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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Polymerase , alpha 1, catalytic subunit

DNA polymerase alpha
Top mentioned proteins: POLYMERASE, CAN, HAD, ACID, PCNA
Papers on DNA polymerase alpha
Feasibility and acceptance of cervicovaginal self-sampling within the German National Cohort (Pretest 2).
Kaufmann et al., Braunschweig, Germany. In Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2014
Human beta-globin and DNA polymerase alpha (PolA) sequences were used as positive controls for the detection of human DNA during HPV detection and STIP, respectively.
Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.
Robbins et al., Israel. In Clin Cancer Res, 2014
In contrast, screening of tandem minigene libraries encoding tumor-specific mutations resulted in the identification of mutated kinesin family member 2C (KIF2C) antigen as a target of TIL 2359, and mutated DNA polymerase alpha subunit B (POLA2) antigen as a target of TIL 2591.
Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients.
Tong et al., In Bmc Genomics, 2013
The single nucleotide polymorphism (SNP) causes DNA polymerase alpha subunit B to localize in the cytoplasm instead of the nucleus.
Why are there so many diverse replication machineries?
Forterre, Orsay, France. In J Mol Biol, 2013
A major puzzle is the presence in eukaryotes of the unfaithful DNA polymerase alpha (Pol α) to prime Okazaki fragments.
In vitro antifungal activity of synthetic dsRNA molecules against two pathogens of banana, Fusarium oxysporum f. sp. cubense and Mycosphaerella fijiensis.
Bailey et al., Kampala, Uganda. In Pest Manag Sci, 2013
CONCLUSION: The dsRNAs for adenylate cyclase, DNA polymerase alpha subunit and DNA polymerase delta subunit showed high levels of spore germination inhibition during both self- and cross-species tests, making them the most promising targets for RNA-mediated resistance in banana against these fungal pathogens.
The role of DNA polymerase alpha in the control of mutagenesis in Saccharomyces cerevisiae cells starved for nutrients.
Pavlov et al., Omaha, United States. In Journal 2093-4947, 2010
In nature, micro organisms experience numerous environmental stresses and generally grow poorly most of the time.
TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: implications for a replication restart-based mechanism for ATR checkpoint activation.
Michael et al., Cambridge, United States. In Cell Cycle, 2009
We review recent studies showing that TopBP1 controls the loading of 9-1-1 onto stalled replication forks via a pathway that also requires DNA polymerase alpha (pol alpha).
TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.
Michael et al., Cambridge, United States. In J Cell Biol, 2009
TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.
Sulfo-quinovosyl-acyl-glycerol (SQAG), a eukaryotic DNA polymerase inhibitor and anti-cancer agent.
Sakaguchi et al., Kōbe, Japan. In Curr Med Chem Anticancer Agents, 2005
It was found that a class of sulfolipids known as sulfo-quinovosyl-acyl-glycerols (SQAGs) from ferns and algae are potent inhibitors of eukaryotic DNA polymerase alpha and beta and effective anti-neoplastic agents.
Nucleocytoplasmic lectins.
Patterson et al., East Lansing, United States. In Biochim Biophys Acta, 2004
This localization is consistent with the findings that annexin A1 possesses unwinding and annealing activities of a helicase and that annexin A2 is associated with a primer recognition complex that enhances the activity of DNA polymerase alpha.
Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage.
Diffley et al., London, United Kingdom. In Philos Trans R Soc Lond B Biol Sci, 2004
We have examined the role of different cyclins in the phosphorylation and regulation of several replication/regulatory factors including Cdc6, Sic1, ORC and DNA polymerase alpha-primase.
Structure of the replicating complex of a pol alpha family DNA polymerase.
Steitz et al., New Haven, United States. In Cell, 2001
This ternary complex structure in the human DNA polymerase alpha family shows a 60 degrees rotation of the fingers domain relative to the apo-protein structure, similar to the fingers movement in pol I family polymerases.
DNA primases.
Richardson et al., Valhalla, United States. In Annu Rev Biochem, 2000
The second major primase class comprises heterodimeric eukaryotic primases that form a complex with DNA polymerase alpha and its accessory B subunit.
Activation of the DNA replication checkpoint through RNA synthesis by primase.
Newport et al., San Diego, United States. In Science, 2000
Chromatin was competent to initiate a checkpoint response only after the DNA was unwound and DNA polymerase alpha had been loaded.
Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases.
Haber et al., Waltham, United States. In Cell, 1999
Surprisingly, mutants of lagging strand replication, DNA polymerase alpha (pol1-17), DNA primase (pri2-1), and Rad27p (rad27 delta) also greatly inhibit completion of DSB repair, even in G1-arrested cells.
Herpes simplex virus DNA replication.
Lehman et al., Newark, United States. In Annu Rev Biochem, 1996
Host enzymes, notably DNA polymerase alpha-primase, DNA ligase I, and topoisomerase II, are probably also required.
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