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Dystrobrevin binding protein 1

DTNBP1, Dysbindin, dystrobrevin binding protein 1
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DISC1, Catechol O-Methyltransferase, RGS4, CAN, iMpact
Papers using DTNBP1 antibodies
Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes.
Keen James, In PLoS ONE, 2008
... For knockdown of endogenous Dysbindin, the following siRNA duplexes were obtained from Qiagen: Dysbindin, DTNBP1 siRNA#1 (Hs_DNTBP1_3), ...
Papers on DTNBP1
Dysbindin-1 modifies signaling and cellular localization of recombinant, human D3 and D2 receptors.
Mannoury la Cour et al., France. In J Neurochem, Jan 2016
UNASSIGNED: Dystrobrevin binding protein-1 (dysbindin-1), a candidate gene for schizophrenia, modulates cognition, synaptic plasticity and frontocortical circuitry and interacts with glutamatergic and dopaminergic transmission.
Antipsychotic drugs attenuate aberrant DNA methylation of DTNBP1 (dysbindin) promoter in saliva and post-mortem brain of patients with schizophrenia and Psychotic bipolar disorder.
Thiagalingam et al., Tehrān, Iran. In Am J Med Genet B Neuropsychiatr Genet, Dec 2015
Here, we report the examination of DNA methylation status of DTNBP1 promoter region, one of the most credible candidate genes affected in SCZ, assayed in saliva and post-mortem brain samples.
Recognition deficits in mice carrying mutations of genes encoding BLOC-1 subunits pallidin or dysbindin.
Karlsgodt et al., Hempstead, United States. In Genes Brain Behav, Nov 2015
Numerous studies have implicated DTNBP1, the gene encoding dystrobrevin-binding protein or dysbindin, as a candidate risk gene for schizophrenia, though this relationship remains somewhat controversial.
Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor.
Faundez et al., Atlanta, United States. In Hum Mol Genet, Nov 2015
Here we focus on the schizophrenia susceptibility gene DTNBP1 and its product dysbindin, a subunit of the BLOC-1 complex, and describe a neuronal pathway modulating copper metabolism via ATP7A.
Regulation of Brain-Derived Neurotrophic Factor Exocytosis and Gamma-Aminobutyric Acidergic Interneuron Synapse by the Schizophrenia Susceptibility Gene Dysbindin-1.
Je et al., Singapore, Singapore. In Biol Psychiatry, Sep 2015
BACKGROUND: Genetic variations in dystrobrevin binding protein 1 (DTNBP1 or dysbindin-1) have been implicated as risk factors in the pathogenesis of schizophrenia.
Hierarchical Classes Analysis (HICLAS): A novel data reduction method to examine associations between biallelic SNPs and perceptual organization phenotypes in schizophrenia.
Silverstein et al., United States. In Schizophr Res Cogn, Jul 2015
Then, to reduce the total number of candidate SNPs analyzed in association with perceptual organization phenotypes, we employed a two-stage strategy: first a priori SNPs from three candidate genes were selected (GAD1, NRG1 and DTNBP1); then a Hierarchical Classes Analysis (HICLAS) was performed to reduce the total number of SNPs, based on statistically related SNP clusters.
Molecular basis of major psychiatric diseases such as schizophrenia and depression.
Matsuzaki et al., Ōsaka, Japan. In Anat Sci Int, Jun 2015
Recently several potential susceptibility genes for major psychiatric disorders (schizophrenia and major depression) such as disrupted-in-schizophrenia 1(DISC1), dysbindin and pituitary adenylate cyclase-activating polypeptide (PACAP) have been reported.
Evaluating historical candidate genes for schizophrenia.
Sullivan et al., Chapel Hill, United States. In Mol Psychiatry, May 2015
In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1).
Genetic association of single nucleotide polymorphisms in dystrobrevin binding protein 1 gene with schizophrenia in a Malaysian population.
Tang et al., Kuala Lumpur, Malaysia. In Genet Mol Biol, May 2015
Dystrobrevin binding protein 1 (DTNBP1) gene is pivotal in regulating the glutamatergic system.
The Schizophrenia-Related Protein Dysbindin-1A Is Degraded and Facilitates NF-Kappa B Activity in the Nucleus.
Wang et al., Hefei, China. In Plos One, 2014
Dystrobrevin-binding protein 1 (DTNBP1), a gene encoding dysbindin-1, has been identified as a susceptibility gene for schizophrenia.
Dopaminergic function in relation to genes associated with risk for schizophrenia: translational mutant mouse models.
Waddington et al., Cork, Ireland. In Prog Brain Res, 2013
It considers models for understanding the role(s) of risk genes, with a particular focus on DTNBP1 and NRG1, their interactions with environmental factors, and with each other (epistasis).
Clinical and molecular genetics of psychotic depression.
Domschke, Würzburg, Germany. In Schizophr Bull, 2013
Molecular genetic studies point to potential risk loci of psychotic depression shared with schizoaffective disorder (1q42, 22q11, 19p13), depression, bipolar disorder, and schizophrenia (6p, 8p22, 10p13-12, 10p14, 13q13-14, 13q32, 18p, 22q11-13) and several vulnerability genes possibly contributing to an increased risk of psychotic symptoms in depression (eg, BDNF, DBH, DTNBP1, DRD2, DRD4, GSK-3beta, MAO-A).
Evidence for single nucleotide polymorphisms and their association with bipolar disorder.
Szczepankiewicz, Poznań, Poland. In Neuropsychiatr Dis Treat, 2012
The review of association data reveals evidence for several genes (SLC6A4/5-HTT [serotonin transporter gene], BDNF [brain-derived neurotrophic factor], DAOA [D-amino acid oxidase activator], DTNBP1 [dysbindin], NRG1 [neuregulin 1], DISC1 [disrupted in schizophrenia 1]) to be crucial candidates in BD, whereas numerous genome-wide association studies conducted in BD indicate polymorphisms in two genes (CACNA1C [calcium channel, voltage-dependent, L type, alpha 1C subunit], ANK3 [ankyrin 3]) replicated for association with BD in most of these studies.
Upregulation of dysbindin in temporal lobe epileptic foci of human and experimental animals.
Wang et al., Chongqing, China. In Synapse, 2012
The increased expression of dysbindin might play a role in the pathogenesis of drug-refractory temporal lobe epilepsy.
The impact of a Dysbindin schizophrenia susceptibility variant on fiber tract integrity in healthy individuals: a TBSS-based diffusion tensor imaging study.
Kircher et al., Aachen, Germany. In Neuroimage, 2012
Dysbindin has been implicated in neurite outgrowth and morphology. Impairments in anatomic connectivity as found associated with the minor Dysbindin allele in our study may result in increased risk for schizophrenia due to altered fiber tracts
Effects of DTNBP1 genotype on brain development in children.
Mechelli et al., London, United Kingdom. In J Child Psychol Psychiatry, 2011
Our results suggest that genetic variation in DTNBP1 is associated with differences in gray and white matter; and that these effects are already evident in children as young as 10-12 years.
The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.
Faundez et al., Atlanta, United States. In Mol Biol Cell, 2011
dysbindin and its associated complex sort cargoes from cell bodies to the synapse.
Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia.
Siegel et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2011
Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia.
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Bertram et al., United States. In Nat Genet, 2008
Across 118 meta-analyses, a total of 24 genetic variants in 16 different genes (APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally significant effects with average summary odds ratios of approximately 1.23.
Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
Swank et al., Buffalo, United States. In Nat Genet, 2003
sdy mutant mouse expresses no dysbindin protein owing to a deletion in the gene Dtnbp1 (encoding dysbindin) and that mutation of the human ortholog DTNBP1 causes Hermansky-Pudlak syndrome type 7
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