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Docking protein 5

Dok5, IRS6
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Dok-1, Insulin, Dok-4, CAN, PTB
Papers on Dok5
The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.
Feghali-Bostwick et al., Pittsburgh, United States. In Plos One, 2013
DOK5 is a tyrosine kinase substrate associated with intracellular signaling.
Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis.
Peng et al., Beijing, China. In Neurosci Lett, 2013
Because NT-3 and its receptor, TrkC, are strongly expressed by sensory neurons, we measured the expression of Dok5 and TrkC in the developing mouse spinal cord and dorsal root ganglia (DRG).
Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study.
Arnett et al., Saint Louis, United States. In Lipids, 2013
and RUNX3 (1p36) with NMR-HDLs; and DOK5-CBLN4-MC3R (20q13), NELL1 (11p15.1),
Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia.
Kivisild et al., Tartu, Estonia. In Am J Hum Genet, 2012
Among such candidates of positive selection in India are MSTN and DOK5, both of which have potential implications in lipid metabolism and the etiology of type 2 diabetes.
Exploring the evolutionary relationship of insulin receptor substrate family using computational biology.
Hsu et al., Vellore, India. In Plos One, 2010
Insulin receptor substrate (IRS) harbors proteins such as IRS1, IRS2, IRS3, IRS4, IRS5 and IRS6.
Integrative epigenomic and genomic analysis of malignant pheochromocytoma.
Wadelius et al., Uppsala, Sweden. In Exp Mol Med, 2010
Potential oncogenes detected among those were GNAS, INSM1, DOK5, ETV1, RET, NTRK1, IGF2, and the H3K27 trimethylase gene EZH2.
A genome-wide association study of amygdala activation in youths with and without bipolar disorder.
McMahon et al., Bethesda, United States. In J Am Acad Child Adolesc Psychiatry, 2010
Although preliminary, these data suggest that DOK5 and perhaps several other genes influence the magnitude of amygdala activation during face processing, particularly in those with BD.
Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway.
Peng et al., Beijing, China. In J Mol Cell Cardiol, 2009
FOXO3a, the PI3K/PKB downstream substrate, acts as a transcriptional repressor to inhibit the expression of Dok-5.
Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population.
Bharadwaj et al., Delhi, India. In Bmc Med Genet, 2009
identified DOK5 as a novel susceptibility gene for obesity and type 2 diabetes in North Indian subjects
Detection of homo- or hetero-association of Doks by fluorescence resonance energy transfer in living cells.
He et al., Shanghai, China. In Mol Imaging Biol, 2009
RESULTS: By using fluorescence resonance energy transfer technology, we demonstrated, for the first time to our knowledge, that Dok5 and Dok1 could form homomeric and heteromeric associations in living cells.
Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells.
O'Byrne et al., Dublin, Ireland. In Clin Lung Cancer, 2008
Two new members of this family have recently been isolated: IRS5/Dok4 and IRS6/Dok5.
Constitutive plasma membrane targeting and microdomain localization of Dok5 studied by single-molecule microscopy.
He et al., Shanghai, China. In Biophys Chem, 2008
In the present study, single-molecule fluorescence microscopy was used to examine the characteristics of plasma membrane targeting and microdomain localization of enhanced yellow fluorescent protein (eYFP)-tagged wild-type Dok5 and its variants in living Chinese hamster ovary (CHO) cells.
Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation.
Peng et al., Beijing, China. In Cell Signal, 2006
In this report, we identified Dok5, a member of Dok family, as a new substrate of TrkB/C receptors.
Molecular basis of distinct interactions between Dok1 PTB domain and tyrosine-phosphorylated EGF receptor.
He et al., Shanghai, China. In J Mol Biol, 2004
Using yeast two-hybrid and biochemical binding assays, we show that only the PTB domain from Dok1 but not Dok4 or Dok5 can selectively bind to two known tyrosine phosphorylation sites at Y1086 and Y1148 in EGFR.
Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.
Shoelson et al., Boston, United States. In J Biol Chem, 2003
IRS5/DOK4 and IRS6/DOK5 represent two new signaling proteins with potential roles in insulin and IGF-1 action
DOK4 and DOK5: new Dok-related genes expressed in human T cells.
Nun├Ęs et al., Marseille, France. In Genes Immun, 2003
DOK5 expression in human T cells, its genomic structure characterized, and its regulation upon T cell activation has been demonstrated.
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