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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Death-associated protein kinase 3

calmodulin (CaM)-regulated protein kinase; may be involved in apoptosis and neuronal development [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, V1a, JNK, ACID, AP-1
Papers using DLK antibodies
A role for mixed lineage kinases in regulating transcription factor CCAAT/enhancer-binding protein-{beta}-dependent gene expression in response to interferon-{gamma}.
Bridger Joanna Mary, In PLoS ONE, 2004
... The rabbit polyclonal antibody raised against DLK was obtained from Abgent (San Diego, CA, USA) ...
Papers on DLK
Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.
Oetjen et al., Göttingen, Germany. In Cell Signal, Feb 2016
UNASSIGNED: The dual leucine zipper kinase DLK induces β-cell apoptosis by inhibiting the transcriptional activity conferred by the β-cell protective transcription factor cAMP response element binding protein CREB.
A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle.
Walsh et al., Calgary, Canada. In Mol Pharmacol, Jan 2016
A novel inhibitor of zipper-interacting protein kinase (ZIPK) was used to examine the involvement of ZIPK in the regulation of smooth muscle contraction.
Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation.
Deshmukh et al., Chapel Hill, United States. In Cell Host Microbe, Jan 2016
This JNK activation in neurons is mediated by dual leucine zipper kinase (DLK) and JNK-interacting protein 3 (JIP3), which direct JNK toward stress responses instead of other cellular functions.
DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans.
Jansen et al., Rotterdam, Netherlands. In Plos Genet, Dec 2015
Mutation of two other components of this pathway, dual leucine zipper-bearing MAPKKK DLK-1 and p38 MAPK PMK-3, also suppress the gpa-3QL short cilium phenotype.
The effect of fibroblast growth factor on distinct differentiation potential of cord blood-derived unrestricted somatic stem cells and Wharton's jelly-derived mesenchymal stem/stromal cells.
Park et al., Inch'ŏn, South Korea. In Cytotherapy, Dec 2015
RESULTS: Overall, CB-USSCs expressed DLK-1 and negative for all the HOX gene markers.
Death-associated protein kinase 2: Regulator of apoptosis, autophagy and inflammation.
Geering, Basel, Switzerland. In Int J Biochem Cell Biol, Aug 2015
The three most conserved family members DAPK1/DAPK, DAPK2 and DAPK3/ZIPK share a high degree of homology in their catalytic domain, but differ significantly in their extra-catalytic structures and tissue-expression profiles.
Comprehensive transcriptional landscape of aging mouse liver.
Vijg et al., United States. In Bmc Genomics, 2014
Interestingly, multiple lncRNAs (Meg3, Rian, Mirg) from the Dlk-Dio3 microRNA locus were found up-regulated in aging liver, classifying this locus as a putative regulatory hotspot locus in aging liver.
The DAPK family: a structure-function analysis.
Kimchi et al., Israel. In Apoptosis, 2014
The family includes DRP-1 and ZIP-kinase (ZIPK), both of which share significant homology within the common N-terminal kinase domain, but differ in their extra-catalytic domains.
Zipper interacting protein kinase (ZIPK): function and signaling.
Yamawaki et al., Aomori, Japan. In Apoptosis, 2014
Zipper interacting protein kinase (ZIPK), also known as death associated protein kinase 3, is a serine/threonine kinase that mediates variety of cell functions.
Involvement of myosin regulatory light chain diphosphorylation in sustained vasoconstriction under pathophysiological conditions.
Walsh et al., Asahikawa, Japan. In J Smooth Muscle Res, 2013
Ca(2+)-independent contraction can be induced by inhibition of myosin light chain phosphatase, which correlates with diphosphorylation of LC20 at Ser19 and Thr18, catalysed by integrin-linked kinase (ILK) and zipper-interacting protein kinase (ZIPK).
Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions.
Welsbie et al., Baltimore, United States. In Future Med Chem, 2013
Dual leucine zipper kinase (DLK) is a serine/threonine protein kinase that is a member of the mixed lineage kinase subfamily.
Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration.
DiAntonio et al., Saint Louis, United States. In Neuron, 2012
These data demonstrate that DLK enhances regeneration by promoting a retrograde injury signal that is required for the activation of the neuronal proregenerative program.
Decreased myosin phosphatase target subunit 1(MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle.
Uray et al., Houston, United States. In Neurogastroenterol Motil, 2012
Data suggest that intestinal edema inhibits MLC phosphorylation by decreasing inhibitory phosphorylation of MYPT1 via decreased ROCK and ZIPK activities, resulting in more MLC phosphatase activity.
Chemical genetics of zipper-interacting protein kinase reveal myosin light chain as a bona fide substrate in permeabilized arterial smooth muscle.
MacDonald et al., Calgary, Canada. In J Biol Chem, 2011
ZIPK is involved in the regulation of smooth muscle contraction through direct phosphorylation of LC(20).
Loss of DLK expression in WI-38 human diploid fibroblasts induces a senescent-like proliferation arrest.
Blouin et al., Sherbrooke, Canada. In Biochem Biophys Res Commun, 2011
these findings indicate that DLK participates in cell proliferation and/or survival, at least in part, by modulating the expression of cell cycle regulatory proteins.
DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity.
Lewcock et al., San Francisco, United States. In J Cell Biol, 2011
The mixed lineage kinase dual leucine zipper kinase (DLK) selectively regulates the JNK-based stress response pathway to mediate axon degeneration and neuronal apoptosis without influencing other aspects of JNK signaling.
The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
Jin et al., San Diego, United States. In Cell, 2009
The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously implicated in synaptogenesis and axon outgrowth in C. elegans and other animals.
Axon regeneration requires a conserved MAP kinase pathway.
Bastiani et al., Salt Lake City, United States. In Science, 2009
Here, we show that the DLK-1 mitogen-activated protein (MAP) kinase pathway is essential for regeneration in Caenorhabditis elegans motor neurons.
Heritable transposon silencing initiated by a naturally occurring transposon inverted duplication.
Lisch et al., Berkeley, United States. In Nat Genet, 2005
This locus, Mu killer (Muk), results from the inverted duplication of a partially deleted autonomous MuDR element located at the breakpoint of a genomic deletion.
Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development.
Jin et al., Santa Cruz, United States. In Cell, 2005
We report that RPM-1 negatively regulates a p38 MAP kinase pathway composed of the dual leucine zipper-bearing MAPKKK DLK-1, the MAPKK MKK-4, and the p38 MAP kinase PMK-3.
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