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Major histocompatibility complex, class II, DR beta 3

HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DRB1, DR3, DR4, HAD, MHC
Papers on DR7
HLA-DRB1 alleles of susceptibility and protection in Iranians with autoimmune hepatitis.
Tajik et al., Tehrān, Iran. In Hum Immunol, Feb 2016
The aim of this study was to determine the frequency of HLA-DRB1 alleles in Iranian patients with AIH and investigate the association between HLA alleles and the different types of the disease.
Next generation sequencing reveals that HLA-DRB3, -DRB4 and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes.
Better Diabetes Diagnosis (BDD) Study Group et al., Malmö, Sweden. In Diabetes, Feb 2016
UNASSIGNED: The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear.
A novel "humanized mouse" model for autoimmune hepatitis and the association of gut microbiota with liver inflammation.
Wen et al., Gent, Belgium. In Hepatology, Nov 2015
It is known that AIH, both types 1 and 2, is strongly linked to the human leukocyte antigen (HLA) alleles -DR3, -DR4, and -DR7.
Suggestive evidence of a role of HLA-DRB4 mismatches in the outcome of allogeneic hematopoietic stem cell transplantation with HLA-10/10-matched unrelated donors: a French-Swiss retrospective study.
Dubois et al., Lyon, France. In Bone Marrow Transplant, Oct 2015
We have conducted a retrospective study on 251 patients from three centers in France and Switzerland between 2004 and 2010 with the goal to evaluate the impact of HLA-DRB3/B4/B5 allele mismatching after HLA-10/10-matched unrelated allogeneic hematopoietic stem cell transplantation (HSCT).
Association of HLA-DQA1 and -DQB1 alleles with type I diabetes in Arabs: a meta-analyses.
Al Ali et al., Dubai, United Arab Emirates. In Tissue Antigens, Jul 2015
The haplotypes DR7 and DR11 were strongly suggested to be protective in Arabs.
No gender differences in the frequencies of HLA-DRB3/B4/B5 heterozygotes in newborns and adults in Koreans.
Park et al., Seoul, South Korea. In Genes Genet Syst, 2011
There are no significant differences in the HLA-DRB3/B4/B5 homozygosity and heterozygosity rates between Korean males and females in both newborns and adults.
The association of sporadic inclusion body myositis and Sjögren's syndrome in carriers of HLA-DR3 and the 8.1 MHC ancestral haplotype.
Mastaglia et al., Perth, Australia. In Clin Neurol Neurosurg, 2011
All patients with sporadic inclusion body myositis carried the HLA-DRB1*0301 allele, or its equivalent HLA-DR3 serological specificity
Fulminant type 1 diabetes in China: a case report and review of the literature.
Shen et al., Hangzhou, China. In J Zhejiang Univ Sci B, 2010
Human leukocyte antigen-DR7 (HLA-DR7) was available in this case.
Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules.
Mellins et al., Ulm, Germany. In Immunology, 2010
CatG cleaves human leukocyte antigen (HLA)-DR in vitro. Cleavage occurred on the loop between fx1 and fx2 of the membrane-proximal beta2 domain. In vivo, however, the CatG cleavage site is sterically inaccessible or masked by associated molecules.
HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus.
DPV-Wiss Study Group and the German Competence Network Diabetes Mellitus et al., Ulm, Germany. In Eur J Endocrinol, 2010
IA2 positivity was associated with HLA-DR4/X and HLA-DR3/4 positivity, and hypothyroidism was linked to HLA-DR4/4.
[An evaluation of HLA class 2 alleles and anti-islet antibodies as evidence for non-autoimmune diabetes in Wolfram syndrome].
Młynarski et al., Łódź, Poland. In Pediatr Endocrinol Diabetes Metab, 2009
Patients with Wolfram syndrome have a different profile of the HLA antigens with the presence of DR2, DQw1 and DRB3/4 allele and are negative for diabetes-related autoantibodies
Bacterial triggers and autoimmune rheumatic diseases.
Doria et al., Würzburg, Germany. In Clin Exp Rheumatol, 2008
Carditis is the most serious manifestation of RF and HLA-DR7 is predominantly observed in the development of valvular lesions.
Rheumatic fever and rheumatic heart disease: genetics and pathogenesis.
Kalil et al., São Paulo, Brazil. In Scand J Immunol, 2007
Among these alleles, HLA-DR7 is predominantly observed in different ethnicities and is associated with the development of valvular lesions in RHD patients.
Human leukocyte antigens and susceptibility to tuberculosis: a meta-analysis of case-control studies.
Cabane et al., Paris, France. In Int J Tuberc Lung Dis, 2006
P = 0.002), and DR7 antigens (OR 0.65, 95% CI 0.53-0.80,
[Distribution and frequency of HLA alleles and haplotypes in Brazilians with type 1 diabetes mellitus].
LeMaire et al., Nueva San Salvador, El Salvador. In Arq Bras Endocrinol Metabol, 2006
Immunogenetic susceptibility to DM1 in Brazilians was associated with HLA-DRB1*03, -DRB*04, -DQB1*0201, -DQB1*0302 alleles, and protection against DM1 was associated with HLA-DQB1*0602, -DQB1*0301 alleles and -DR2 and -DR7 antigens.
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir.
Christiansen et al., Perth, Australia. In Lancet, 2002
and the HLA-DR7 and HLA-DQ3 combination was found in 13 (72%) of hypersensitive and five (3%) of tolerant patients (73 [20-268], p(c)<0.0001
HLA and hepatitis B infection.
Batchelor et al., Doha, Qatar. In Lancet, 1994
In both studies, there was a significant deficiency of HLA-DR2 and an excess of HLA-DR7 in patients with chronic persistent infection with hepatitis B virus.
Lack of response to recombinant hepatitis B vaccine in nonresponders to the plasma vaccine.
Ettenger et al., Pasadena, United States. In Jama, 1988
In these 25 subjects HLA subtyping showed a high prevalence of DR7, B8, and the combinations of DR3 and DR7 and DR4 and DR7.
The heavy chain of human B-cell alloantigen HLA-DS has a variable N-terminal region and a constant immunoglobulin-like region.
Silver et al., In Nature, 1983
We have now isolated a cDNA clone from a DR7 cell line that contains the entire coding sequence for the DS alpha subunit and have compared its predicted amino acid sequence with that previously deduced from a DS alpha cDNA clone isolated from a DR4,w6 cell line.
Extended MHC haplotypes in 21-hydroxylase-deficiency congenital adrenal hyperplasia: shared genotypes in unrelated patients.
Alper et al., In Lancet, 1983
The haplotype containing this rare set of complement alleles always carried the rare HLA allele, HLA-Bw47, usually carried HLA-A3, and almost always had the alleles HLA-Cw6, HLA-DR7, and the glyoxalase I (GLO) allele GLO1.
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