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Docking protein 2, 56kDa

Dok-2, DokR, downstream of tyrosine kinase 2, p56dok-2
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Dok-1, GAP, Src, CAN, Nck
Papers on Dok-2
Plasma Autoantibodies Associated with Basal-like Breast Cancers.
LaBaer et al., Warsaw, Poland. In Cancer Epidemiol Biomarkers Prev, Sep 2015
RESULTS: We identified 13 AAbs (CTAG1B, CTAG2, TP53, RNF216, PPHLN1, PIP4K2C, ZBTB16, TAS2R8, WBP2NL, DOK2, PSRC1, MN1, TRIM21) that distinguished BLBC from controls with 33% sensitivity and 98% specificity.
Expression and significance of DOK2 in colorectal cancer.
Peng et al., Wuhan, China. In Oncol Lett, 2015
A reduction in the levels of docking protein 2 (DOK2) expression has previously been reported in lung adenocarcinoma and gastric cancer, indicating that this protein acts as a tumor suppressor in solid tumors.
Intracellular TCR-signaling pathway: novel markers for lymphoma diagnosis and potential therapeutic targets.
Marafioti et al., London, United Kingdom. In Am J Surg Pathol, 2014
With this background, we evaluated the expression of 5 intracellular proteins-GADS, DOK2, SKAP55, ITK, and PKCα-involved in T-cell receptor signaling in normal and neoplastic hematologic tissue samples, using antibodies raised against fixation-resistant epitopes of the 5 molecules.
Dok1 and Dok2 proteins regulate natural killer cell development and function.
Nunès et al., Marseille, France. In Embo J, 2014
Here, we show that the cytoplasmic signaling molecules Dok1 and Dok2 are tyrosine phosphorylated upon NK-cell activation.
Dok2 likely down-regulates Klf1 in mouse erythroleukemia cells.
Sugiyama et al., Fukuoka, Japan. In Anticancer Res, 2014
BACKGROUND/AIM: Docking protein 2 (Dok2) is an adapter protein which is involved in hematopoiesis.
mRNA expression of DOK1-6 in human breast cancer.
Mokbel et al., London, United Kingdom. In World J Clin Oncol, 2014
RESULTS: DOK-2 and DOK-6 expression decreased with increasing TNM stage.
Maternal preconception body mass index and offspring cord blood DNA methylation: exploration of early life origins of disease.
Wang et al., Chicago, United States. In Environ Mol Mutagen, 2014
Some of the other CpG site annotated genes appear to be critical to the development of cancers and cardiovascular diseases (i.e., WNT16, C18orf8, ANGPTL2, SAPCD2, ADCY3, PRR16, ERBB2, DOK2, PLAC1).
Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia.
Lynch et al., Cork, Ireland. In Mol Cell Neurosci, 2013
The adaptor proteins, downstream of kinase (Dok)1 and Dok2, are known to have a role in negatively regulating the Ras-ERK signaling cascade, with downstream consequences on pro-inflammatory cytokine expression.
Loss of DOK2 induces carboplatin resistance in ovarian cancer via suppression of apoptosis.
Lucito et al., United States. In Gynecol Oncol, 2013
Of the genes identified in the screen we further characterized one gene, docking protein 2 (DOK2), an adapter protein downstream of tyrosine kinase, to determine if we could elucidate the mechanism by which it increased resistance.
DOK2 inhibits EGFR-mutated lung adenocarcinoma.
Pandolfi et al., Boston, United States. In Plos One, 2012
Recently, we identified DOK2 as a lung adenocarcinoma tumor suppressor gene.
Pattern-recognition receptor signaling regulator mRNA expression in humans and mice, and in transient inflammation or progressive fibrosis.
Lech et al., München, Germany. In Int J Mol Sci, 2012
We therefore determined the mRNA expression levels of A20, CYLD, DUBA, ST2, CD180, SIGIRR, TANK, SOCS1, SOCS3, SHIP, IRAK-M, DOK1, DOK2, SHP1, SHP2, TOLLIP, IRF4, SIKE, NLRX1, ERBIN, CENTB1, and Clec4a2 in human and mouse solid organs.
Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma.
Masoudi-Nejad et al., Tehrān, Iran. In Plos One, 2012
DLGAP5, BIRC5, PSMD2, Src, TTK, SENP2, PSMD2, DOK2, FUS and etc.) in the modules.
DOK2 as a marker of poor prognosis of patients with gastric adenocarcinoma after curative resection.
Doki et al., Ōsaka, Japan. In Ann Surg Oncol, 2012
DOK2 is a marker of poor prognosis in patients with gastric cancer after curative resection
The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling.
Cambier et al., Denver, United States. In Immunol Lett, 2012
Studies using SHIP-1 shRNA, knockout mice and decoy inhibitors further indicate that CD4-mediated inhibition of TCR-mediated T cell activation is SHIP-1 and Dok-1/2 dependent, and involves SHIP-1 hydrolysis of Phosphatidylinositol 3,4,5-trisphosophate
Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts.
Noda et al., Tokyo, Japan. In J Cell Physiol, 2011
Dok-1 and Dok-2 deficiency induces osteopenia by activation of osteoclasts.
Mutational and expressional analysis of a haploinsufficient tumor suppressor gene DOK2 in gastric and colorectal cancers.
Lee et al., In Apmis, 2011
data indicate that DOK2 is altered in gastric (GC) and colorectal cancers (CRC) by loss of expressions; data indicate that somatic mutation of DOK2 may be rare in GC, CRC, breast cancer, prostate cancer and liver cancer
Mutational analysis of DOK2 tumor suppressor gene in acute leukemias.
Lee et al., In Leuk Res, 2011
Data indicate there was no evidence of DOK2 somatic mutation in the leukemias analyzed.
Haplo-insufficiency: a driving force in cancer.
Pandolfi et al., Boston, United States. In J Pathol, 2011
Due to the challenges of identifying haplo-insufficient TSGs by human genetics analysis alone, mouse models play a pivotal role in firmly establishing the haplo-insufficiency of a gene, as in the recent identification of DOK2 as a haplo-insufficient lung TSG.
Identification of DOK genes as lung tumor suppressors.
Pandolfi et al., Boston, United States. In Nat Genet, 2010
Identification of DOK genes as lung tumor suppressors.
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product.
Veillette et al., Montréal, Canada. In Nat Immunol, 2001
This signal involves the SH2 domain--containing inositol phosphatase (SHIP); the adaptor molecules Dok2, Dok1 and Shc; and Ras GTPase--activating protein RasGAP.
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