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Ubiquitin specific peptidase 36

DUB-1, Deubiquitinating Enzyme, USP36
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP36 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jan 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, ACID, SBS, V1a
Papers on DUB-1
Deubiquitinating c-Myc: USP36 steps up in the nucleolus.
Dai et al., Portland, United States. In Cell Cycle, Jan 2016
We recently found the nucleolar USP36 as a novel c-Myc deubiquitinase that controls the end-point of c-Myc degradation pathway in the nucleolus.
Deubiquitinating enzyme USP37 regulating oncogenic function of 14-3-3γ.
Baek et al., South Korea. In Oncotarget, Dec 2015
14-3-3 is a family of highly conserved protein that is involved in a number of cellular processes.
Regulation of E2 Promoter Binding Factor 1 (E2F1) Transcriptional Activity through a Deubiquitinating Enzyme, UCH37.
Lin et al., Houston, United States. In J Biol Chem, Nov 2015
Here we identify UCH37 as the first, to our knowledge, deubiquitinating enzyme for E2F1.
USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.
Zhang et al., Nantong, China. In J Mol Neurosci, Oct 2015
UNASSIGNED: Protein ubiquitination is a dynamic two-way process that can be reversed or regulated by deubiquitinating enzymes (DUB).
The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin.
Shirahige et al., Tokyo, Japan. In J Biol Chem, Sep 2015
To better understand the mechanism of AR transcriptional activity regulation, we used antibodies against AR for affinity purification and identified the deubiquitinating enzyme ubiquitin-specific protease 7, USP7 as a novel AR co-regulator in prostate cancer cells.
A Conserved Deubiquitinating Enzyme Uses Intrinsically Disordered Regions to Scaffold Multiple Protein Interaction Sites.
Gardner et al., Seattle, United States. In J Biol Chem, Sep 2015
Here, we characterize a yeast deubiquitinating enzyme, Ubp10, that possesses IDRs flanking its catalytic protease domain.
Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2.
Cui et al., Jinan, China. In J Mol Cell Cardiol, Jul 2015
Ubiquitin proteasome system (UPS) consists of ubiquitin, ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), ubiquitin ligases (E3s), proteasomes, and deubiquitinating enzymes (DUBs).
The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila.
Taillebourg et al., Grenoble, France. In Plos One, 2014
Autophagy is a catabolic process that delivers cytoplasmic components to the lysosomes.
Peroxisomal Import Reduces the Proapoptotic Activity of Deubiquitinating Enzyme USP2.
Erdmann et al., Bochum, Germany. In Plos One, 2014
The human deubiquitinating enzyme ubiquitin-specific protease 2 (USP2) regulates multiple cellular pathways, including cell proliferation and apoptosis.
Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1.
Dai et al., Portland, United States. In World J Biol Chem, 2014
Interestingly, Otub1 abrogates p53 ubiquitination and stabilizes and activates p53 in cells independently of its deubiquitinating enzyme activity.
Deubiquitinating enzyme inhibitors and their potential in cancer therapy.
Crosas, Barcelona, Spain. In Curr Cancer Drug Targets, 2013
Deubiquitinating enzymes (or DUBs) attack the ubiquitin-based isopeptide bond, thus counteracting ubiquitinprotein ligase activity in vivo.
Molecular mechanisms and functions of cytokine-inducible deubiquitinating enzymes.
Baek et al., South Korea. In Cytokine Growth Factor Rev, 2013
Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1, DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes.
Integrating genetic association, genetics of gene expression, and single nucleotide polymorphism set analysis to identify susceptibility Loci for type 2 diabetes mellitus.
Hu et al., Boston, United States. In Am J Epidemiol, 2012
The most significantly associated SNPs to type 2 diabetes mellitus in this study are expression SNPs to the lymphocyte antigen 75 gene, the ubiquitin-specific peptidase 36 gene, and the phosphatidylinositol transfer protein, cytoplasmic 1 gene.
The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins.
Fauvarque et al., Grenoble, France. In Autophagy, 2012
USP36 controls selective autophagy activation in Drosophila and in human cells.
Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36.
Baek et al., Seoul, South Korea. In J Cell Biochem, 2011
Study identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2.
Nucleophosmin/B23 regulates ubiquitin dynamics in nucleoli by recruiting deubiquitylating enzyme USP36.
Komada et al., Yokohama, Japan. In J Biol Chem, 2009
Data suggest that nucleophosmin/B23 recruits USP36 to nucleoli, thereby serving as a platform for the regulation of nucleolar protein functions through ubiquitylation/deubiquitylation.
Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.
Komada et al., Yokohama, Japan. In J Cell Sci, 2009
Results suggest that by deubiquitylating various nucleolar substrate proteins including nucleophosmin/B23 and fibrillarin, USP36 plays a crucial role in regulating the structure and function of nucleoli.
DUBA: a deubiquitinase that regulates type I interferon production.
Dixit et al., San Francisco, United States. In Science, 2008
Deubiquitinating enzyme A (DUBA), an ovarian tumor domain-containing deubiquitinating enzyme, was discovered in a small interfering RNA-based screen as a regulator of IFN-I production.
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.
Finley et al., Boston, United States. In Cell, 2006
Ubiquitin chains serve as a recognition motif for the proteasome, a multisubunit protease, which degrades its substrates into polypeptides while releasing ubiquitin for reuse.
Conjugation and deconjugation of ubiquitin regulating the destiny of proteins.
Baek, Seoul, South Korea. In Exp Mol Med, 2003
Mouse deubiquitinating enzymes including DUB-1, DUB-2, and DUB-2A have been isolated and they showed the expression specificity.
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