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Dermatan sulfate epimerase

The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, CB1
Papers on DSE
Functional and transcript analysis of a novel metal transporter gene EpNramp from a dark septate endophyte (Exophiala pisciphila).
Zhao et al., Kunming, China. In Ecotoxicol Environ Saf, Feb 2016
In the current study, a ubiquitous and evolutionary conserved metal transporter gene, homology to natural resistance associated macrophage protein (Nramp), was cloned from a metal-tolerant isolate of dark septate endophyte (DSE, Exophiala pisciphila), and its functional and transcript characterization were analyzed.
Developing high throughput quantitative PCR assays for diagnosing Ikeda and other Theileria orientalis types common to New Zealand in bovine blood samples.
McFadden et al., Upper Hutt, New Zealand. In N Z Vet J, Jan 2016
Diagnostic specificity (DSp) and sensitivity (DSe) estimates for the qPCR assays were compared to blood smear piroplasm results, and other PCR assays for T. orientalis.
Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein (GCKR) Inhibition: GCKR-Leu446Pro Variant in Look AHEAD.
Genetics Subgroup of the Look AHEAD Study et al., Boston, United States. In Circ Cardiovasc Genet, Dec 2015
METHODS AND RESULTS: -We investigated whether a 1-year intensive lifestyle intervention for weight loss (ILI) would avert the unfavorable cardiometabolic effects associated with GCKR Leu446Pro when compared to a diabetes support and education arm (DSE) in overweight/obese individuals with type 2 diabetes with triglyceride (n=3,214) and CRP (n=1,411) data participating in a randomized lifestyle intervention study for weight loss, Look AHEAD (Action for Health in Diabetes).
CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding PAPα.
Laishram et al., Thiruvananthapuram, India. In Nucleic Acids Res, Nov 2015
We identified a Star-PAP recognition nucleotide motif and showed that suboptimal DSE on Star-PAP target pre-mRNA 3'-UTRs inhibit CstF-64 binding, thus preventing PAPα recruitment onto it.
EntropyExplorer: an R package for computing and comparing differential Shannon entropy, differential coefficient of variation and differential expression.
Langston et al., Knoxville, United States. In Bmc Res Notes, 2014
BACKGROUND: Differential Shannon entropy (DSE) and differential coefficient of variation (DCV) are effective metrics for the study of gene expression data.
The herbaceous landlord: integrating the effects of symbiont consortia within a single host.
Bridgham et al., Eugene, United States. In Peerj, 2014
Plants are typically infected by a consortium of internal fungal associates, including endophytes in their leaves, as well as arbuscular mycorrhizal fungi (AMF) and dark septate endophytes (DSE) in their roots.
Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review.
Veillette et al., Toronto, Canada. In Arthritis, 2012
The genes reviewed are for small leucine-rich proteoglycans (lumican, fibromodulin, biglycan, decorin, and asporin); dermatan sulfate epimerase (Dse) that alters structure of glycosaminoglycan and hence the function of small leucine-rich proteoglycans by converting glucuronic to iduronic acid; matricellular proteins (thrombospondin 2, secreted phosphoprotein 1 (Spp1), secreted protein acidic and rich in cysteine (Sparc), periostin, and tenascin X) including human tenascin C variants; and others, such as tenomodulin, leukocyte cell derived chemotaxin 1 (chondromodulin-I, ChM-I), CD44 antigen (Cd44), lubricin (Prg4), and aggrecan degrading gene, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (Adamts5).
Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma.
Malmström et al., Lund, Sweden. In Cancer Res, 2012
Dermatan sulfate epimerase 1 was highly upregulated in esophagus squamous cell carcinoma
Residual structure in unfolded proteins.
Bowler, Missoula, United States. In Curr Opin Struct Biol, 2012
The denatured state ensemble (DSE) of unfolded proteins, once considered to be well-modeled by an energetically featureless random coil, is now well-known to contain flickering elements of residual structure.
A Fourier transform method for powder diffraction based on the Debye scattering equation.
Thomas, Koblenz, Germany. In Acta Crystallogr A, 2011
A fast Fourier transform algorithm is introduced into the method recently defined for calculating powder diffraction patterns by means of the Debye scattering equation (DSE) [Thomas (2010).
Dermatan sulfate epimerase 1-deficient mice have reduced content and changed distribution of iduronic acids in dermatan sulfate and an altered collagen structure in skin.
Malmström et al., Lund, Sweden. In Mol Cell Biol, 2009
DS-epi1-deficient mice show chondroitin sulfate /dermatan sulfate with a marked deficiency in iduronic acid-containing structures.
Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function.
Malmström et al., Lund, Sweden. In J Biol Chem, 2009
Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function.
[Progress on cis-acting regulatory elements in nonsense-mediated mRNA decay].
Guo et al., Guangzhou, China. In Yi Chuan Xue Bao, 2004
They are PTC presence, PTC recongnation by downstream elements that termed as downstream sequence element (DSE) in yeast and primarily exon-exon junction ( EEJ) in mammalian cells, stabilizer sequence (STE) inactivation the NMD, and other sequences correlated with NMD such as extended poly (A) in 3' UTRs,upstream open reading frame (uORF) located in 5' UTR and programmed -1 ribosomal frameshift (-1 PRF).
Endocannabinoid-mediated short-term synaptic plasticity: depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE).
Marty et al., Paris, France. In Br J Pharmacol, 2004
Depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE) are two related forms of short-term synaptic plasticity of GABAergic and glutamatergic transmission, respectively.
Cannabinoid physiology and pharmacology: 30 years of progress.
Porrino et al., Durham, United States. In Neuropharmacology, 2003
Post-synaptically generated endocannabinoids form the basis of a retrograde signaling mechanism referred to as depolarization-induced suppression of inhibition (DSI) or excitation (DSE).
The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter.
Nordheim et al., Heidelberg, Germany. In Cell, 1989
The SRE contains a 20 bp element of interrupted dyad symmetry (DSE) that is bound by p67/SRF.
A common octamer motif binding protein is involved in the transcription of U6 snRNA by RNA polymerase III and U2 snRNA by RNA polymerase II.
Mattaj et al., Strasbourg, France. In Cell, 1987
These regions contain not only functional but also sequence homology to the previously defined distal and proximal sequence elements (DSE and PSE) of the Xenopus U2 promoter, although U2 is transcribed by RNA polymerase II and U6 by RNA polymerase III.
A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes.
Mattaj et al., In Nature, 1987
We analysed such a site of protein-DNA interaction, the octamer motif, in the enhancers of the simian virus (SV40) early genes and the murine immunoglobulin heavy-chain gene, and in the distal sequence element (DSE) of the U2 small nuclear (sn)RNA gene of Xenopus laevis.
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