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des-1, DegS, dihydroceramide desaturase
This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, htrA
Papers on des-1
From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-chlorophenyl)thiazol-2-ylamino)phenol (SKI-II).
Flynn et al., In J Med Chem, Feb 2016
However, interpretations of results using this pharmacological agent are complicated by several factors: poor SK1/2 selectivity; additional activity as an inducer of SK1-degradation; and off-target effects, including its recently identified capacity to inhibit dihydroceramide desaturase-1 (Des1).
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
Voelkel-Johnson et al., Charleston, United States. In Mol Cancer Ther, Dec 2015
ABC294640 also induced a greater than 3-fold increase in dihydroceramides that inversely correlated with inhibition of dihydroceramide desaturase (DEGS) activity.
Prediction and characterization of protein-protein interaction network in Bacillus licheniformis WX-02.
Chen et al., Wuhan, China. In Sci Rep, Dec 2015
Furthermore, the sub-network showed that a hub protein CcpA jointed directly or indirectly many proteins related to γ-PGA synthesis and regulation, such as PgsB, GltA, GltB, ProB, ProJ, YcgM and two signal transduction systems ComP-ComA and DegS-DegU.
Bacterial differentiation via gradual activation of global regulators.
Kovács, Jena, Germany. In Curr Genet, Nov 2015
In addition, other global regulators, including the two-component system DegS-DegU, modulate overlapping and complementary genes in B. subtilis related to surface colonization and biofilm formation.
Signaling in the plant cytosol: cysteine or sulfide?
Romero et al., Sevilla, Spain. In Amino Acids, Oct 2015
Another member of the OASTL family is DES1, a novel L-cysteine desulfhydrase that catalyzes the desulfuration of Cys to produce sulfide, thus acting in a manner opposite to that of OAS-A1.
Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology.
Casas et al., Barcelona, Spain. In Chem Phys Lipids, Sep 2015
UNASSIGNED: Dihydroceramide desaturase (Des1) is the last enzyme in the de novo synthesis of ceramides (Cer).
Two stress sensor proteins for the expression of sigmaE regulon: DegS and RseB.
Kim, Kyŏngsan, South Korea. In J Microbiol, May 2015
RseA, which holds sigmaE as an anti-sigma factor, is sequentially digested by DegS, RseP and cytoplasmic proteases to liberate sigmaE in response to dysfunction in outer-membrane biogenesis.
Producing human ceramide-NS by metabolic engineering using yeast Saccharomyces cerevisiae.
Funato et al., Hiroshima, Japan. In Sci Rep, 2014
In this study, we successfully developed a system that produces sphingosine-containing human ceramide-NS in the yeast Saccharomyces cerevisiae by eliminating the genes for yeast sphingolipid hydroxylases (encoded by SUR2 and SCS7) and introducing the gene for a human sphingolipid desaturase (encoded by DES1).
The Effect of Temperature on Kinetics and Diffusion Coefficients of Metallocene Derivatives in Polyol-Based Deep Eutectic Solvents.
Brandon et al., Kuala Lumpur, Malaysia. In Plos One, 2014
The temperature dependence of the measured conductivities of DES1 and DES2 are better correlated with the Vogel-Tamman-Fulcher equation.
Cysteine and cysteine-related signaling pathways in Arabidopsis thaliana.
Gotor et al., Sevilla, Spain. In Mol Plant, 2014
Thus, the discovery of novel enzymatic activities of the less-abundant, like DES1 with L-cysteine desulfhydrase activity and SCS with S-sulfocysteine synthase activity, has provided new perspectives on their roles, besides their metabolic functions.
Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression.
Francone et al., Cambridge, United States. In J Lipid Res, 2012
changes in lipid homeostasis and gene expression in Huh7 hepatocytes when the synthesis of ceramide is perturbed by knocking down serine pal mitoyltransferase subunits 1, 2, and 3 (SPTLC123) or dihydroceramide desaturase 1 (DEGS1)
Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells.
Obeid et al., Charleston, United States. In J Lipid Res, 2012
a role of the sphingolipid pathway, dihydroceramides desaturase in particular, in confluence-induced growth arrest in neuroblastoma cells
Dihydroceramide-based response to hypoxia.
Petrache et al., Indianapolis, United States. In J Biol Chem, 2011
overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia
Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance.
Cowart et al., Charleston, United States. In J Biol Chem, 2011
analysis of dihydroceramide desaturase regulation by palmitate versus monounsaturated fatty acids and its implications for insulin resistance
Dihydroceramide desaturase activity is modulated by oxidative stress.
Hannun et al., Charleston, United States. In Biochem J, 2010
oxidative stress leads to potent inhibition of dihydroceramide desaturase resulting in significant elevation in dihydroceramide levels in vivo
Allosteric activation of DegS, a stress sensor PDZ protease.
Sauer et al., Cambridge, United States. In Cell, 2007
When protein folding is compromised in the periplasm of E. coli, the C termini of outer-membrane proteins (OMPs) bind to the PDZ domains of the trimeric DegS protease and activate cleavage of RseA, a transmembrane transcriptional regulator.
Allosteric activation of a bacterial stress sensor.
Shi et al., Beijing, China. In Cell, 2007
In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS.
Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease.
Clausen et al., Vienna, Austria. In Cell, 2004
Gram-negative bacteria respond to misfolded proteins in the cell envelope with the sigmaE-driven expression of periplasmic proteases/chaperones. Activation of sigmaE is controlled by a proteolytic cascade that is initiated by the DegS protease.
A PDZ switch for a cellular stress response.
Bukau et al., Heidelberg, Germany. In Cell, 2004
The accumulation of misfolded porins in the periplasm of bacteria triggers a proteolytic cascade, initiated by activation of DegS, a member of the family of HtrA proteases.
OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain.
Sauer et al., Cambridge, United States. In Cell, 2003
This process requires a proteolytic cascade initiated by the DegS protease, which destroys a transmembrane protein (RseA) that normally binds to and inhibits sigma(E).
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