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Dopamine receptor D2

DRD2, dopamine D2 receptor, D2R
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, AGE, ANKK1
Papers using DRD2 antibodies
Adenosine A2a receptor mRNA is expressed by enkephalin cells but not by somatostatin cells in rat striatum: a co-expression study.
Mansvelder Huibert D., In PLoS ONE, 1993
... drd2-EGFP double transgenic mice, each from a different ...
Dopaminergic modulation of cholinergic responses in rat medial prefrontal cortex: an electrophysiological study
Vaucher Elvire et al., In Frontiers in Neuroanatomy, 1989
... Drd2-EGFP double transgenic mice (Gong et al., ...
Papers on DRD2
Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.
Ferré, Baltimore, United States. In Psychopharmacology (berl), Feb 2016
OBJECTIVES: A model that considers the striatal adenosine A2A-dopamine D2 receptor heteromer as a key modulator of dopamine-dependent striatal functions (reward-oriented behavior and learning of stimulus-reward and reward-response associations) is introduced, which should explain most of the psychomotor and reinforcing effects of caffeine.
p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism.
Svenningsson et al., Stockholm, Sweden. In Proc Natl Acad Sci U S A, Feb 2016
Mice lacking p11 in dopamine D2R-containing neurons have a reduced response to L-DOPA on the therapeutic parameters, but develop dyskinetic side effects.
Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala.
Valjent et al., Montpellier, France. In Mol Psychiatry, Feb 2016
Here we report that the modulation of DA D2 receptor (D2R) signaling bidirectionally regulates the consolidation of fear responses.
Dopamine D2 receptors are involved in the regulation of fyn and metabotropic glutamate receptor 5 phosphorylation in the rat striatum in vivo.
Wang et al., Kansas City, United States. In J Neurosci Res, Feb 2016
This study characterizes the D2R-dependent regulation of Fyn in the rat striatum in vivo.
Prenatal immune activation in mice blocks the effects of environmental enrichment on exploratory behavior and microglia density.
Ambrée et al., Münster, Germany. In Prog Neuropsychopharmacol Biol Psychiatry, Feb 2016
Prenatal polyI:C treatment resulted in increased dopamine sensitivity and dopamine D2 receptor expression in adult offspring which was not reversed by environmental enrichment.
Dopaminergic drugs in type 2 diabetes and glucose homeostasis.
Becu-Villalobos et al., Buenos Aires, Argentina. In Pharmacol Res, Jan 2016
Mutant mice lacking dopamine type 2 receptors (D2R) are glucose intolerant and have abnormal insulin secretion.
Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.
Matthys et al., Amsterdam, Netherlands. In Clin Child Fam Psychol Rev, Dec 2015
Over the last decade, several candidate genes (i.e., MAOA, DRD4, DRD2, DAT1, 5-HTTLPR, and COMT) have been extensively studied as potential moderators of the detrimental effects of postnatal family adversity on child externalizing behaviors, such as aggression and conduct disorder.
Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders.
Paspalas et al., New Haven, United States. In Pharmacol Rev, Jul 2015
DA has differing effects via D1 (D1R) versus D2 receptor (D2R) families.
Dopamine and Somatostatin Analogues Resistance of Pituitary Tumors: Focus on Cytoskeleton Involvement.
Mantovani et al., Milano, Italy. In Front Endocrinol (lausanne), 2014
Dopamine (DA) receptor DRD2 and somatostatin (SS) receptors (SSTRs) represent the main targets of pharmacological treatment of pituitary tumors since they mediate inhibitory effects on both hormone secretion and cell proliferation, and their expression is retained by most of these tumors.
Alterations of Dopamine D2 Receptors and Related Receptor-Interacting Proteins in Schizophrenia: The Pivotal Position of Dopamine Supersensitivity Psychosis in Treatment-Resistant Schizophrenia.
Iyo et al., Chiba, Japan. In Int J Mol Sci, 2014
Although the dopamine D2 receptor (DRD2) has been a main target of antipsychotic pharmacotherapy for the treatment of schizophrenia, the standard treatment does not offer sufficient relief of symptoms to 20%-30% of patients suffering from this disorder.
Relationship Between L-DOPA-Induced Reduction in Motor and Exploratory Activity and Striatal Dopamine D2 Receptor Binding in the Rat.
Müller et al., Düsseldorf, Germany. In Front Behav Neurosci, 2014
PURPOSE: The present study assessed the influence of L-DOPA administration on neostriatal dopamine (DA) D2 receptor binding in relation to motor and exploratory behaviors in the rat.
Biological insights from 108 schizophrenia-associated genetic loci.
Schizophrenia Working Group of the Psychiatric Genomics Consortium, In Nature, 2014
Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin.
Zhou et al., Shanghai, China. In Nature, 2013
Here we show that the astrocytic dopamine D2 receptor (DRD2) modulates innate immunity through αB-crystallin (CRYAB), which is known to suppress neuroinflammation.
DRD2/ANKK1 TaqI A genotype moderates the relationship between alexithymia and the relative value of alcohol among male college binge drinkers.
Mackillop et al., Lincoln, United States. In Pharmacol Biochem Behav, 2012
The A1 allele of DRD2/ANKK1 TaqI A interacts with hypoemotionality to predict a novel index of problem drinking
Pharmacogenomic associations with weight gain in olanzapine treatment of patients without schizophrenia.
Fijal et al., Indianapolis, United States. In J Clin Psychiatry, 2012
The A allele of DRD2 rs2440390(A/G) was associated with greater weight gain in the entire study sample.
A comparison of striatal-dependent behaviors in wild-type and hemizygous Drd1a and Drd2 BAC transgenic mice.
Kreitzer et al., San Francisco, United States. In J Neurosci, 2012
Comparison of behavioral studies in wild-type C57BL/6 mice and hemizygous Drd2 mice backcrossed into C57BL/6 background finds open-field locomotion, conditioned place preference, and avoidance learning are indistinguishable in the transgenic lines.
Striatal dopamine D₂/D₃ receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans.
London et al., Los Angeles, United States. In J Neurosci, 2012
results suggest that striatal D2-like receptor function in humans plays a major role in the neural circuitry that mediates behavioral control.
[Genetic determinants of the alcohol dependence syndrome: searching for an endophenotype associated with sweet liking in families with alcohol addiction].
Jabłoński, Szczecin, Poland. In Ann Acad Med Stetin, 2010
Changes in the distribution of alleles and genotypes of the TaqI DRD2 polymorphism correlated with sucrose preference among alcoholics
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.
Stevens et al., Los Angeles, United States. In Science, 2010
The crystal structure of the human dopamine D3 receptor (D3R) in complex with the small molecule D2R/D3R-specific antagonist eticlopride reveals important features of the ligand binding pocket and extracellular loops.
Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele.
Small et al., Eugene, United States. In Science, 2008
findings imply that individuals may overeat to compensate for a hypofunctioning dorsal striatum, particularly those with dopamine D2 recepttor genetic polymorphisms thought to attenuate dopamine signaling in this region
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