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DNA-damage regulated autophagy modulator 1

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p53, LC3, CAN, V1a, bcl-2
Papers on DRAM
Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells.
Wu et al., Tainan City, Taiwan. In Int J Oncol, Dec 2015
In addition, SN treatment upregulated nuclear p53 and damage-regulated autophagy modulator (DRAM) and downregulated cytosolic p53 and Tp53-induced glycolysis and apoptosis regulator (TIGAR) expression in J5 cells.
Three-dimensional microenvironment confers enhanced sensitivity to doxorubicin by reducing p53-dependent induction of autophagy.
Menck et al., São Paulo, Brazil. In Oncogene, Nov 2015
Moreover, in the monolayer-cultured cells, DOXO treatment led to increases in p53 and DRAM-1 expression, which is a p53-dependent activator of autophagy that functions in response to DNA damage.
DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose.
Ryan et al., Glasgow, United Kingdom. In Cell Death Differ, Oct 2015
We report here the characterization of a novel autophagy regulator that we have termed DRAM-3 due to its significant homology to damage-regulated autophagy modulator (DRAM-1).
Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors.
Harari et al., Madison, United States. In Mol Cancer Ther, Sep 2015
Several molecules involved in senescence, autophagy, and apoptosis were specifically modulated following the combined AMG 232/radiation treatment, including FoxM1, ULK-1, DRAM, and BAX.
Using Kalman Filtering to Predict Time-Varying Parameters in a Model Predicting Baroreflex Regulation During Head-Up Tilt.
Olufsen et al., In Ieee Trans Biomed Eng, Aug 2015
In addition, we show that the delayed rejection adaptive Metropolis (DRAM) algorithm can be used for predicting parameter uncertainties within the spline methodology, which is compared with the variability obtained with the ETKF.
Substituent and Charge Transfer Effects on Memory Behavior of the Ambipolar Poly(triphenylamine)s.
Liou et al., Taipei, Taiwan. In Acs Appl Mater Interfaces, Aug 2015
The tunable memory properties of the ITO/polymer/Al sandwiched memory devices including DRAM, SRAM, and WORM could be achieved by introducing substituent acceptors with different extent of electronic delocalization and electron-withdrawing intensity into the poly(triphenylamine)s.
Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts.
Kim et al., Suwŏn, South Korea. In Biochim Biophys Acta, Feb 2015
In support of this, it was found that PsA significantly increased the expression of damage-regulated autophagy modulator (DRAM), a p53-induced protein.
XingNaoJing, prescription of traditional Chinese medicine, prevents autophagy in experimental stroke by repressing p53-DRAM pathway.
Chen et al., Guangzhou, China. In Bmc Complement Altern Med, 2014
The mRNA levels and the expression of p53 and its target autophagy gene DRAM (damage-regulated autophagy modulator) were analyzed respectively by Quantitative-RTPCR and Western blot assay.
Effects of damage-regulated autophagy regulator gene on the SGC7901 human gastric cancer cell line.
Xing et al., Suzhou, China. In Oncol Lett, 2014
The aim of this study was to investigate the effects of the adenoviral-mediated autophagy gene, damage-regulated autophagy regulator (DRAM), on the proliferation and autophagy of SGC7901 human gastric cancer cells in vitro.
CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2.
Chen et al., Beijing, China. In Cell Death Dis, 2013
Our results show that ASPP2 induces the expression of damage-regulated autophagy modulator (DRAM), another critical factor that cooperates with free Beclin-1 to induce autophagic apoptosis.
DRAM-1 encodes multiple isoforms that regulate autophagy.
Ryan et al., Glasgow, United Kingdom. In Autophagy, 2012
DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.
p53 and autophagy in cancer: guardian of the genome meets guardian of the proteome.
Ryan, Glasgow, United Kingdom. In Eur J Cancer, 2011
Summarized here are our findings linking p53 to autophagy and how this led to the identification of the human Damage-Regulated Autophagy Modulator (DRAM) family.
Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.
Lazo et al., Salamanca, Spain. In Plos One, 2010
Overexpression of DRAM induces VRK1 downregulation and the opposite effect was observed by its knockdown.
p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment.
Feng, New Brunswick, United States. In Cold Spring Harb Perspect Biol, 2010
Furthermore, p53 transcribes several critical genes regulating the endosomal compartment, including TSAP6, Chmp4C, Caveolin-1, and DRAM, and increases exosome secretion, the rate of endosomal removal of growth factor receptors (e.g., EGFR) from cell surface, and enhances autophagy.
Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy.
Djavaheri-Mergny et al., Châtenay-Malabry, France. In Autophagy, 2010
In this context, p53 regulates, at least partially, JNK activation which in turn modulates autophagy through two distinct mechanisms: on the one hand it promotes Bcl-2 phosphorylation resulting in the dissociation of the Beclin 1-Bcl-2 complex and on the other hand it leads to the upregulation of DRAM (Damage-Regulated Autophagy Modulator), a p53 target gene.
c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells.
Djavaheri-Mergny et al., Châtenay-Malabry, France. In Cancer Res, 2009
c-Jun NH2-terminal kinase as a novel mediator of DRAM protein regulation in Ewing sarcoma cells
Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy.
Ryan et al., Glasgow, United Kingdom. In Cell Cycle, 2009
DRAM is activated by p53 which is required for the ability of p53 to induce autophagy and is also critical for the ability of p53 to induce programmed cell death.
The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins.
Spinella et al., Hanover, United States. In Biochim Biophys Acta, 2007
identified FLJ11259/DRAM as a p53-inducible member of a novel family of transmembrane proteins. FLJ11259/DRAM may be an important modulator of p53 responses in diverse tumor types.
DRAM links autophagy to p53 and programmed cell death.
Ryan et al., Glasgow, United Kingdom. In Autophagy, 2007
DRAM links autophagy to p53 and programmed cell death.
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.
Ryan et al., Glasgow, United Kingdom. In Cell, 2006
Collectively therefore, these studies not only report a stress-induced regulator of autophagy but also highlight the relationship of DRAM and autophagy to p53 function and damage-induced programmed cell death.
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