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Developmental pluripotency associated 4

DPPA4, developmental pluripotency associated-4
Top mentioned proteins: Dppa2, Sox2, Nanog, CAN, Histone
Papers on DPPA4
Copy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma.
Ventelä et al., Turku, Finland. In J Oral Pathol Med, Nov 2015
METHODS: CIP2A and DPPA4 copy number alterations and expression were analysed by fluorescence in situ hybridisation (FISH) and immunohistochemistry (IHC) in different cell lines and a tissue microarray of 52 HNSCC patients.
Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development.
Okano et al., Tokyo, Japan. In Dev Biol, May 2015
Initially we characterized adult spermatogonia into two main classes; mitotically active C-KIT(+)Ki67(+) cells and mitotically quiescent SALL4(+)PLZF(+)LIN28(+)DPPA4(+) cells.
The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.
Cagney et al., Dublin, Ireland. In Sci Rep, 2014
Notably, a sub-network of proteins associated with the establishment and maintenance of pluripotency (NANOG, OCT4, PATZ1, and the developmental regulator DPPA4) were found to independently interact with PCGF1 in a subsequent round of physical interaction mapping experiments.
Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity.
Luo et al., Århus, Denmark. In Stem Cell Res Ther, 2014
The iPSC-MSCs and the tri-lineage differentiated cells (osteoblasts, chondrocytes, adipocytes) all lack expression of "stemness" genes: OCT4, SOX2, GDF3, CRIPTO, UTF1, DPPA4, DNMT3B, LIN28a, and SAL4.
Developmental pluripotency-associated 4: a novel predictor for prognosis and a potential therapeutic target for colon cancer.
Tang et al., Shanghai, China. In J Exp Clin Cancer Res, 2014
BACKGROUNDS: Developmental pluripotency-associated 4 (Dppa4) gene plays an important role in self-renewal and pluripotency sustainability in embryonic stem cells.
Progress on ovine lentivirus and its resistant genes.
Wang et al., Hangzhou, China. In Yi Chuan, 2014
Here, we review the progress of E35K mutation in sheep TMEM154 gene and its effects on resistance to MVV, and other lentivirusresistant genes including zinc finger cluster, chemokine reveptor 5 (CCR5), tripartite motif-containing 5 alpha (TRIM5Α), apolipoprotein B mRNA-editing catalytic polypetide like 3 (APOBEC3), developmental pluripotencyassociated 2 (DPPA2) and DPPA4.
The expressions of stem cell markers: Oct4, Nanog, Sox2, nucleostemin, Bmi, Zfx, Tcl1, Tbx3, Dppa4, and Esrrb in bladder, colon, and prostate cancer, and certain cancer cell lines.
Ghadimi et al., Sanandaj, Iran. In Anat Cell Biol, 2014
Here, we examine the expressions of self-renewal regulatory factors Oct4, Nanog, Sox2, nucleostemin, Zfx, Esrrb, Tcl1, Tbx3, and Dppa4 in tissue samples of colon, prostate, and bladder carcinomas as well as cancer cell lines HT-29, Caco-2, HT-1376, LNCaP, and HepG2.
Making gametes from pluripotent stem cells--a promising role for very small embryonic-like stem cells.
Bhilawadikar et al., Mumbai, India. In Reprod Biol Endocrinol, 2013
Both VSELs and PGCs are pluripotent, relatively quiescent because of epigenetic modifications of parentally imprinted genes loci like Igf2-H19 and KCNQ1p57, share several markers like Stella, Fragilis, Mvh, Dppa2, Dppa4, Sall4, Blimp1 and functional receptors.
An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator.
Seo et al., Seoul, South Korea. In Nat Commun, 2013
Such DNA methylation-driven control is the key to the regulation of ESC-pluripotency genes, including Dppa4, Dppa5a and Esrrb.
Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes.
Knoepfler et al., Davis, United States. In Stem Cells, 2013
From this screen, we identified not only known oncogenes but also intriguingly the key pluripotency factor, DPPA4 (developmental pluripotency-associated four) that encodes a DNA binding SAP domain-containing protein.
Defining the nature of human pluripotent stem cell progeny.
Lowry et al., Los Angeles, United States. In Cell Res, 2012
While pluripotent genes (OCT4, SOX2, REX1, and NANOG) appeared to be silenced immediately upon differentiation from hPSCs, genes normally unique to early embryos (LIN28A, LIN28B, DPPA4, and others) were not fully silenced in hPSC derivatives.
Genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus.
Knowles et al., Pullman, United States. In Plos One, 2011
Genes in regions associated with odds of infection included DPPA2/DPPA4 (empirical P=0.006), and SYTL3 (P=0.051).
Essential roles of ECAT15-2/Dppa2 in functional lung development.
Yamanaka et al., Kyoto, Japan. In Mol Cell Biol, 2011
Embryonic stem cell (ESC)-associated transcript 15-1 (ECAT15-1) and ECAT15-2, also known as developmental pluripotency-associated 4 (Dppa4) and Dppa2, respectively, are enriched in mouse ESCs and preimplantation embryos, and their genes encode homologous proteins with a common DNA binding domain known as the SAP motif.
Investigating the role of FGF-2 in stem cell maintenance by global phosphoproteomics profiling.
Muñoz et al., Utrecht, Netherlands. In Proteomics, 2011
Wnt and PI3K/AKT), hESC-associated proteins such as SOX2, RIF1, SALL4, DPPA4, DNMT3B and 53 proteins that are target genes of the pluripotency transcription factors SOX2, OCT4 and NANOG.
Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells.
Ikeda et al., Rochester, United States. In Stem Cell Res Ther, 2010
The global gene-expression profiles demonstrated the induction of endogenous pluripotent genes, such as LIN28, TERT, DPPA4, and PODXL, in derived iPSCs.
The pluripotency-associated gene Dppa4 is dispensable for embryonic stem cell identity and germ cell development but essential for embryogenesis.
Fehling et al., Ulm, Germany. In Mol Cell Biol, 2009
Dppa4 is completely dispensable for ES cell identity and germ cell development. Instead, loss of Dppa4 in mice results in late embryonic/perinatal death and striking skeletal defects with partial penetrance.
Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays.
Rizzino et al., Omaha, United States. In J Cell Physiol, 2008
Thsi study identifies DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays.
Developmental pluripotency-associated 4 (DPPA4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage.
Teraoka et al., Tokyo, Japan. In J Biol Chem, 2007
DPPA4 is a nuclear factor associated with active chromatin
Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line.
Western et al., Cambridge, United Kingdom. In Stem Cells, 2007
Study of expression and function of pluripotent markers such as Dppa2 and Dppa4 is likely to unveil new aspects of the regulation of pluripotency and germ line development in mammals.
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