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Distal-less homeobox 6

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Dlx5, DSS1, CAN, delta4, CIs
Papers on Dlx6
Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors.
Carén et al., Göteborg, Sweden. In Epigenetics, Feb 2016
The genes with the highest number of hypermethylated CpG sites in INRG M tumors are TERT, PCDHGA4, DLX5, and DLX6-AS1.
Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis.
Levi et al., Paris, France. In Hum Mol Genet, Feb 2016
Dlx5 and Dlx6 are two closely associated homeobox genes which code for transcription factors involved in the control of steroidogenesis and reproduction.
The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand.
Merlo et al., Torino, Italy. In Hum Mol Genet, Jan 2016
Type-1 SHFM is linked to deletions/rearrangements of the DLX5-DLX6 locus and point mutations in the DLX5 gene.
Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population.
Saxena et al., New Delhi, India. In Omics, Nov 2015
These included four genes (PTK2, RND1, RND3, and UBL3) with promoter hypermethylation and downregulation, and 19 genes (SEMG2, CD97, CTNND2, CADM3, OMD, NEFM, FBN2, CTNNB1, DLX6, UGT2B4, CCDC80, PZP, SERPINA4, TNFSF13B, NPC1, COL1A1, TAC3, BMP8A, and IL22RA2) with promoter hypomethylation and upregulation.
DLX4 is associated with orofacial clefting and abnormal jaw development.
Slavotinek et al., San Francisco, United States. In Hum Mol Genet, Sep 2015
In mammals, there are three Dlx homeobox clusters with closely located gene pairs (Dlx1/Dlx2, Dlx3/Dlx4, Dlx5/Dlx6).
7q21.3 Deletion involving enhancer sequences within the gene DYNC1I1 presents with intellectual disability and split hand-split foot malformation with decreased penetrance.
Velinov et al., New York City, United States. In Mol Cytogenet, 2014
Genes considered to be associated with SHFM1 are DLX5 and DLX6.
Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.
Shotelersuk et al., Bangkok, Thailand. In J Med Genet, 2014
While double knockout of Dlx5 and Dlx6 resulted in limb defects in mice, the majority of patients with SHFM1 had only heterozygous chromosomal abnormalities.
Expression of long non-coding RNA DLX6-AS1 in lung adenocarcinoma.
Zhang et al., Zhengzhou, China. In Cancer Cell Int, 2014
qRT-PCR and Western blotting were used to verify that down-regulation lncRNA DLX6-AS1 decreased DLX6 (distal-less homeobox 6) mRNA and protein expression.
Heterozygous DLX5 nonsense mutation associated with isolated split-hand/foot malformation with reduced penetrance and variable expressivity in two unrelated families.
Jamsheer et al., Poznań, Poland. In Birth Defects Res A Clin Mol Teratol, 2014
In most cases, SHFM1 results from heterozygous deletions encompassing DLX5/DLX6 genes or from inversions and translocations separating the genes from their limb specific enhancers.
DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations.
Guerrini et al., Milano, Italy. In Hum Mol Genet, 2014
The p63 and the DLX5;DLX6 transcription factors, expressed in the embryonic limb buds and ectoderm, are disease genes for these conditions.
Next generation sequencing of chromosomal rearrangements in patients with split-hand/split-foot malformation provides evidence for DYNC1I1 exonic enhancers of DLX5/6 expression in humans.
Ellard et al., Exeter, United Kingdom. In J Med Genet, 2014
This separates the DYNC1I1 exons recently identified as limb enhancers in mouse studies from their target genes, DLX5 and DLX6.
A LINE-1 insertion in DLX6 is responsible for cleft palate and mandibular abnormalities in a canine model of Pierre Robin sequence.
Bannasch et al., Chengdu, China. In Plos Genet, 2014
Sequencing of two regional candidate homeobox genes in NSDTRs, distal-less homeobox 5 (DLX5) and distal-less homeobox 6 (DLX6), identified a 2.1 kb LINE-1 insertion within DLX6 in CP1 NSDTRs.
Rapp-Hodgkin syndrome and SHFM1 patients: delineating the p63-Dlx5/Dlx6 pathway.
López-Expósito et al., Murcia, Spain. In Gene, 2012
Two patients that have in common a p63-Dlx5/Dlx6 pathway dysregulation.
Activity of dlx5a/dlx6a regulatory elements during zebrafish GABAergic neuron development.
Ekker et al., Ottawa, Canada. In Int J Dev Neurosci, 2011
Data suggest that zebrafish dlx5a/dlx6a intergenic cis-regulatory elements may be involved in a conserved genetic pathway necessary for proper dlx expression during zebrafish GABAergic neuron development.
Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala.
Rubenstein et al., San Francisco, United States. In J Comp Neurol, 2011
Data suggets that RNA expression array analysis of the E18.5 striatum is useful in identifying the transcription factors that are expressed in this tissue, but did not identify major changes in gene expression in the Dlx6(LacZ/LacZ) mutant.
Allelic reduction of Dlx5 and Dlx6 results in early follicular depletion: a new mouse model of primary ovarian insufficiency.
Levi et al., Paris, France. In Hum Mol Genet, 2011
allelic reduction of Dlx5 and Dlx6 in the mouse results in a POI-like phenotype, characterized by reduced fertility and early follicular exhaustion.
Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis.
Clouthier et al., Aurora, United States. In Development, 2011
Hand2 plays key role in lower jaw patterning in part by establishing negative-feedback loop in which Hand2 represses Dlx5 and Dlx6 expression in distal arch ectomesenchyme following Dlx5- and Dlx6-mediated induction of Hand2 expression in the same region
Jaw development: chinless wonders.
Graham, London, United Kingdom. In Curr Biol, 2003
Recently, clear evidence of this has emerged from Dlx-5; Dlx-6 double mutants, in which the lower jaw is transformed to an upper jaw.
Are there CAG repeat expansion-related disorders outside the central nervous system?
Pfeffer et al., Genova, Italy. In Brain Res Bull, 2001
We have identified a poly-glutamine/poly-proline repeat in the homeobox gene DLX6.
Multiple functions of Dlx genes.
Levi et al., Genova, Italy. In Int J Dev Biol, 1999
In addition, Dlx5 and Dlx6 are expressed in differentiating osteoblasts.
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