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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Deltex 2 homolog

DTX2, Deltex2
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] (from NCBI)
Top mentioned proteins: ACID, fibrillin-1, DSP, CAN, STEP
Papers on DTX2
Analysis of diarrhetic shellfish poisoning toxins and pectenotoxin-2 in the bottlenose dolphin (Tursiops truncatus) by liquid chromatography-tandem mass spectrometry.
Ramsdell et al., Charleston, United States. In J Chromatogr A, Nov 2015
Sample preparation and LC-MS/MS methods for the determination of three diarrhetic shellfish poisoning (DSP) toxins (okadaic acid, OA; dinophysistoxin-1, DTX1; dinophysistoxin-2, DTX2) and pectenotoxin-2 (PTX2) in bottlenose dolphin (Tursiops truncatus) urine and tissue samples were evaluated using spike-and-recovery tests.
Development and Validation of a Lateral Flow Immunoassay for the Rapid Screening of Okadaic Acid and All Dinophysis Toxins from Shellfish Extracts.
Elliott et al., Lansing, United States. In J Agric Food Chem, Oct 2015
Sample homogenates could be screened in 20 min (including extraction and assay time) for the presence of free toxins (OA, DTX1, DTX2).
Occurrence of lipophilic marine toxins in shellfish from Galicia (NW of Spain) and synergies among them.
Cabado et al., Vigo, Spain. In Mar Drugs, Apr 2015
Results show that combination of OA with dinophysistoxin 2 (DTX2) or YTX enhances the toxicity triggered by OA, decreasing cell viability and cell proliferation, depending on the toxin concentration and incubation time.
Lipophilic toxins in cultivated mussels (Mytilus galloprovincialis) from Baja California, Mexico.
Peña-Manjarrez et al., Ensenada, Mexico. In Toxicon, 2014
The concentration of okadaic acid (OA), dinophysistoxin 2 (DTX2), and pectenotoxin 2 (PTX2) reached 500 μg kg(-1) during July and increased to 1647 μg kg(-1) in October.
Intralaboratory validation of a fast and sensitive UHPLC/MS/MS method with fast polarity switching for the analysis of lipophilic shellfish toxins.
Gago-Martínez et al., In J Aoac Int, 2014
For accurate quantification matrix-matched calibrations were used when analyzing reference mussel materials, providing recoveries for OA, Dynophysis toxins (DTX)1, DTX2, YTX, AZA1, and SPX1 between 80 and 120% with RSDs below 8% over a 3-day validation procedure.
Experimental basis for the high oral toxicity of dinophysistoxin 1: a comparative study of DSP.
Botana et al., Lugo, Spain. In Toxins (basel), 2014
Okadaic acid (OA) and its analogues, dinophysistoxin 1 (DTX1) and dinophysistoxin 2 (DTX2), are lipophilic and heat-stable marine toxins produced by dinoflagellates, which can accumulate in filter-feeding bivalves.
[Can solar/geomagnetic activity restrict the occurrence of some shellfish poisoning outbreaks? The example of PSP caused by Gymnodinium catenatum at the Atlantic Portuguese coast].
Vale, In Biofizika, 2013
A comparison between monthly distribution of PSP and other common biotoxins (okadaic acid (OA), dinophysistoxin-2 (DTX2) and amnesic shellfish poisoning (ASP) toxins) demonstrated that only PSP was significantly associated with low levels of radio flux (p < 0.01).
Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.
Cascinu et al., Ancona, Italy. In Plos One, 2012
Among of all genes tested, those with the higher "weight" in determining different prognosis were CD44, ALCAM, DTX2, HSPA9, CCNA2, PDX1, MYST1, COL1A1 and ABCG2.
Elucidation of the mass fragmentation pathways of the polyether marine toxins, dinophysistoxins, and identification of isomer discrimination processes.
James et al., Cork, Ireland. In Rapid Commun Mass Spectrom, 2012
RATIONALE: Most of the liquid chromatography/mass spectrometry (LC/MS) methods that have been developed for the analysis of Diarrhetic Shellfish Poisoning (DSP) toxins in shellfish and algae samples have been unable to differentiate the isomers okadaic acid (OA) and dinophysistoxin-2 (DTX2), unless separated by chromatography.
Acute myeloid leukemia with t(7;21)(q11.2;q22) expresses a novel, reversed-sequence RUNX1-DTX2 chimera.
Mitani et al., Mibu, Japan. In Int J Hematol, 2012
3'-rapid amplification of cDNA ends analysis showed a tail-to-tail fusion between RUNX1 on 21q22 and DTX2 on 7q11.2, with an insertion of short complementary sequence from UPK3B adjacent to DTX2.
Identification strategy using combined mass spectrometric techniques for elucidation of phase I and phase II in vitro metabolites of lipophilic marine biotoxins.
These et al., Berlin, Germany. In Anal Chem, 2010
Combining mass spectrometric tools, a total of 47 in vitro metabolites of okadaic acid (OA), dinophysistoxins 1 and 2 (DTX1 and DTX2), yessotoxin (YTX), azaspiracid1 (AZA1), and pectenotoxin 2 (PTX2) could be detected and confirmed after an incubation with rat liver S9-mix.
Naturally contaminated shellfish samples: quantification of diarrhetic shellfish poisoning toxins in unhydrolysed and hydrolysed extracts and cytotoxicity assessment.
Oliveira et al., Lisbon, Portugal. In J Appl Toxicol, 2010
Contamination of shellfish from the Portuguese coast with diarrhetic shellfish poisoning (DSP) toxins is a recurrent event, with most of the commercial bivalves contaminated with high percentages of esters of okadaic acid (OA) and dinophysistoxin-2 (DTX2).
Temperature and base requirements for the alkaline hydrolysis of okadaite's esters.
Vale et al., Lisbon, Portugal. In Toxicon, 2009
Portuguese bivalves are recurrently contaminated with okadaic acid (OA) and dinophysistoxin-2 (DTX2), found mainly in esterified forms.
First detection of Pectenotoxin-11 and confirmation of OA-D8 diol-ester in Dinophysis acuta from European waters by LC-MS/MS.
Reguera et al., Vigo, Spain. In Toxicon, 2009
OA-D8 diol-ester and PTX11 were detected in co-occurrence with okadaic acid analogues (OA, DTX2) and PTX2 in plankton concentrates dominated by D. acuta.
Detection of diarrheic shellfish poisoning and azaspiracid toxins in Moroccan mussels: comparison of the LC-MS method with the commercial immunoassay kit.
Fassouane et al., El Jadida, Morocco. In Mar Drugs, 2007
The LC-MS method was found to be able to detect a high level of okadaic acid (OA), low level of dinophysistoxin-2 (DTX2), and surprisingly, traces of azaspiracids 2 (AZA2) in mussels.
T cells develop normally in the absence of both Deltex1 and Deltex2.
Bevan et al., Seattle, United States. In Mol Cell Biol, 2006
Deltex can act as a negative regulator of Notch signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch signals during thymocyte development
cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos.
Wu et al., Shanghai, China. In Dna Seq, 2006
DTX2 is a gene encoding a WWE-RING-finger protein and involved in regulating heart development and heart functions.
The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.
Shipp et al., Boston, United States. In J Biol Chem, 2003
It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination.
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