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Ring finger protein 2

Ding, ring-2, Ring1B, RNF2
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Polycomb, CAN, Histone, PRC1, H2A
Papers using Ding antibodies
Expression and imaging of fluorescent proteins in the C. elegans gonad and early embryo
Sherwood David R. et al., In Nature cell biology, 2007
... DingMThe cell signaling adaptor protein EPS-8 is ...
Obese Mice Lacking Inducible Nitric Oxide Synthase Are Sensitized to the Metabolic Actions of Peroxisome Proliferator–Activated Receptor-γ Agonism
Marette André et al., In Diabetes, 2005
... AH, Lin Y, Jelicks LA, Laplante M, Nawrocki AR, Rajala MW, Parlow AF, Cheeseboro L, Ding YY, Russell RG, Lindemann D, Hartley A, Baker GR, Obici S, Deshaies Y, Ludgate M, Rossetti L, Scherer PE: A transgenic mouse with a deletion in ...
Distinctive omorphology of hippocampal CA1 terminations in orbital and medial frontal cortex in macaque monkeys.
Rockland Kathleen S. et al., In Frontiers in Neuroanatomy, 2005
... ; Ding et al., 2000; Rockland and Ojima, ...
Core transcriptional regulatory circuitry in human embryonic stem cells.
Cordes Nils, In PLoS ONE, 2004
... Antibodies for Western blotting and immunofluoresence included anti-Bmi1 (Upstate; Lake Placid, NY), anti-Ring1B (MBL; Woburn, MA), anti-YY1 (Santa ...
Cellular roles of DNA topoisomerases: a molecular perspective.
Bielinsky Anja-Katrin, In PLoS ONE, 2001
... Antibody for Ring1B was purchased from MBL International (Woburn, MA) ...
Papers on Ding
Chronic Normobaric Hypoxia Induces Pulmonary Hypertension in Rats: Role of NF-κB.
Gong et al., Wenzhou, China. In High Alt Med Biol, Feb 2016
UNASSIGNED: Junming Fan, Xiaofang Fan, Yang Li, Lu Ding, Qingqing Zheng, Jinbin Guo, Dongmei Xia, Feng Xue, Yongyu Wang, Shufang Liu, and Yongsheng Gong.
MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
Dobbelstein et al., Göttingen, Germany. In Mol Cell, Feb 2016
Removing MDM2 simultaneously with the H2AK119 E3 ligase Ring1B/RNF2 further induced these genes and synthetically arrested cell proliferation.
Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of H3K27 Deacetylation and Methylation.
Xue et al., United States. In J Biol Chem, Feb 2016
This is followed by dissociation of the polycomb repressive complexes, including the H3K27 methyltransferase enhancer of zeste homologue (EZH2), suppressor of zeste 12 (SUZ12), and ring finger protein 2 (RNF2) from, and concomitant recruitment of H3K27 demethylase ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) to UCP1 and PGC1α promoters, leading to decreased H3K27 trimethylation, a histone transcriptional repression mark.
Role of Polycomb RYBP in Maintaining the B-1 to B-2 B-Cell Lineage Switch in Adult Hematopoiesis.
Vidal et al., Madrid, Spain. In Mol Cell Biol, Jan 2016
We have studied the hematopoietic activity of RYBP, a direct interactor and proposed modulator of RING1A/RING1B-dependent histone H2A monoubiquitylation (H2AUb).
Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells.
Kleeff et al., München, Germany. In Oncotarget, Jan 2016
Here, we analyzed whether elevated levels of the polycomb repressor complex 1 (PRC1) components Bmi1 and Ring1b and their catalyzed histone modification H2AK119ub in ADMs and tumor cells, are responsible for the mediation of acinar gene silencing.
Folate-Dependent Purine Nucleotide Biosynthesis in Humans.
Tamura et al., Birmingham, United States. In Adv Nutr, Sep 2015
Both transformylases utilize 10-formyltetrahydrofolate (10-formyl-H4folate), where the formyl-carbon sources include ring-2-C of histidine, 3-C of serine, 2-C of glycine, and formate.
Tex10: A New Player in the Core Pluripotency Circuitry.
Buganim, Jerusalem, Israel. In Cell Stem Cell, Jul 2015
In this issue of Cell Stem Cell, Ding et al. (2015) identify a new Sox2-interacting protein, Tex10, which, together with Tet1 and p300, regulate super-enhancers to sustain pluripotency.
TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.
Green et al., Worcester, United States. In Nature, 2015
We find that in human breast cancer cell lines containing amplified 17q23, TRIM37 is upregulated and, reciprocally, the major H2A ubiquitin ligase RNF2 (also known as RING1B) is downregulated.
A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response.
Tang et al., Hamilton, Canada. In Biomolecules, 2014
Mechanistically, BMI1 is a subunit of the Polycomb repressive complex 1 (PRC1), and binds the catalytic RING2/RING1b subunit to form a functional E3 ubiquitin ligase.
Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome.
Tan et al., United States. In Nature, 2014
This group includes the Polycomb repressive complex 1 (PRC1), which ubiquitylates nucleosomal histone H2A Lys 119 using its E3 ubiquitin ligase subunits, Ring1B and Bmi1, together with an E2 ubiquitin-conjugating enzyme, UbcH5c.
The DING family of phosphate binding proteins in inflammatory diseases.
Chabrière et al., Marseille, France. In Adv Exp Med Biol, 2013
Belonging to the DING protein, a sub-family of phosphate binding proteins (PBP or pstS), HPBP stabilizes hPON-1 and might prevent calcification of arteries in case of advance atherosclerosis.
DING proteins: numerous functions, elusive genes, a potential for health.
Bernier, Strasbourg, France. In Cell Mol Life Sci, 2013
However, DING protein genes are conspicuously absent from databases.
This niche is a maze; an amazing niche.
Frenette et al., United States. In Cell Stem Cell, 2013
Two recent studies in Nature (Ding and Morrison, 2013; Greenbaum et al., 2013) have shed light into the bone marrow stromal subsets making CXCL12, a chemokine critical for HSC maintenance.
PRC1 coordinates timing of sexual differentiation of female primordial germ cells.
Peters et al., Basel, Switzerland. In Nature, 2013
Here we identify gene-dosage-dependent roles in PGC development for Ring1 and Rnf2, two central components of the Polycomb repressive complex 1 (PRC1).
Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors.
Sharpe et al., London, United Kingdom. In Dev Biol, 2012
loss of Ring1a/b postnatally results in defective cervical loops and disturbances of enamel and dentin formation in continuously growing incisors
The level of DING proteins is increased in HIV-infected patients: in vitro and in vivo studies.
Chabriere et al., Marseille, France. In Plos One, 2011
The organism reacts to HIV-infection by an overexpression of DING proteins.
PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.
Eskeland et al., Edinburgh, United Kingdom. In Plos One, 2011
It was shown that Ring1B interacted with multiple complexes in embryonic stem cells. Although H2A.Z co-localized with Eed, Ring1B and CpG islands in chromatin, H2A.Z still blanketed polycomb target loci in the absence of Suz12, Eed, or Ring1B.
Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
Cochran et al., San Francisco, United States. In Embo J, 2011
Crystallography of a complex of the Bmi1/Ring1b RING-RING heterodimer & UbcH5c shows that UbcH5c interacts with Ring1b only. Bmi1/Ring1b interacts with nucleosomal DNA & an acidic patch on histone H4 to achieve specific monoubiquitination of H2A.
Identification and characterization of RNF2 response elements in human kidney cells.
Kang et al., Seoul, South Korea. In Mol Cells, 2011
identification of genes regulated by ring finger protein 2
Mechanisms of adiponectin regulation and use as a pharmacological target.
Kung et al., San Diego, United States. In Curr Opin Pharmacol, 2010
Increased circulating levels of adiponectin are associated with improvement in the metabolic syndrome and reductions are strongly predictive of diabetes risk (Li S, Shin HJ, Ding EL, van Dam RM: Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis.
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