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Ankyrin repeat domain 6

Diversin, ANKRD6, ankyrin repeat domain 6
This gene encodes a protein which is thought to be involved in the Wnt signaling pathway and embryonic axis formation. Similar genes have been found in human, rhesus macaque, and zebrafish. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Frizzled, PKI, JNK, Dvl2, AP-1
Papers on Diversin
Genetic studies of ANKRD6 as a molecular switch between Wnt signaling pathways in human neural tube defects.
Kibar et al., Genova, Italy. In Birth Defects Res A Clin Mol Teratol, 2015
Diversin, encoded by Ankrd6, is an ankyrin repeat protein that activates the non canonical PCP signaling and simultaneously inhibits the canonical pathway.
Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear.
Chen et al., Atlanta, United States. In Dev Biol, 2014
Here we report that the over-expression of the murine Ankrd6 (mAnkrd6) gene that shares homology with Drosophila core PCP gene diego causes a typical PCP phenotype in Drosophila, and mAnkrd6 can rescue the loss of function of diego in Drosophila.
Diversin is overexpressed in human gliomas and its depletion inhibits proliferation and invasion.
Wang et al., Shenyang, China. In Tumour Biol, 2014
Previous study indicated diversin overexpression in human cancers.
Diversin increases the proliferation and invasion ability of non-small-cell lung cancer cells via JNK pathway.
Wang et al., Shenyang, China. In Cancer Lett, 2014
The expression and significance of Diversin in human tumors remains unclear.
Proteomic analysis of the follicular fluid of Tianzhu white yak during diestrus.
Zhang et al., Yinchuan, China. In Int J Mol Sci, 2013
Fourteen of these spots were analyzed by MALDI-TOF/TOF-MS and identified as: AS3MT, VDP, ANKRD6, C10orf107 protein, MRP4, MAPKAP1, AGO3, profilin-β-actin, SPT2 homolog, AGP, AR, RNF20, obscurin-like-1, and one unnamed protein.
Diversin is overexpressed in breast cancer and accelerates cell proliferation and invasion.
Jin et al., Shenyang, China. In Plos One, 2013
Diversin was recently reported to play roles in Wnt and JNK pathways.
Diversin, from Ferula diversivittata protects human lymphocytes against oxidative stress induced by H₂O₂.
Behravan et al., Mashhad, Iran. In Nat Prod Res, 2012
In this study, the antigenotoxic effects of diversin, a prenylated coumarin obtained from Ferula diversivittata roots were evaluated using comet assay.
Variants of the ankyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adults.
Pescatello et al., United States. In J Strength Cond Res, 2012
Ankyrin repeat domain 6 (ANKRD6) is a ubiquitous protein that associates with early development in mammals and is highly expressed in the brain, spinal cord, and heart of humans.
Regulation of basal body and ciliary functions by Diversin.
Sokol et al., New York City, United States. In Mech Dev, 2011
In this study, we assessed a role for Diversin, a putative Wnt pathway mediator, in developmental processes that involve cilia.
Dishevelled is essential for neural connectivity and planar cell polarity in planarians.
Adell et al., Barcelona, Spain. In Proc Natl Acad Sci U S A, 2011
Second, Smed-dvl-2, together with the S. mediterranea homologs of Van-Gogh (Vang) and Diversin (Div), is required for apical positioning of the basal bodies of epithelial cells.
Polarized translocation of fluorescent proteins in Xenopus ectoderm in response to Wnt signaling.
Sokol et al., In J Vis Exp, 2010
In this experimental protocol we describe how subcellular localization of Diversin, a cytoplasmic protein that has been implicated in signaling and cell polarity determination is visualized in Xenopus ectodermal cells to study Wnt signal transduction.
Expression and proliferation-promoting role of Diversin in the neuronally committed precursor cells migrating in the adult mouse brain.
Sawamoto et al., Nagoya, Japan. In Stem Cells, 2010
Results indicate that Diversin plays an important role in the proliferation of neuroblasts in the subventricular zone of the adult brain.
Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.
Berns et al., Amsterdam, Netherlands. In Oncogene, 2010
We find that Frat synergizes with Diversin, the mammalian homolog of the Drosophila PCP protein diego, in the activation of JNK/AP-1 signaling.
Centrosomal localization of Diversin and its relevance to Wnt signaling.
Sokol et al., New York City, United States. In J Cell Sci, 2009
These observations suggest that the centrosomal localization of Diversin is crucial for its function in Wnt signaling.
The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9.
Schäfer et al., Freiburg, Germany. In Biochem Biophys Res Commun, 2009
Diversin, containing several nuclear localization signals, translocates to the nucleus, where it interacts with the transcription factor AF9.
WNT signaling pathway and stem cell signaling network.
Katoh et al., Japan. In Clin Cancer Res, 2007
Microtubule affinity-regulating kinase (PAR-1) family kinases, casein kinase I epsilon (CKI epsilon), and FRAT are positive regulators of the canonical WNT pathway, whereas APC, AXIN1, AXIN2, CKI alpha, NKD1, NKD2, beta TRCP1, beta TRCP2, ANKRD6, Nemo-like kinase (NLK), and peroxisome proliferator-activated receptor gamma (PPAR gamma) are negative regulators.
Diversin regulates heart formation and gastrulation movements in development.
Birchmeier et al., Berlin, Germany. In Proc Natl Acad Sci U S A, 2006
demonstrate that Diversin and Dishevelled function together in a mutually dependent fashion in zebrafish gastrulation and organ formation
WNT/PCP signaling pathway and human cancer (review).
Katoh, Tokyo, Japan. In Oncol Rep, 2005
Human VANGL1, VANGL2 (Van Gogh homologs), CELSR1, CELSR2, CELSR3 (Starry night homologs), DVL1, DVL2, DVL3 (Dishevelled homologs), PRICKLE1, PRICKLE2 (Prickle homologs), and ANKRD6 (Diego homolog) are core PCP signaling molecules.
Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development.
Lambert De Rouvroit et al., Brussels, Belgium. In Dev Dyn, 2002
These data suggest that ankyrin repeat domain 6 (Ankrd6) may be involved in brain development in interaction not only with Celsr/Flamingo but also with other signaling pathways.
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