreasing the formation and reaction of reactive oxygen species and pro-nflammatory cytokines, as well as the mediation of a variety of intracellular signaling pathways, including the nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase, deacetylase sirtuin 1, mitogen-activated protein kinase, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha, hemeoxygenase-1, and estrogen receptor-related pathways.
Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila.
Lee et al., Seoul, South Korea. In Cell, 2013
Here, we show that bacterial-derived uracil acts as a ligand for dual oxidase (DUOX)-dependent reactive oxygen species generation in Drosophila gut and that the uracil production in bacteria causes inflammation in the gut.
NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.
Yuan et al., Guangzhou, China. In Tumour Biol, 2011
Data show that comparing with adjacent non-neoplastic tissues, DUOX1, DUOX2, and NOX4 were expressed at higher frequencies in tumor specimens.
Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila.
McGinnis et al., San Diego, United States. In Plos Genet, 2011
One gene required to activate epidermal wound reporters encodes Dual oxidase, an enzyme that produces hydrogen peroxide.
Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.
Avvedimento et al., Napoli, Italy. In Plos One, 2011
study reports DUOX 1 and 2 are expressed in neuroblastoma SK-N-BE cells as well as in an oligodendrocyte cell line (MO3-13); data unravel a novel mechanism of regulation of DUOX enzymes by reactive oxygen species and identify a circuitry linking NADPH oxidase activity to DUOX1 and 2 levels in neuroblastoma cells
Essential role of Duox in stabilization of Drosophila wing.
Kamei et al., Kyoto, Japan. In J Biol Chem, 2011
dDuox plays important roles in the stabilization of the cuticle structure of the wings.
Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes.
Aiba et al., Sendai, Japan. In J Immunol, 2011
Data demonstrated that the increased expression of DUOX1 in IL-4/IL-13-treated NHEK augments STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B.
A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae.
Barillas-Mury et al., Rockville, United States. In Science, 2010
We show that a peroxidase, secreted by the Anopheles gambiae midgut, and dual oxidase form a dityrosine network that decreases gut permeability to immune elicitors.
Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut.
Lee et al., Seoul, South Korea. In Nat Immunol, 2009
Here we identify a signaling network composed of complex positive and negative mechanisms that controlled the expression and activity of dual oxidase (DUOX), which 'fine tuned' the production of microbicidal reactive oxygen species depending on whether the gut encountered infectious or commensal microbes.
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish.
Mitchison et al., Boston, United States. In Nature, 2009
Using pharmacological and genetic inhibition, we show that this gradient is created by dual oxidase (Duox), and that it is required for rapid recruitment of leukocytes to the wound.
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.
Krause et al., Genève, Switzerland. In Physiol Rev, 2007
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2.
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