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Diacylglycerol kinase, zeta

DGKzeta, Diacylglycerol kinase zeta
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, MARCKS, DGKiota, V1a
Papers on DGKzeta
Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells.
Zhong et al., Shanghai, China. In Plos One, 2012
Invariant natural killer T (iNKT) cells play important roles in bridging innate and adaptive immunity via rapidly producing a variety of cytokines.
Diacylglycerol kinase zeta negatively regulates CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow.
Hammer et al., Philadelphia, United States. In Integr Biol (camb), 2012
T lymphocyte arrest within microvasculature is an essential process in immune surveillance and the adaptive immune response.
Reduction in IL-33 expression exaggerates ischaemia/reperfusion-induced myocardial injury in mice with diabetes mellitus.
Martin et al., Zhenjiang, China. In Cardiovasc Res, 2012
Finally, IL-33 up-regulated diacylglycerol kinase zeta (DGK-zeta) in cardiomyocytes and reversed the down-regulation of myocardial DGK-zeta in mice with DM.
NMDA receptor-mediated Ca(2+) influx triggers nucleocytoplasmic translocation of diacylglycerol kinase ζ under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices.
Goto et al., Yamagata, Japan. In Histochem Cell Biol, 2012
The results show that DGKzeta cytoplasmic translocation is triggered by activation of NMDAR with subsequent extracellular Ca(2+) influx.
Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.
Zhong et al., Durham, United States. In J Immunol, 2012
Antigen-specific CD8-positive T cells from DGKzeta-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8+ T cells exhibit impaired expansion.
Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins.
Goto et al., Yamagata, Japan. In Exp Cell Res, 2012
Nucleosome assembly protein (NAP) 1-like 1 (NAP1L1) and NAP1-like 4 (NAP1L4) are identified as novel DGKzeta binding partners.
Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse.
Mérida et al., Madrid, Spain. In Mol Biol Cell, 2011
DGK-zeta translocated rapidly to the plasma membrane at early stages of immunological synapse (IS) formation independent of enzyme activity; study highlights a DGKzeta-specific function for local diacylglycerol metabolism at the IS and offers new clues to its mode of regulation
Nuclear relocation of DGKζ in cardiomyocytes under conditions of ischemia/reperfusion.
Goto et al., Yamagata, Japan. In Histol Histopathol, 2011
Results suggest that DGKzeta is involved in the acute phase of cellular response to ischemic stress in cardiomyocytes
Diacylglycerol kinases in the regulation of dendritic spines.
Kim et al., Taejŏn, South Korea. In J Neurochem, 2010
Accumulating evidence indicates that synaptic levels of DAG and PA are important determinants of dendritic spine stability and that the DGKzeta isoform at excitatory postsynaptic sites is critically involved in spine maintenance.
Identification of a functional nuclear export sequence in diacylglycerol kinase-zeta.
Martelli et al., Bologna, Italy. In Cell Cycle, 2010
DGK-zeta export from nucleus to cytoplasm is regulated by a leucine-rich nuclear export signals through the exportin 1.
Brain trauma induces expression of diacylglycerol kinase zeta in microglia.
Goto et al., Yamagata, Japan. In Neurosci Lett, 2009
DGKzeta is induced in activated microglia in brain trauma, suggesting the functional significance of DGKzeta in this process.
Localization of diacylglycerol kinase epsilon on stress fibers in vascular smooth muscle cells.
Wakabayashi et al., Nishinomiya, Japan. In Cell Tissue Res, 2009
mRNA expression for DGKalpha, DGKepsilon, and DGKzeta was detected in isolated rat aortic smooth muscle cells (RASMCs) and A7r5 cells by reverse transcription with polymerase chain reaction analysis.
Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms.
Epand et al., Salt Lake City, United States. In Biochim Biophys Acta, 2009
This review discusses three of the more extensively studied forms of this enzyme, DGKalpha, DGKvarepsilon, and DGKzeta.
TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-zeta-dependent cell cycle arrest.
Martelli et al., Bologna, Italy. In Cell Signal, 2009
Nuclear diacylglycerol kinase -zeta downregulated the expression of cyclin D1 and increased the expression of Btg2 protein, a transcriptional regulator of cyclin D1 with a strong anti-proliferative function.
Diacylglycerol kinases in immune cell function and self-tolerance.
Wan et al., Durham, United States. In Immunol Rev, 2008
In mast cells, DGKzeta plays differential roles in their activation by promoting degranulation but attenuating cytokine production following engagement of the high affinity receptor for immunoglobulin E. In dendritic cells and macrophages, DGKzeta positively regulates Toll-like receptor-induced proinflammatory cytokine production through its product PA and is critical for host defense against Toxoplasma gondii infection.
Nuclear diacylglycerol kinases: regulation and roles.
Tu-Sekine et al., Baltimore, United States. In Front Biosci, 2007
In this review we focus primarily on the nuclear localization, modulation of intrinsic enzymatic activity, and the potential physiological roles of the six diacylglycerol kinases that have been found in the nucleus: DGK-alpha, DGK-gamma, DGK-delta, DGK-zeta, DGK-iota, and DGK-theta.
Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy.
Kubota et al., Yamagata, Japan. In Pharmacol Ther, 2007
In cardiac myocytes, DGKalpha, epsilon, and zeta are expressed, and DGKzeta is the predominant isoform.
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.
Zhong et al., Philadelphia, United States. In Nat Immunol, 2006
When stimulated in anergy-producing conditions, T cells lacking DGK-alpha or DGK-zeta proliferated and produced interleukin 2. Pharmacological inhibition of DGK-alpha activity in DGK-zeta-deficient T cells that received an anergizing stimulus proliferated similarly to wild-type T cells that received CD28 costimulation and prevented anergy induction.
Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.
Koretzky et al., Philadelphia, United States. In Nat Immunol, 2003
Diacylglycerol kinase zeta functions as a physiological negative regulator of tcr signaling and t-cell activation
Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta.
Prescott et al., Salt Lake City, United States. In Nature, 1998
Here we show that a fraction of DGK-zeta is found in the nucleus, where it regulates the amount of nuclear diacylglycerol.
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