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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Drebrin 1

Drebrin, drebrin A, drebrin E
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, CAN, V1a, ACID, PSD-95
Papers on Drebrin
Drebrin Coordinates the Actin and Microtubule Cytoskeleton During the Initiation of Axon Collateral Branches.
Gallo et al., Plymouth, United Kingdom. In Dev Neurobiol, Feb 2016
UNASSIGNED: Drebrin is a cytoskeleton-associated protein which can interact with both actin filaments and the tips of microtubules.
Drebrin and cognitive impairment.
Wang et al., Beijing, China. In Clin Chim Acta, Jan 2016
Drebrin is a neuron growth and brain development-related actin-binding protein and is present in 70% of the dendritic spines of excitatory synapses.
Allopregnanolone increases mature excitatory synapses along dendrites via protein kinase A signaling.
Shirao et al., Maebashi, Japan. In Neuroscience, Nov 2015
Drebrin, which is an actin-binding protein, forms a unique stable actin structure in dendritic spines, and drebrin levels correlate positively with cognitive levels in AD and mild cognitive impairment.
Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses.
August et al., Ithaca, United States. In J Immunol, Aug 2015
We have previously identified the actin reorganizing protein Drebrin as a target of the immunosuppressant 3,5-bistrifluoromethyl pyrazole, which inhibits calcium influx into cells.
Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus.
Lubec et al., Vienna, Austria. In J Neurochem, Jul 2015
Drebrin an actin-bundling key regulator of dendritic spine genesis and morphology, has been recently proposed as a regulator of hippocampal glutamatergic activity which is critical for memory formation and maintenance.
Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction.
Klopfenstein et al., Göttingen, Germany. In Nat Commun, 2014
Here we identify and functionally characterize a Caenorhabditis elegans drebrin-like protein DBN-1 as a novel constituent of the muscle contraction machinery.
Drebrin regulates neuroblast migration in the postnatal mammalian brain.
Lalli et al., London, United Kingdom. In Plos One, 2014
Here, we have investigated the function of drebrin, an actin-binding protein highly expressed in the RMS of the postnatal mammalian brain.
Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo.
Yoshida et al., Tokyo, Japan. In Plos One, 2014
The level of drebrin, an evolutionarily conserved f-actin-binding protein that regulates synaptic structure and function, is reduced in the brains of patients with chronic neurodegenerative diseases such as Alzheimer's disease (AD) and Down's syndrome (DS).
Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid beta oligomers.
Shirao et al., Maebashi, Japan. In Neurochem Int, 2014
Drebrin is an actin-binding protein that is located at mature dendritic spines.
Drebrin inhibits cofilin-induced severing of F-actin.
Reisler et al., Los Angeles, United States. In Cytoskeleton (hoboken), 2014
Molecular cross-talk between neuronal drebrin A and cofilin is believed to be a part of the activity-dependent cytoskeleton-modulating pathway in dendritic spines.
Proteomic analysis of Nipponia nippon (ID#162).
Mitsui et al., Niigata, Japan. In Anim Sci J, 2014
It has been reported that drebrin A is specifically expressed in adult chicken brain.
Drebrin A expression is altered after pilocarpine-induced seizures: time course of changes is consistent for a role in the integrity and stability of dendritic spines of hippocampal granule cells.
Ferhat et al., Marseille, France. In Hippocampus, 2012
our results indicate that in vivo drebrin A is not critical for spinogenesis and morphogenesis but instead is consistent with an involvement in synaptic structural integrity, stabilization, and function.
Hippocampal drebrin loss in mild cognitive impairment.
Mufson et al., Chicago, United States. In Neurodegener Dis, 2011
The results of this study showed that Hippocampal drebrin loss in mild cognitive impairment.
High expression of cytoskeletal protein drebrin in TEL/AML1pos B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody.
Hrusak et al., Praha, Czech Republic. In Leuk Res, 2011
High expression of cytoskeletal protein drebrin is associated with TEL/AML1pos B-cell precursor acute lymphoblastic leukemia
Low accumulation of drebrin at glutamatergic postsynaptic sites on GABAergic neurons.
Shirao et al., Maebashi, Japan. In Neuroscience, 2010
The density of drebrin-positive glutamatergic synapses formed on GABAergic neurons is lower than those on glutamatergic neurons.
Control of cell shape and plasticity during development and disease by the actin-binding protein Drebrin.
Chilton et al., Plymouth, United Kingdom. In Histol Histopathol, 2010
The downregulation of Drebrin in Alzheimer's Disease and Down Syndrome and conversely its upregulation in various carcinomas indicate that Drebrin is an important component of the pathogenesis of multiple diseases.
Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma.
Sander et al., Huddinge, Sweden. In Plos One, 2009
Data show that DBN1, SETMAR and HIG2 are direct transcriptional targets of the SOX11 protein.
Role of actin cytoskeleton in dendritic spine morphogenesis.
Shirao et al., Maebashi, Japan. In Neurochem Int, 2007
Drebrin, a spine-resident side-binding protein of filamentous actin (F-actin), is responsible for recruiting F-actin and PSD-95 into filopodia, and is suggested to govern spine morphogenesis.
Many faces of drebrin: from building dendritic spines and stabilizing gap junctions to shaping neurite-like cell processes.
Duden et al., London, United Kingdom. In Histochem Cell Biol, 2007
In this review we consider the multiple functions of developmentally regulated brain protein (drebrin), an actin-binding protein, in the formation of cellular polarity in different cell types.
[Synaptic development and abnormality at protein level].
Takahashi et al., Maebashi, Japan. In Nihon Shinkei Seishin Yakurigaku Zasshi, 2004
Since the drebrin-A isoform is necessary for the cluster formation, the regulation of drebrin A expression is now a focus in the field of spine formation.
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