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DIRAS family, GTP-binding RAS-like 2

DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004] (from NCBI)
Top mentioned proteins: RAP, Inactive, RhoC, Raf, cdc25
Papers on Di-Ras2
Di-Ras2 Protein Forms a Complex with SmgGDS Protein in Brain Cytosol in Order to Be in a Low Affinity State for Guanine Nucleotides.
Kontani et al., Tokyo, Japan. In J Biol Chem, Sep 2015
Di-Ras1 and Di-Ras2 were originally identified as small GTPases forming a distinct subgroup of the Ras family.
DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders.
Lesch et al., W├╝rzburg, Germany. In Neuropsychopharmacology, 2011
Four single nucleotide polymorphisms (SNPs) and two haplotype blocks in DIRAS2 show evidence of association with attention deficit/hyperactivity disorder (ADHD) in adults.
GTPase activity of Di-Ras proteins is stimulated by Rap1GAP proteins.
Wittinghofer et al., Dortmund, Germany. In Small Gtpases, 2010
Di-Ras1 and Di-Ras2 are little characterized members of the Ras-like sub-group with still unidentified regulatory and effector proteins.
Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties.
Katada et al., Tokyo, Japan. In J Biol Chem, 2002
Here we have identified novel Ras members, human Di-Ras1 and Di-Ras2, belonging to a distinct branch of the GTPase family.
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