gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


DNA topoisomerase I, TOP1
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, POLYMERASE, ACID, V1a
Papers using DNA topoisomerase I antibodies
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
Korolev Sergey, In PLoS ONE, 2007
... Top1 (M0301S) was purchased from New England BioLabs.
Cellular roles of DNA topoisomerases: a molecular perspective.
Bielinsky Anja-Katrin, In PLoS ONE, 2001
... Antibodies for Ring1A, Top1, Top2α and Top2β were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on DNA topoisomerase I
Evaluation of two novel barcodes for species recognition of opportunistic pathogens in Fusarium.
Levesque et al., Utrecht, Netherlands. In Fungal Biol, Feb 2016
We demonstrate the potential of two recently discovered DNA barcode loci, topoisomerase I (TOP1) and phosphoglycerate kinase (PGK), in combination with other routinely used markers such as TEF1, in an analysis of 144 Fusarium strains belonging to 52 species.
The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase I poison in conjunction with DNA replication and RNA transcription.
Iwabuchi et al., Kanazawa, Japan. In Genes Genet Syst, Feb 2016
Camptothecin (CPT) inhibits DNA topoisomerase I (Top1) through a non-catalytic mechanism that stabilizes the Top1-DNA cleavage complex (Top1cc) and blocks the DNA re-ligation step, resulting in the accumulation in the genome of DNA single-strand breaks (SSBs), which are converted to secondary strand breaks when they collide with the DNA replication and RNA transcription machinery.
mir-24 activity propagates stress-induced senescence by down regulating DNA topoisomerase 1.
Jansen-Dürr et al., Innsbruck, Austria. In Exp Gerontol, Jan 2016
DNA topoisomerase I (TOP1), an enzyme controlling DNA topology, was identified as a target of mir-24, whose expression was induced by oxidative stress.
Bromodomain and hedgehog pathway targets in small cell lung cancer.
Teicher et al., Frederick, United States. In Cancer Lett, Jan 2016
Myc status, TOP2A, TOP2B and TOP1 mRNA expression or topoisomerase 1 and topoisomerase 2 protein did not account for the range in the sensitivity to the drugs.
Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
Fukushima et al., Tokyo, Japan. In Int J Mol Med, Jan 2016
In this study, primary tumors obtained from 1,129 patients with colorectal cancer were used to measure the mRNA expression levels of the following genes associated with the effects of standard chemotherapy for colorectal cancer: 5-fluorouracil (5-FU)-related thymidylate synthase (TYMS), dihydropyrimidine dehydrogenase (DPYD) and thymidine phosphorylase (TYMP); folate-related dihydrofolate reductase (DHFR), folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH); irinotecan-related topoisomerase I (TOP1); oxaliplatin-related excision repair cross-complementing 1 (ERCC1); biologic agent-related vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR).
Improving Antitumor Activity with N-Trimethyl Chitosan Entrapping Camptothecin in Colon Cancer and Lung Cancer.
Peng et al., In J Nanosci Nanotechnol, Sep 2015
Camptothecin (CPT) exerts very strong antitumor activities by suppressing the activity of DNA topoisomerase I, but its application is greatly limited owing to its low solubility and the instability of the active lactone form.
Perspectives on biologically active camptothecin derivatives.
Lee et al., Lanzhou, China. In Med Res Rev, Jul 2015
Camptothecins (CPTs) are cytotoxic natural alkaloids that specifically target DNA topoisomerase I. Research on CPTs has undergone a significant evolution from the initial discovery of CPT in the late 1960s through the study of synthetic small-molecule derivatives to investigation of macromolecular constructs and formulations.
Ligand-dependent enhancer activation regulated by topoisomerase-I activity.
Rosenfeld et al., San Diego, United States. In Cell, Mar 2015
Using dihydrotestosterone (DHT)-induced binding of androgen receptor (AR) to prostate cancer cell enhancers as a model, we show rapid recruitment, within minutes, of DNA topoisomerase I (TOP1) to a large cohort of AR-regulated enhancers.
Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy.
Her et al., Pullman, United States. In Biomolecules, 2014
In this article, we discuss the characteristics of topoisomerase (DNA) I (TOP1) and its inhibitors, as well as the underlying DNA repair pathways and the use of TOP1 inhibitors in cancer therapy.
Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.
van Waardenburg et al., Birmingham, United States. In Drug Metab Rev, 2014
Tdp1 was discovered for its ability to hydrolyze the 3'-phospho-tyrosyl that in the cell covalently links DNA Topoisomerase I (Topo1) and DNA.
Nuclear translocation of heparan sulfate proteoglycans and their functional significance.
Dobra et al., Budapest, Hungary. In Biochim Biophys Acta, 2014
Evidence point to possible functions in hampering cell proliferation, inhibition of DNA topoisomerase I activity and inhibition of gene transcription.
Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms.
Klein et al., New York City, United States. In Nature, 2014
In cells lacking RNase H2, Srs2 unwinds DNA from the 5' side of a nick generated by DNA topoisomerase I at a ribonucleoside monophosphate residue.
Topoisomerases facilitate transcription of long genes linked to autism.
Zylka et al., Chapel Hill, United States. In Nature, 2013
Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expression of extremely long genes in mouse and human neurons, including nearly all genes that are longer than 200 kilobases.
ERCC1 and topoisomerase I expression in small cell lung cancer: prognostic and predictive implications.
De Castro Carpeño et al., Madrid, Spain. In Int J Oncol, 2012
In survival analyses, a significant correlation between a better progression free survival with a low TOP I RNA expression as well as a negative ERCC1 inmunostaining were found.
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.
Pommier et al., Kyoto, Japan. In J Biol Chem, 2012
Our results show that Tdp1 and CtIP act in parallel pathways for the repair of Top1cc and MMS-induced lesions but are epistatic for Top2cc.
Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.
Kaufmann et al., Rochester, United States. In J Biol Chem, 2012
model in which small molecule inhibitors convert PARP1 into a protein that potentiates the effects of topoisomerase I poisons by binding to damaged DNA and preventing its normal repair.
TOP1 gene copy numbers in colorectal cancer samples and cell lines and their association to in vitro drug sensitivity.
Brünner et al., Frederiksberg, Denmark. In Scand J Gastroenterol, 2012
Clinical samples demonstrated increased TOP1 gene copy number and increased TOP1/chromosome 20 centromere ratio.
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.
Honjo et al., Kyoto, Japan. In Proc Natl Acad Sci U S A, 2011
Activation-induced cytidine deaminase -induced decrease in Top1 is critical for somatic hypermutation.
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.
Gilson et al., Shanghai, China. In Cell, 2010
Genetic data indicate that DNA topoisomerase 2alpha acts in the same pathway of telomere protection as TRF2 and Apollo.
Antitumour drugs impede DNA uncoiling by topoisomerase I.
Dekker et al., Delft, Netherlands. In Nature, 2007
Camptothecins, such as topotecan, induce cell death by poisoning DNA topoisomerase I, an enzyme capable of removing DNA supercoils.
share on facebooktweetadd +1mail to friends