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DPH2 Dph2p

DPH2, Dph2p, diphthamide biosynthesis-like protein-2, diphthamide biosynthesis protein-2, DPH2L2
This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: OVCA1, Elongation Factor 2, CAN, ACID, Urm1
Papers using DPH2 antibodies
Crystallography & NMR system: A new software suite for macromolecular structure determination
Lin Hening et al., In Nature, 1997
... Cloning and localization of a human diphthamide biosynthesis-like protein-2 gene,DPH2L2 ...
Papers on DPH2
Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor.
Brinkmann et al., Penzberg, Germany. In Proc Natl Acad Sci U S A, Sep 2015
Complete inactivation of DPH1, DPH2, DPH4, and DPH5 generated viable cells without diphthamide.
A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells.
Medico et al., Torino, Italy. In Sci Rep, 2014
The marker (DT(R)) consists of a primary microRNA sequence engineered to downregulate the ubiquitous DPH2 gene, a key enzyme for the biosynthesis of the DT target diphthamide.
Genetic modifiers of neurofibromatosis type 1-associated café-au-lait macule count identified using multi-platform analysis.
Stewart et al., Rockville, United States. In Plos Genet, 2014
Two correlated, common SNPs (rs4660761 and rs7161) between DPH2 and ATP6V0B were significantly associated with the CALM count.
Pharmacokinetics and organ distribution of diarylheptanoid phytoestrogens from Curcuma comosa in rats.
Sripanidkulchai et al., Khon Kaen, Thailand. In J Nat Med, 2012
HPLC was used to measure the concentration of three major compounds, (6E)-1,7-diphenylhept-6-en-3-one (DPH1), (4E,6E)-1,7-diphenylhepta-4,6-dien-3-ol (DPH2), and (6E)-1,7-diphenylhept-6-en-3-ol (DPH3), which were found to be present in the blood and tissues and were subsequently used as markers.
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.
Jackson et al., Edinburgh, United Kingdom. In J Cell Sci, 2008
Sequence homologues of these genes are present in all sequenced eukaryotic genomes and, in higher eukaryotes, there is functional evidence for DPH1, DPH2, DPH3 and DPH5 acting in diphthamide biosynthesis.
OVCA1: tumor suppressor gene.
Behringer et al., Taipei, Taiwan. In Curr Opin Genet Dev, 2005
OVCA1 appears to be the homolog of yeast DPH2, which participates in the first biosynthetic step of diphthamide, by modification of histidine on translation elongation factor 2 (EF-2).
Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification.
Schaffrath et al., Halle, Germany. In Mol Microbiol, 2003
Using TAP tagging, Kti11p contacts Elongator and translational proteins (Rps7Ap, Rps19Ap Eft2p, Yil103wp, Dph2p).
Cloning and localization of a human diphthamide biosynthesis-like protein-2 gene, DPH2L2.
Godwin et al., Philadelphia, United States. In Genomics, 1998
Sequence analysis of the candidate tumor suppressor OVCA1 revealed extensive sequence identity and similarity to proteins from a diverse number of species, including the yeast diphthamide biosynthesis protein-2, dph2, which suggested that OVCA1 may be the human homologue to this yeast gene.
A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3.
Deaven et al., Saint Louis, United States. In Cancer Lett, 1996
This highly conserved gene has significant sequence similarity to a yeast gene of unknown function and to one of the yeast enzymes in the diphthamide synthetic pathway, DPH2, that has a role in global protein synthesis regulation.
Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene.
Collier et al., Boston, United States. In Gene, 1993
A gene involved in diphthamide biosynthesis, DPH2, was cloned from Saccharomyces cerevisiae by complementation of a diphthamide mutant.
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