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Translocase of inner mitochondrial membrane 8 homolog B

This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: DDP1, CAN, Actin, SET, SIMPLE
Papers on DDP2
Novel germline SDHD deletion associated with an unusual sympathetic head and neck paraganglioma.
Cabanillas et al., Spain. In Head Neck, 2011
RESULTS: A previously unreported chromosome 11q deletion encompassing 5 annotated genes (SDHD, DLAT, PIH1D2, C11Orf57, and TIMM8B) was detected in the proband.
Mitochondrial inhibition during preimplantation embryogenesis shifts the transcriptional profile of fetal mouse brain.
Lane et al., Adelaide, Australia. In Reprod Fertil Dev, 2010
Only 2/48 genes had significantly altered expression by qPCR (Nola3, Timm8b) in fetal brains exposed to 50 μM AOA embryo culture, excluding an AOA dose-dependent response.
Molecular characterization of novel germline deletions affecting SDHD and SDHC in pheochromocytoma and paraganglioma patients.
Vriends et al., Leiden, Netherlands. In Endocr Relat Cancer, 2009
One patient had a 10 kb AluSg-AluSx-mediated deletion including SDHD exons 1 and 2, the entire TIMM8B gene, and deletion of exons of C11orf57.
Composition analysis and antioxidant activity of polysaccharide from Dendrobium denneanum.
Chun et al., Chengdu, China. In Int J Biol Macromol, 2009
Three polysaccharide fractions (DDP1-1, DDP2-1 and DDP3-1) were successfully purified from the crude polysaccharide of Dendrobium denneanum by DEAE-Cellulose and Sephadex G-200 column chromatography.
Gene profiling during development and after a peripheral nerve traumatism reveals genes specifically induced by injury in dorsal root ganglia.
Carroll et al., Montpellier, France. In Mol Cell Neurosci, 2006
Focusing on this latter event highlights Ddit3, Timm8b and Oazin as potential new injury-induced molecular actors involved in a stress response pathway.
Expression vectors for studying cytoskeletal proteins in Dictyostelium discoideum.
Manstein et al., Heidelberg, Germany. In J Muscle Res Cell Motil, 2001
coli shuttle vector pDXA-3H (6.1 kb), which carries the origin of replication of the Dd high-copy-number plasmid, Ddp2, a high-copy-number E. coli plasmid origin of replication, an act6 promoter driven G418 resistance cassette, the bacterial ampicillin resistance gene and an expression cassette.
Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing loss.
Schofield et al., Sydney, Australia. In Genes Chromosomes Cancer, 2001
The SDHD region contains another gene, DPP2/TIMM8B, the homolog of which causes dystonia and deafness seen in Mohr-Tranebjaerg syndrome.
A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region.
Devlin et al., Pittsburgh, United States. In Eur J Hum Genet, 2001
We also discover a processed pseudogene for USA-CYP, a cyclophilin associated with U4/U6 snRPNs, and a novel gene, DDP2, encoding a mitochondrial protein similar to the X-linked deafness-dystonia protein, which is juxtaposed 5'-to-5' to SDHD.
Green fluorescent protein and epitope tag fusion vectors for Dictyostelium discoideum.
Egelhoff et al., Cleveland, United States. In Plasmid, 2000
Each fusion cartridge was placed either in a G418-resistance vector allowing transactivated Ddp2-based extrachromosomal replication or in a vector allowing autonomous Ddp1-based replication.
Mechanism of action of the Rep protein from the Dictyostelium Ddp2 plasmid family.
Welker et al., Dallas, United States. In Plasmid, 1999
The two-hybrid system was used to show that the Rep proteins from three members of the Dictyostelium discoideum Ddp2 plasmid family, Ddp2, Ddp5, and Ddp6, form homomultimers but not heteromultimers when expressed in yeast cells.
Dgp1 and Dfp1 are closely related plasmids in the Dictyostelium Ddp2 plasmid family.
Welker et al., Logan, United States. In Plasmid, 1999
Dictyostelium plasmids Dgp1 and Dfp1, two members of the Ddp2 plasmid family, are 86% identical in nucleotide sequence.
Alteration in p53 pathway and defect in apoptosis contribute independently to cisplatin-resistance.
Jacquemin-Sablon et al., Villejuif, France. In Cell Death Differ, 1998
The accumulation of molecular genetic defects selected during the adaptation process in the development of cisplatin-resistance was studied using progressive cisplatin-resistant variants (L1210/DDP2, L1210/DDP5, L1210/DDP10) derived from a murine leukemia cell line (L1210/0).
Dictyostelium discoideum nuclear plasmid Ddp5 is a chimera related to the Ddp1 and Ddp2 plasmid families.
Welker et al., Logan, United States. In Genetics, 1998
One of these is related to the rep gene of the Ddp2 plasmid, and the other five are related to genes present on the Ddp1 plasmid.
Dictyostelium discoideum nuclear plasmid Ddp6 is a new member of the Ddp2 plasmid family.
Welker et al., Logan, United States. In Curr Genet, 1998
The complete nucleotide sequence, 5257 bp, shows that Ddp6 has a structure similar to that of other members of the Ddp2 plasmid family: a single long 2.8-kb open reading frame (rep gene) and an inverted repeat containing a pair of 654-bp elements.
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