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Major histocompatibility complex, class II, DO beta

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, ACID, CAN, MHC, TRIM32
Papers on DOB
An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis.
Alfredsson et al., Stockholm, Sweden. In Rheumatology (oxford), Jan 2016
After adjusting for HLA-DRB1 shared epitope, 15 smoking-SNP pairs remained significant for ACPA-positive RA, with 8 of these replicated (loci: BTNL2, HLA-DRA, HLA-DRB5, HLA-DQA1, HLA-DOB and TAP2).
Functional relevance for type 1 diabetes mellitus-associated genetic variants by using integrative analyses.
Lei et al., Suzhou, China. In Hum Immunol, Oct 2015
Of the 9 eQTL genes, 6 (TAP2, HLA-DOB, HLA-DQB1, HLA-DQA1, HLA-DRB5 and CTSH) were differentially expressed in type 1 DM-associated related cells.
Rapid Histone-Catalyzed DNA Lesion Excision and Accompanying Protein Modification in Nucleosomes and Nucleosome Core Particles.
Greenberg et al., Baltimore, United States. In J Am Chem Soc, Oct 2015
The oxidized abasic lesion 5'-(2-phosphoryl-1,4-dioxobutane) (DOB) is an electrophilic product of the C5'-radical.
Effect of dobutamine on lung aquaporin 5 in endotoxine shock-induced acute lung injury rabbit.
Qin et al., Nanjing, China. In J Thorac Dis, Aug 2015
Seventy male New Zealand white rabbits were randomly divided into seven groups: sham group, ALI group, dobutamine low-dose group [group ALI + Dob (L)], dobutamine medium-dose group [group ALI + Dob (M)], dobutamine high-dose group [group ALI + Dob (H)], ALI + Dob (H) + ICI group and sham + ICI group.
Association of polymorphisms in HLA antigen presentation-related genes with the outcomes of HCV infection.
Su et al., Nanjing, China. In Plos One, 2014
Our study implicated that TAP2, HLA-DOA, HLA-DOB, and tapasin loci were novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population.
Beta-1-adrenergic receptors mediate Nrf2-HO-1-HMGB1 axis regulation to attenuate hypoxia/reoxygenation-induced cardiomyocytes injury in vitro.
Jiang et al., Wuhan, China. In Cell Physiol Biochem, 2014
METHODS: The neonatal cultured cardiomyocytes were concentration-dependently pretreated by dobutamine (DOB), a selective β1-adrenergic receptor agonist, in the absence and/or presence of LY294002 (a phosphatidylinositol 3-kinase (PI3K) inhibitor), SB203580 (a p38mitogen-activated-protein kinase (p38MAPK) inhibitor), Nrf2siRNA and HO-1siRNA, respectively, and then treated by H/R.
Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphisms with Schizophrenia in Chinese Han Population.
Yue et al., Beijing, China. In Plos One, 2014
Moreover, 12 genes (HLA-A, HLA-C, HLA-DOB, HLA-DPB1, HLA-DQA2, HLA-DRB1, MPZ, CD276, NLGN1, NRCAM, CLDN1 and ICAM3) were modestly significantly associated with schizophrenia (P<0.01).
[Detection of cytochrome P4502C19 gene polymorphism to optimize therapy of acid-dependent diseases].
Rabotyagova et al., In Klin Med (mosk), 2014
12 (37.5%) of them had fast-type metabolism (mean delta over base (DOB) 4.725%+-0.3),
β₁-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation.
Wang et al., Guangzhou, China. In Crit Care, 2014
RESULTS: LPS induced apoptosis in adult mouse ventricular myocytes, dobutamine (DOB), a β₁-AR agonist, promoted apoptosis, caspase-8, 9 and 3 activation and increased cytosolic Ca(2+) concentration in LPS-challenged cardiomyocytes.
Comparison of immunological characteristics of peripheral, splenic and tonsilar naïve B cells by differential gene expression meta-analyses.
Ruxrungtham et al., Bangkok, Thailand. In Asian Pac J Allergy Immunol, 2012
These included enhanced expressions of CD27, CR2, EGR1, GADD45B, ICAM1, ICOSLG, IGHA, IL6, MMP9, SAMSN1, SMAD7, TNFAIP3, but reduced HLA-DOB expression.
Clinical toxicology of newer recreational drugs.
Thomas et al., Newcastle upon Tyne, United Kingdom. In Clin Toxicol (phila), 2011
5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT), 2,5-dimethoxy-4-bromoamfetamine (DOB)) are serotonin receptor agonists.
Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis.
Cunliffe et al., Sheffield, United Kingdom. In Int J Dev Biol, 2010
Hdac1 is required for expression of erm and fgf20a in rhombomeres; Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch signalling activity
Fgfs control homeostatic regeneration in adult zebrafish fins.
Poss et al., Durham, United States. In Development, 2008
fgf20a is expressed in the intact fin and is required for homeostasis.
fgf20 is essential for initiating zebrafish fin regeneration.
Keating et al., Boston, United States. In Science, 2006
fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation
'Ovar-Mhc' - ovine major histocompatibility complex: structure and gene polymorphisms.
Murray et al., Palmerston North, New Zealand. In Genet Mol Res, 2005
The class II region is better characterised, with evidence of one DRA, four DRB (one coding and three non-coding), one DQA1, two DQA2, and one each of the DQB1, DQB2, DNA, DOB, DYA, DYB, DMA, and DMB genes in the region.
Identification of a novel HLA-DOB-allele, DOB*010103, by sequence-based typing in the Korean population.
Oh et al., Seoul, South Korea. In Tissue Antigens, 2005
A new DOB allele, DOB*010103, was identified in the Korean population during sequence-based HLA-DOB typing.
Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation.
Denzin et al., New York City, United States. In J Immunol, 2004
In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation.
Hallucinogens and serotonergic mechanisms.
Sanders-Bush et al., Richmond, United States. In Nida Res Monogr, 1991
For a series of DOB-related agents, 5-HT2(KET) affinity can be modeled by the lipophilicity of the 4-position substituent; lipophilicity alone does not completely account for the affinity of 5-HT2 agonists.
A new human HLA class II-related locus, DM.
Trowsdale et al., London, United Kingdom. In Nature, 1991
We have isolated two new class II-like complementary DNA sequences, RING6 and RING7, which map between the HLA-DNA and -DOB loci.
Site-selective serotonin agonists as discriminative stimuli.
Glennon, Richmond, United States. In Psychopharmacol Ser, 1987
Certain 4-substituted 1-(2,5-dimethoxyphenyl)-2-aminopropanes such as DOM (4-methyl), DOB (4-bromo), and DOI (4-iodo) appear to be 5-HT2-selective agonists and serve as effective training drugs in rats.
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