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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ubiquilin 1

Dsk2, ubiquilin, ubiquilin 1, UBQLN1
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, Als, CAN, TDP-43, Presenilin-1
Papers on Dsk2
Ubiquilin Mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.
Hedstrom et al., United States. In J Biol Chem, Feb 2016
Cbz-B3A does not appear to bind directly to mTORC1, but instead binds to ubiquilins 1, 2, and 4. Knockdown of ubiquilin 2, but not ubiquilins 1 and 4, decreases the phosphorylation of 4EBP1, suggesting that ubiquilin 2 activates mTORC1.
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
Hiltunen et al., Kuopio, Finland. In Neurobiol Dis, Jan 2016
Ubiquilin-1, a ubiquitin-like protein, genetically associates with AD and affects APP trafficking, processing and degradation.
Rpn10 monoubiquitination orchestrates the association of the ubiquilin-type DSK2 receptor with the proteasome.
Crosas et al., Barcelona, Spain. In Biochem J, Jan 2016
Despite the progress made in understanding the roles of proteasome polyubiquitin receptors, such as the subunits Rpn10 (regulatory particle non-ATPase 10) and Rpn13, and the transient interactors Rad23 (radiation sensitivity abnormal 23) and Dsk2 (dual-specificity protein kinase 2), the mechanisms involved in their regulation are virtually unknown.
Epstein-Barr virus-encoded LMP1 increases miR-155 expression, which promotes radioresistance of nasopharyngeal carcinoma via suppressing UBQLN1.
Hu et al., Daqing, China. In Eur Rev Med Pharmacol Sci, Dec 2015
MATERIALS AND METHODS: MiR-155, LMP1 and ubiquilin-1 expression were measured in 40 cases of NPC cases.
The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation.
Anrather et al., New York City, United States. In Nucleic Acids Res, Dec 2015
Rather, we show that HERC3 and RelA are part of a multi-protein complex containing the proteasome as well as the ubiquitin-like protein ubiquilin-1 (UBQLN1).
Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neurologic Disease.
Lupski et al., Houston, United States. In Neuron, Dec 2015
Among the candidate genes identified, we found PRUNE, VARS, and DHX37 in multiple families and homozygous loss-of-function variants in AGBL2, SLC18A2, SMARCA1, UBQLN1, and CPLX1.
Endoplasmic reticulum stress and proteasomal system in amyotrophic lateral sclerosis.
Ozer et al., İstanbul, Turkey. In Free Radic Biol Med, Nov 2015
Mutation of many different genes are involved in the pathogenesis such as superoxide dismutase 1, chromosome 9 open reading frame 72 and ubiquilin 2. These genes are mainly related to the antioxidant defense systems, endoplasmic reticulum stress related proteins and also protein aggregation, degradation pathways and therefore mutation of these genes cause related disorders.This review focused on the role of protein processing via endoplasmic reticulum and proteasomal system in amyotrophic lateral sclerosis which are the main players in the pathology.
Autophagy receptor defects and ALS-FTLD.
Layfield et al., Nottingham, United Kingdom. In Mol Cell Neurosci, May 2015
Growing evidence suggests that the autophagic process can be disturbed in ALS-FTLD, including by genetic mutations affecting autophagy receptor proteins (ubiquilin-2, optineurin, SQSTM1/p62) and regulators (VCP).
Prognostic significance of Ubiquilin1 expression in invasive breast cancer.
Li et al., Beijing, China. In Cancer Biomark, 2014
AIM: To explore the correlation between Ubiquilin1 (UBQLN1) expression and clinicopathological characteristics and determine its prognostic significance in patients with breast cancer.
Inhibitory effect of chloroquine derivatives on presenilin 1 and ubiquilin 1 expression in Alzheimer's disease.
Li et al., Xinxiang, China. In Int J Clin Exp Pathol, 2014
It was observed that chloroquine derivative D5 downregulates presenilin expression via the inhibition of ubiquilin 1 expression.
[Possibility of the natural product extracted from Calophyllum Brasiliense].
Kimura, In Nihon Rinsho, 2014
GUT-70 and BNS-22 commonly inhibited ubiquilin-1, suggesting that a GUT-70 derivative might become a First in Class agent.
Ubiquilin 2: a component of the ubiquitin-proteasome system with an emerging role in neurodegeneration.
Blair et al., Sydney, Australia. In Int J Biochem Cell Biol, 2014
Ubiquilin 2, which is encoded by the UBQLN2 gene, plays a critical role in protein clearance pathways including the ubiquitin-proteasome system and autophagy.
Relationship between amyloid-beta and the ubiquitin-proteasome system in Alzheimer's disease.
Jiang et al., In Neurol Res, 2014
Mutant ubiquitin (Ub) and ubiquitin-like (UBL) ubiquilin-1 are related to Abeta accumulation.
Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.
Boehning et al., Galveston, United States. In Proc Natl Acad Sci U S A, 2012
These results reveal the mechanistic basis by which ubiquilin-1 regulates APP maturation.
Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.
Trojanowski et al., Philadelphia, United States. In Acta Neuropathol, 2012
Found a pathophysiological link between C9ORF72 expansions and ubiquilin-2 (UBQLN) proteins in amyotrophic lateral sclerosis and frontotemporal lobar degeneration that is associated with a highly characteristic pattern of UBQLN pathology.
UBQ-8i polymorphism is not an independent risk factor for mild cognitive impairment and Alzheimer's disease in APOE-4 carriers.
Pancorbo et al., Vitoria-Gasteiz, Spain. In Curr Alzheimer Res, 2012
This study demonistrated that Allele C of polymorphism UBQ-8i of the UBQLN1 gene is not an independent risk factor for mild cognitive impairment or Alzheimer's disease
Mutations in UBQLN2 are rare in French amyotrophic lateral sclerosis.
Salachas et al., Paris, France. In Neurobiol Aging, 2012
The results of this study suggested that UBQLN2 gene mutations are rare in French amyotrophic lateral sclerosis.
Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.
Varmus et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
Ubqln stabilizes BCLb protein, while also promoting monoubiquitination on multiple lysine residues and relocation to the cytosol.
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Siddique et al., Chicago, United States. In Nature, 2011
findings link abnormalities in ubiquilin 2 to defects in the protein degradation pathway, abnormal protein aggregation and neurodegeneration, indicating a common pathogenic mechanism that can be exploited for therapeutic intervention
Family-based association between Alzheimer's disease and variants in UBQLN1.
Tanzi et al., United States. In N Engl J Med, 2005
Our findings suggest that genetic variants in UBQLN1 on chromosome 9q22 substantially increase the risk of Alzheimer's disease, possibly by influencing alternative splicing of this gene in the brain
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