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Major histocompatibility complex, class II, DM beta

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MHC, CAN, ACID, HAD, HLA-DMA
Papers on DMB
4,7-Dimethoxy-5-methyl-1,3-benzodioxole from Antrodia camphorata inhibits LPS-induced inflammation via suppression of NF-κB and induction HO-1 in RAW264.7 cells.
Huang et al., Taiwan. In Int Immunopharmacol, Jan 2016
In this study, we investigated the anti-inflammatory potential of 4,7-dimethoxy-5-methyl-1,3-benzodioxole (DMB), one of the major benzenoid compounds isolated from the mycelia of A. camphorata.
Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis.
Hazen et al., Cleveland, United States. In Cell, Jan 2016
A structural analog of choline, 3,3-dimethyl-1-butanol (DMB), is shown to non-lethally inhibit TMA formation from cultured microbes, to inhibit distinct microbial TMA lyases, and to both inhibit TMA production from physiologic polymicrobial cultures (e.g., intestinal contents, human feces) and reduce TMAO levels in mice fed a high-choline or L-carnitine diet.
Large-Scale Glycomics of Livestock: Discovery of Highly Sensitive Serum Biomarkers Indicating an Environmental Stress Affecting Immune Responses and Productivity of Holstein Dairy Cows.
Nishimura et al., Sapporo, Japan. In J Agric Food Chem, Jan 2016
Glycoblotting combined with MALDI-TOF/MS and DMB/HPLC allowed for comprehensive glycomics of whole serum glycoproteins.
Gorlin syndrome and desmoplastic medulloblastoma: Report of 3 cases with unfavorable clinical course and novel mutations.
Neuberg et al., Charleston, United States. In Pediatr Blood Cancer, Oct 2015
We present three cases of genetically confirmed Gorlin syndrome with desmoplastic medulloblastoma (DMB) in whom tumor recurred despite standard therapy.
Anaerobic biosynthesis of the lower ligand of vitamin B12.
Taga et al., Berkeley, United States. In Proc Natl Acad Sci U S A, Sep 2015
The complete aerobic and anaerobic pathways for the de novo biosynthesis of B12 are known, with the exception of the steps leading to the anaerobic biosynthesis of the lower ligand, 5,6-dimethylbenzimidazole (DMB).
A Multiplex Assay for the Diagnosis of Mucopolysaccharidoses and Mucolipidoses.
van Vlies et al., Amsterdam, Netherlands. In Plos One, 2014
Often the dimethylmethylene blue dye-binding (DMB) assay is used, although false-negative results have been reported.
Human macrophages and monocytes express functional Na(+)/Ca (2+) exchangers 1 and 3.
Marone et al., Napoli, Italy. In Adv Exp Med Biol, 2012
This response was completely abolished by the NCX inhibitor 5-(N-4-chlorobenzyl)-20,40-dimethylbenzamil (CB-DMB).
Analysis of HLA-DM polymorphisms in the Chinese Han population.
Liu et al., Shanghai, China. In Tissue Antigens, 2012
DMA*01:01 (69.35%) and DMB*01:01 (52.5%) alleles were more frequent in Chinese Hans
Forced expression of HLA-DM at the surface of dendritic cells increases loading of synthetic peptides on MHC class II molecules and modulates T cell responses.
Thibodeau et al., Montréal, Canada. In J Immunol, 2011
Overexpression of HLA-DM at the plasma membrane of dendritic cells improves quantitatively, but also qualitatively, the presentation of CD4-expressing T cell epitopes in cellular vaccine therapies for cancer.
DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.
Mellins et al., Stanford, United States. In Immunology, 2010
Multiple mechanisms, operating along the biosynthetic pathway of class II molecules, contribute to DM-mediated increases in the abundance of low-CLIP-affinity alleles.
Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond.
Gorski et al., Milwaukee, United States. In J Immunol, 2010
HLA-DM mediates a noncooperative release of prebound influenza virus hemagglutinin peptides from wild-type HLA-DR1 by destabilizing the beta81 hydrogen (H-)bond, since a similar phenomenon is observed when this H-bond is absent.
Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes.
Jensen et al., Salt Lake City, United States. In J Immunol, 2009
No individual component of conserved HLA-DM hydrogen bond network demonstrates an essential role in the DM catalytic mechanism. Catalytic potency of HLA-DM with each beta-chain mutant was equal to or greater than that observed with wild-type HLA-DR1.
BluB cannibalizes flavin to form the lower ligand of vitamin B12.
Walker et al., Cambridge, United States. In Nature, 2007
The biosynthesis of the lower ligand of vitamin B(12), 5,6-dimethylbenzimidazole (DMB), is poorly understood.
'Ovar-Mhc' - ovine major histocompatibility complex: structure and gene polymorphisms.
Murray et al., Palmerston North, New Zealand. In Genet Mol Res, 2005
The class II region is better characterised, with evidence of one DRA, four DRB (one coding and three non-coding), one DQA1, two DQA2, and one each of the DQB1, DQB2, DNA, DOB, DYA, DYB, DMA, and DMB genes in the region.
Partial reactions of the Na,K-ATPase: kinetic analysis and transport properties.
Sokolov et al., Konstanz, Germany. In Acta Physiol Scand Suppl, 1998
Current transients produced by the Na,K-ATPase could be induced by ATP-concentration jumps using DMB-caged ATP.
Genetic influences on sarcoidosis.
Ohno et al., Yokohama, Japan. In Eye (lond), 1996
We screened the TNFA, TNFB, HSP70-1 and Hum70t genes around the class III region, as well as the HLA-DMA and -DMB genes in the class II region, for genetic polymorphism in sarcoidosis.
Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments.
Trowsdale et al., London, United Kingdom. In Science, 1995
DMA and DMB associated and accumulated in multilaminar, intracellular compartments with classical class II molecules, but were found infrequently, if at all, at the cell surface.
Antigen presentation. Getting peptides into MHC class II molecules.
Cresswell, New Haven, United States. In Curr Biol, 1994
The long search for MHC-linked genes known to be required for antigen processing has turned up HLA-DMA and HLA-DMB, genes that seem to encode a dimer similar to the MHC class II molecule.
HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.
Pious et al., Seattle, United States. In Nature, 1994
contains a mutation in HLA-DMB; and (2) transfection and expression of DMA complementary DNA in 2.2.93, and DMB cDNA in 9.5.3,
An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules.
Mellins et al., Philadelphia, United States. In Nature, 1994
Here we report that multiple independent mutants with the class II presentation defect harbour lesions in HLA-DMB, an MHC-linked gene encoding a class II-like beta-chain.
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