New targets for the antitumor activity of gambogic acid in hematologic malignancies.
Wuhan, China. In Acta Pharmacol Sin, 2013
These include the regulation of expression and intracellular positioning of nucleoporin and nucleophosmin; downregulation of steroid receptor coactivator-3 (SRC-3) and its downstream proteins; upregulation of death inducer-obliterator (DIO-1); downregulation of HERG potassium channel; as well as induction of reactive oxygen species (ROS) accumulation.
Osteoblast apoptosis and bone turnover.
Indianapolis, United States. In J Bone Miner Res, 2001
In reviewing selected work on interdigital apoptosis in the developing skeleton, we discuss the putative roles of the bone morphogenetic proteins (BMPs), Msx2, RAR-gamma, and death inducer obliterator 1 (DIO-1).