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Arginine vasopressin receptor 2

DiI, ND1, V2R
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ND4, V1a, ND5
Papers using DiI antibodies
Direct conversion of human fibroblasts to multilineage blood progenitors.
Bonini Marcelo G., In PLoS ONE, 2009
... Cells in 4-well slides were co-incubated with DiI-acLDL (Biomedical Technologies) for 1 hour, stained ...
Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation.
Phillips Meg, In PLoS Pathogens, 2006
... (i) Baculovirus insect cell expression: A synthetic codon-optimized gene encoding DI and DII of PfAMA1 3D7 [27] (residues 104–438; numbering based on the initiation methionine, PF11_0344) (GenScript) was subcloned into a modified ...
Mutational Analysis of the Fractalkine Chemokine Domain
Dai Yalei et al., In Lipids in Health and Disease, 2000
... DiI-oxLDL was obtained from Kalen Biomedical (USA) ...
Health criteria and other supporting information.
Cotterill Sue, In PLoS ONE, 1995
... For the long-term experiment, a subgroup of cells was marked with a fluorescent (DiI) dye (Life Technologies Japan, Tokyo, Japan) at ...
Sequence analysis and neuronal expression of fasciclin I in grasshopper and Drosophila
Geßner Reinhard et al., In The Journal of Cell Biology, 1987
... The vital fluorescence membrane dye DiI (1,1′-Dioctadecyl3,3,3′,3′-tetramethylindocarbocyanine perchlorate) was from Becton Dickinson (Heidelberg, FRG) ...
Papers on DiI
Tolvaptan Prolongs Blockage of the Vasopressin Type II Receptor Over 24 Hours in Responders With Stage D Heart Failure.
Komuro et al., Tokyo, Japan. In Int Heart J, Feb 2016
The urine aquaporin-2 (U-AQP2) level relative to the plasma arginine vasopressin (P-AVP) level is a novel predictor of the responsiveness to the vasopressin type 2 receptor (V2R) antagonist tolvaptan (TLV).
5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists.
Schnellmann et al., United States. In J Pharmacol Exp Ther, Feb 2016
Additionally, CP-809,101 and SB-242,084 increased mRNA expression of PGC-1α and the mitochondrial proteins ND1 and NDUFB8 in mice.
Chronic Arsenic Exposure-Induced Oxidative Stress is Mediated by Decreased Mitochondrial Biogenesis in Rat Liver.
Kumar et al., Rohtak, India. In Biol Trace Elem Res, Feb 2016
The messenger RNA (mRNA) expression of mitochondrial and nuclear-encoded subunits of complexes I (ND1 and ND2) and IV (COX I and COX IV) was downregulated in arsenic-treated rats only.
DNA sequence analysis suggests that cytb-nd1 PCR-RFLP may not be applicable to sandfly species identification throughout the Mediterranean region.
Cruz et al., Madrid, Spain. In Parasitol Res, Feb 2016
Thus, it has been recently proposed that the amplification of a DNA region encompassing partially both the cytochrome-B (cytb) and the NADH dehydrogenase 1 (nd1) genes followed by RFLP analysis with the restriction enzyme Ase I allows the rapid identification of the most prevalent species of phlebotomine sandflies in the Mediterranean region.
HepG2 cells biospecific extraction and HPLC-ESI-MS analysis for screening potential antiatherosclerotic active components in Bupeuri radix.
Wang et al., Guangzhou, China. In J Pharm Biomed Anal, Feb 2016
Then SSb2 was used to assess the uptake of DiI-high density lipoprotein (HDL) in HepG2 cells for antiatherosclerotic activity.
Arginine vasopressin receptor signaling and functional outcomes in heart failure.
Tilley et al., Philadelphia, United States. In Cell Signal, Aug 2015
AVP is released from the hypothalamus in response to changes in plasma osmolality and pressure, acting at three distinct G protein-coupled receptors: V1AR, V1BR and V2R.
A Minireview on Vasopressin-regulated Aquaporin-2 in Kidney Collecting Duct Cells.
Kwon et al., Taegu, South Korea. In Electrolyte Blood Press, Jun 2015
Water reabsorption in the collecting duct cells is regulated by arginine vasopressin (AVP) via the vasopressin V2-receptor (V2R).
From sexual attraction to maternal aggression: when pheromones change their behavioural significance.
Martínez-Garcia et al., Burjassot, Spain. In Horm Behav, Feb 2015
There is evidence indicating that ESP1 and MUPs are detected by vomeronasal type 2 receptors (V2R).
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Strippoli et al., Reggio di Calabria, Italy. In Cochrane Database Syst Rev, 2014
MAIN RESULTS: We included 30 studies (2039 participants) that investigated 11 pharmacological interventions (angiotensin-converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARBs), calcium channel blockers, beta blockers, vasopressin receptor 2 (V2R) antagonists, mammalian target of rapamycin (mTOR) inhibitors, somatostatin analogues, antiplatelet agents, eicosapentaenoic acids, statins and vitamin D compounds) in this review.ACEi significantly reduced diastolic blood pressure (9 studies, 278 participants: MD -4.96 mm Hg, 95% CI -8.88 to -1.04), but had uncertain effects on kidney volumes (MD -42.50 mL, 95% CI -115.68 to 30.67), GFR (MD -3.41 mL/min/1.73
Medical management of hereditary optic neuropathies.
Carelli et al., Bologna, Italy. In Front Neurol, 2013
The diagnostic workup includes neuro-ophthalmologic evaluation and genetic testing of the three most common mitochondrial DNA mutations affecting complex I (11778/ND4, 3460/ND1, and 14484/ND6) for LHON and sequencing of the nuclear gene OPA1 for DOA.
Crystal structure of the entire respiratory complex I.
Sazanov et al., Cambridge, United Kingdom. In Nature, 2013
The core fold of subunit Nqo8 (ND1 in humans) is, unexpectedly, similar to a half-channel of the antiporter-like subunits.
Identification and characterization of a novel X-linked AVPR2 mutation causing partial nephrogenic diabetes insipidus: a case report and review of the literature.
Phylactou et al., Nicosia, Cyprus. In Metabolism, 2012
In this mini-review the retrospective analysis of 13 known AVPR2 mutations that have been previously shown in vitro to partially abolish AVPR2 function is described, along with a novel mutation diagnosed in a kindred with partial nephrogenic diabetes insipidus. [Review]
Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans.
Wallace et al., Chongqing, China. In Proc Natl Acad Sci U S A, 2012
Studies indicate that NADH dehydrogenase subunit 1 (ND1) nucleotide 3394 T > C (Y30H) has been associated with Leber hereditary optic neuropathy and it reduces complex I activity and cellular respiration.
Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors.
Kolb et al., Charleston, United States. In Am J Physiol Renal Physiol, 2012
In polycystic kidney disease, structural or functional loss of cilia leads to abnormal trafficking of AQP2/V2R leading to enhanced salt and water absorption.
Novel mitochondrial DNA mutations responsible for maternally inherited nonsyndromic hearing loss.
Rocher et al., Bordeaux, France. In Hum Mutat, 2012
Novel ND1 mutations responsible for maternally inherited nonsyndromic hearing loss
A novel sensor to map auxin response and distribution at high spatio-temporal resolution.
Vernoux et al., Lyon, France. In Nature, 2012
Here we describe a novel Aux/IAA-based auxin signalling sensor termed DII-VENUS that was engineered in the model plant Arabidopsis thaliana.
Molecular organization of vomeronasal chemoreception.
Dulac et al., Cambridge, United States. In Nature, 2011
We demonstrate that the two classes (V1R and V2R) of vomeronasal receptors use fundamentally different strategies to encode chemosensory information, and that distinct receptor subfamilies have evolved towards the specific recognition of certain animal groups or chemical structures.
Mitochondrial dysfunction in autism.
Pessah et al., Davis, United States. In Jama, 2011
Deletions at the segment of cytochrome b were observed in 2 cases (ratio of cytochrome b to ND1: 0.80 [95% CI, 0.68-0.92]
A novel AVPR2 missense mutation in a Chinese boy with severe inherited nephrogenic diabetes insipidus.
Lu et al., Changsha, China. In J Pediatr Endocrinol Metab, 2010
A novel missense mutation c.506T > C (p.L169P) in AVPR2 in a patient with inherited nephrogenic diabetes insipidus.
A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2.
Diano et al., New Haven, United States. In Cell Metab, 2007
Type 2 deiodinase (DII), an enzyme that catalyzes active thyroid hormone production, and mitochondrial uncoupling protein 2 (UCP2) are also present in the hypothalamic arcuate nucleus, where their interaction and physiological significance have not been explored.
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