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Major histocompatibility complex, class II, DR beta 1

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HLA-A, HAD, DR4, PrP
Papers using DRB1 antibodies
Using CisGenome to analyze ChIP-chip and ChIP-seq data
Kakutani Tetsuji, In PLoS Genetics, 2010
... DR5pro:GUS [34] transgenic plants are in the ...
Role of PIN-mediated auxin efflux in apical hook development of Arabidopsis thaliana
Sharma Rameshwar et al., In Plant Physiology, 2009
... DR5::GUS transgenic line ( ...
Roles of extensins in cotyledon primordium formation and shoot apical meristem activity in Nicotiana tabacum
Zhao Jie et al., In Journal of Experimental Botany, 2007
... DR5::GUS transgenic plants (kindly provided by ...
Gene expression and primary functional characterization of human DR5 extracellular fragment
Shen Beifen et al., In BMC Immunology, 2006
... antibody was purchased from Sigma-Aldrich; Mouse anti-caspase-8 monoclonal antibody (mAb) was from BD Bioscience; Mouse anti-DR5 monoclonal antibody was from eBioscience; Rabbit anti-FADD mAb was ...
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Papers on DRB1
MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo.
Dinarello et al., Milano, Italy. In Proc Natl Acad Sci U S A, Feb 2016
Here, we fine-map vitiligo MHC class II genetic risk to three SNPs only 47 bp apart, located within a predicted super-enhancer in an intergenic region between HLA-DRB1 and HLA-DQA1, localized by a genome-wide association study of 2,853 Caucasian vitiligo patients.
Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells.
Fulda et al., Frankfurt am Main, Germany. In Oncotarget, Feb 2016
By comparison, A172 cells are significantly protected against IFNα/BV6 treatment by blockage of TRAIL signaling through genetic silencing of TRAIL or its cognate receptor TRAIL receptor 2 (DR5).
HLA-DRB1 alleles of susceptibility and protection in Iranians with autoimmune hepatitis.
Tajik et al., Tehrān, Iran. In Hum Immunol, Feb 2016
The aim of this study was to determine the frequency of HLA-DRB1 alleles in Iranian patients with AIH and investigate the association between HLA alleles and the different types of the disease.
Histophilus somni Surface Proteins.
Corbeil, San Diego, United States. In Curr Top Microbiol Immunol, Feb 2016
Two repeat domains (DR1 and DR2) have cytotoxic Fic motifs.
Hunting down factor VIII in the immunopeptidome.
Voorberg et al., Amsterdam, Netherlands. In Cell Immunol, Dec 2015
In a complementary approach HLA-DRB1(∗)15 transgenic mice were used to identify HLA-DRB1(∗)15 restricted CD4+ T cells reactive towards human FVIII.
Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease.
Pocock et al., London, United Kingdom. In Curr Opin Neurobiol, Nov 2015
The findings strongly implicate genes related to the immune response (CR1, CD33, MS4A, CLU, ABCA7, EPHA1 and HLA-DRB5-HLA-DRB1), endocytosis (BIN1, PICALM, CD2AP, EPHA1 and SORL1) and lipid biology (CLU, ABCA7 and SORL1) [2-8], and many encode proteins which are highly expressed in microglia [1].
High HLA-DP Expression and Graft-versus-Host Disease.
Stevenson et al., Frederick, United States. In N Engl J Med, Sep 2015
Among 1441 recipients of transplants from HLA-A,B,C,DRB1,DQB1-matched unrelated donors with only one HLA-DPB1 mismatch, linkage of the rs9277534 A and G alleles to the mismatched HLA-DPB1 was determined.
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.
Raychaudhuri et al., Boston, United States. In Nat Genet, Aug 2015
The three positions together explained 90% of the phenotypic variance in the HLA-DRB1-HLA-DQA1-HLA-DQB1 locus.
Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese.
Kubo et al., Tokyo, Japan. In Nat Genet, Jul 2015
We applied HLA imputation to genome-wide association study (GWAS) data for Graves' disease in Japanese (n = 9,003) and found that amino acid polymorphisms of multiple class I and class II HLA genes independently contribute to disease risk (HLA-DPB1, HLA-A, HLA-B and HLA-DRB1; P < 2.3 × 10(-6)), with the strongest impact at HLA-DPB1 (P = 1.6 × 10(-42)).
Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.
Barton et al., Manchester, United Kingdom. In Jama, May 2015
OBJECTIVE: To assess whether specific HLA-DRB1 haplotypes associated with rheumatoid arthritis (RA) susceptibility are also associated with radiological severity, mortality, and response to tumor necrosis factor (TNF) inhibitor drugs.
Chimeric DCL1-Partnering Proteins Provide Insights into the MicroRNA Pathway.
Waterhouse et al., Sydney, Australia. In Front Plant Sci, 2014
In Arabidopsis thaliana, efficient microRNA (miRNA) production requires DICER-LIKE1 (DCL1) with the assistance of a partnering protein, DOUBLE-STRANDED RNA BINDING1 (DRB1) or DRB2.
HIV related pulmonary arterial hypertension: epidemiology in Africa, physiopathology, and role of antiretroviral treatment.
Koulla-Shiro et al., Yaoundé, Cameroon. In Aids Res Ther, 2014
The physiopathology includes cytokines secretion increase which induces dysregulation of endothelial and vascular smooth muscle cell growth and imbalance of endogenous vasodilators and constrictors; HIV viral proteins which induces vascular oxidative stress, smooth myocyte proliferation and migration, and endothelial injury and genetic predisposition due to some major histocompatibility complex alleles, particularly HDL-DR6 and HLA-DR5.
Proline Oxidase (POX) as A Target for Cancer Therapy.
Miltyk et al., Białystok, Poland. In Curr Drug Targets, 2014
POX can also stimulate TRAIL (tumor necrosis factorrelated apoptosis inducing ligand) and DR5 (death receptor 5) expression, resulting in cleavage of procaspase-8 and thus extrinsic apoptotic pathway.
Variation at HLA-DRB1 is associated with resistance to enteric fever.
Khor et al., Thành phố Hồ Chí Minh, Vietnam. In Nat Genet, 2014
We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 × 10(-10)), a marker mapping to the HLA class II region, in proximity to HLA-DQB1 and HLA-DRB1.
Expression of TRAIL and its receptor DR5 and their significance in acute leukemia cells.
Li et al., Zhengzhou, China. In Genet Mol Res, 2014
We investigated the roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor death receptor 5 (DR5) in the onset of acute leukemia and changes in their expression during chemotherapy.
High-resolution HLA-DRB1 genotyping in an Australian inclusion body myositis (s-IBM) cohort: an analysis of disease-associated alleles and diplotypes.
Mastaglia et al., Perth, Australia. In J Neuroimmunol, 2012
epistatic interactions at the HLA-DRB1 locus contribute both to disease susceptibility and to the clinical phenotype in sporadic inclusion body myositis
Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis.
Mellins et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis
Proapoptotic activation of death receptor 5 on tumor endothelial cells disrupts the vasculature and reduces tumor growth.
Ashkenazi et al., San Francisco, United States. In Cancer Cell, 2012
Vascular disruption and antitumor activity required DR5 expression on tumor ECs but not malignant cells. These results establish a therapeutic paradigm for proapoptotic receptor agonists as selective tumor vascular disruption agents
Influence of HLA-DRB1 and HLA-DQB1 alleles on IgG antibody response to the P. vivax MSP-1, MSP-3α and MSP-9 in individuals from Brazilian endemic area.
de Oliveira-Ferreira et al., Rio de Janeiro, Brazil. In Plos One, 2011
HLA-DRB1*04 alleles were associated with high frequency of antibody responses to five out of nine Plasmodium vivax Merozoite Surface Protein-1 (MSP-1), MSP-3alpha and MSP-9 recombinant proteins tested in Rondonia State, Brazil.
A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype.
Busson et al., Paris, France. In Plos One, 2011
Presence of 4 alleles of HLA-DRB in severe acute-kidney-injury patients seems associated with a lower need of renal replacement therapy.
More papers using DRB1 antibodies
cFLIP regulation of lymphocyte activation and development
Banjerdpongchai Ratana et al., In Journal of Hematology & Oncology, 2005
... Mouse monoclonal antibodies to beta-actin, DR4 and DR5 were obtained from Santa Cruz Biotechnology, USA ...
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
Jin Dong-Yan, In PLoS ONE, 2005
... Rabbit polyclonal anti-DR5 antibody was purchased from ProSci Inc (Poway, CA) ...
Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo
Gao Shen et al., In International Journal of Nanomedicine, 2004
... Humanized anti-DR5 mAb was purchased from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Persistent c-FLIP(L) expression is necessary and sufficient to maintain resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in prostate cancer
Szegezdi E et al., In British Journal of Cancer, 2003
... amino acids 114–281, Triskel Therapeutics, Groningen, The Netherlands) DR5-selective mutants D269H, D269H/E195R, agonistic DR4 or DR5 antibodies (Novartis Pharmaceuticals, Basel, Switzerland), recombinant human TNF (PromoCell, Heidelberg, Germany) or agonistic anti-Fas antibody (clone CH-11, MBL International, Woburn, MA, USA) ...
Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis
Liu Pi C. et al., In Journal of Neuro-Oncology, 2003
... as follows: rabbit polyclonal antibody to DR4 (Chemicon International, 1:1,000 dilution), rabbit polyclonal antibody to DR5 (Cell Signaling Technology, 1:1,000 dilution), and ...
CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism
Sadegh-Nasseri Scheherazade et al., In The Journal of Experimental Medicine, 1998
... HLA-DR1 (DR B1*0101) Tg mice (Merck) at 8–10 wk of ...
Correlations between gravitropic curvature and auxin movement across gravistimulated roots of Zea mays
Kamisaka Seiichiro et al., In Journal of Experimental Botany, 1989
... DR5::GUS transgenic plants ( ...
GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants.
Bendahmane Mohammed, In PLoS ONE, 1986
... DRB1, DRB2, DRB3 and DRB5 coding sequences were generated using the Qiagen OneStep RT-PCR kit according ...
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