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Basic helix-loop-helix family, member e41

DEC2, BHLHB3, Sharp-1
This gene encodes a transcription factor that belongs to the Hairy/Enhancer of Split subfamily of basic helix-loop-helix factors. The encoded protein functions as a transcriptional repressor and as a regulator of molecular clock. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: DEC1, CLOCK, ACID, HAD, Tic
Papers on DEC2
The detection and mapping of the spatial distribution of insect defense compounds by desorption atmospheric pressure photoionization Orbitrap mass spectrometry.
Cvačka et al., Praha, Czech Republic. In Anal Chim Acta, Aug 2015
Then, the spatial distribution of the unsaturated aldehydes (E)-hex-2-enal, (E)-4-oxohex-2-enal, (E)-oct-2-enal, (E,E)-deca-2,4-dienal and (E)-dec-2-enal was monitored in the stink bug Graphosoma lineatum.
Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex.
Rossner et al., Göttingen, Germany. In Proc Natl Acad Sci U S A, Aug 2015
SHARP1/DEC2 has been shown to control sleep length in humans and sleep architecture is also altered in double mutant mice (S1/2(-/-)).
Reactions of green lizards (Lacerta viridis) to major repellent compounds secreted by Graphosoma lineatum (Heteroptera: Pentatomidae).
Černíková et al., Praha, Czech Republic. In Zoology (jena), Jun 2015
We tested the aversive reactions of green lizards (Lacerta viridis) towards the major compounds of the defensive secretion of Graphosoma lineatum, specifically: (i) a mixture of three aldehydes: (E)-hex-2-enal, (E)-oct-2-enal, (E)-dec-2-enal; (ii) a mixture of these three aldehydes and tridecane; (iii) oxoaldehyde: (E)-4-oxohex-2-enal; (iv) secretion extracted from metathoracic scent glands of G. lineatum adults and (v) hexane as a non-polar solvent.
Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells.
Kijima et al., Hirosaki, Japan. In Biomed Res, 2014
DEC1 [basic helix-loop-helix (BHLH) E40/Stra13/Sharp2] and DEC2 (BHLHE41/Sharp1) are BHLH transcription factors that are associated with the regulation of apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers.
DEC2-E4BP4 Heterodimer Represses the Transcriptional Enhancer Activity of the EE Element in the Per2 Promoter.
Takumi et al., Hiroshima, Japan. In Front Neurol, 2014
Other circadian transcription regulators, particularly E4BP4 and DEC2, regulate the amplitude and phase of Per2 expression rhythms.
DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas.
Yang et al., Shanghai, China. In J Exp Clin Cancer Res, 2014
HIF-1 (hypoxia-inducible factor 1) activation is critical for the metabolic reprogramming and progression of solid tumors, and DEC2 (differentiated embryonic chondrocyte gene 2) has been recently reported to suppress HIF-1 in human breast and endometrial cancers.
Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis.
Mandelin et al., Helsinki, Finland. In Plos One, 2014
Our objective was to investigate the expression of direct clock suppressors DEC1 and DEC2 (BHLHE 40 and 41 proteins) in response to TNFα and investigate their role during inflammation.
DEC1/STRA13/SHARP2 and DEC2/SHARP1 coordinate physiological processes, including circadian rhythms in response to environmental stimuli.
Noshiro et al., Hiroshima, Japan. In Curr Top Dev Biol, 2013
Clock proteins DEC1 (BHLHe40) and DEC2 (BHLHe41) belong to the basic helix-loop-helix protein superfamily, which contains other clock proteins CLOCK and BMAL1.
TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling.
Aguirre-Ghiso et al., United States. In Nat Cell Biol, 2013
This results in induction of DEC2/SHARP1 and p27, downregulation of cyclin-dependent kinase 4 (CDK4) and dormancy of malignant DTCs.
Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function.
Fu et al., San Francisco, United States. In Curr Opin Neurobiol, 2013
To support our hypothesis, we review Mendelian human genetic variants sufficient to advance sleep-wake onset (PER2) and shorten sleep length (DEC2), and evaluate their emerging roles in immune responses that may rely on a sound night of slumber.
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.
Piccolo et al., Padova, Italy. In Nature, 2012
SHARP1 is required, and sufficient, to limit expression of HIF-target genes
Time-dependent interaction between differentiated embryo chondrocyte-2 and CCAAT/enhancer-binding protein α underlies the circadian expression of CYP2D6 in serum-shocked HepG2 cells.
Ohdo et al., Fukuoka, Japan. In Mol Pharmacol, 2012
results suggest that DEC2 periodically represses the promoter activity of CYP2D6, resulting in its circadian expression in serum-shocked cells
BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral cancer HSC-3 cells.
Kijima et al., Hirosaki, Japan. In Biomed Res, 2012
DEC2 regulates apoptosis in oral cancer cells via regulation of pro-apoptotic factor Bim expression
Genetic interaction of Per1 and Dec1/2 in the regulation of circadian locomotor activity.
Oster et al., Göttingen, Germany. In J Biol Rhythms, 2011
Results suggest a partially redundant and bidirectional regulatory function for Dec1/2 genes in transcriptional translational feedback loops and conservation of Per1-Dec synergism between vertebrate and invertebrate clocks.
Advanced light-entrained activity onsets and restored free-running suprachiasmatic nucleus circadian rhythms in per2/dec mutant mice.
Oster et al., Göttingen, Germany. In Chronobiol Int, 2011
measured circadian locomotor behavior and clock gene expression in the SCN of Per2/Dec1/2 double- and triple-mutant mice to analyze the functional interaction of PER2 and DEC1/2 feedback on circadian pacemaker function in the SCN
The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network.
Boominathan, Pondicherry, India. In Cancer Metastasis Rev, 2010
In particular, p53 and TA-p73/p63 appear to upregulate the expression of (1) tumor suppressor miRNAs, such as let-7, miR-34, miR-15/16a, miR-145, miR-29, miR-26, miR-30, and miR-146a; (2) tumor suppressor genes, such as PTEN, RBs, CDKN1a/b/c, and CDKN2a/b/c/d; (3) metastasis suppressors, such as Raf kinase inhibitory protein, CycG2, and DEC2, and thereby they enlarge their tumor suppressor network to inhibit tumorigenesis, invasion, angiogenesis, migration, metastasis, and CSCs proliferation.
The transcriptional repressor DEC2 regulates sleep length in mammals.
Fu et al., San Francisco, United States. In Science, 2009
study identified a mutation, P385R, in DEC2 associated with a short sleep phenotype; activity profiles & sleep recordings of transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice
Microarray-based understanding of normal and malignant plasma cells.
Klein et al., Montpellier, France. In Immunol Rev, 2006
This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surface molecules such as CD138/syndecan-1, and for the unfolded protein response.
Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli.
Miyamoto et al., Fukui, Japan. In Front Biosci, 2004
Of the basic helix-loop-helix (bHLH) proteins binding to the E box sequence, class B of bHLH proteins, BHLHB2 (also referred to as the DEC1/Eip1/SHARP-2/Stra13/Clast5) and BHLHB3 (also referred to as the DEC2/SHARP-1/SHARP1), are transcription factors that contain a unique orange domain.
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