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Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Dicer, DRB1, DR4, PrP, CAN
Papers on DcR2
β-catenin is regulated by USP9x and mediates resistance to TRAIL-induced apoptosis in breast cancer.
Xie et al., Wuhan, China. In Oncol Rep, Feb 2016
Luciferase assay was used to examine activity of the DcR1/DcR2/OPG reporter.
Radiation-induced loss of salivary gland function is driven by cellular senescence and prevented by IL-6 modulation.
Axelrod et al., In Cancer Res, Feb 2016
We demonstrate that the loss of salivary function was closely accompanied by cellular senescence, as evidenced by a persistent DNA damage response (γH2AX, 53BP1) and the expression of senescence-associated markers (SA-βgal, p19ARF, DcR2) and secretory phenotype (SASP) factors (PAI-1, IL-6).
SNP-SNP interaction analysis of NF-κB signaling pathway on breast cancer survival.
Nevanlinna et al., Helsinki, Finland. In Oncotarget, Dec 2015
Based on in silico functional analyses and literature, we speculate that the rs5996080 and rs7973914 loci may affect the BAFFR and TNFR1/TNFR3 receptors and breast cancer survival, possibly by disturbing both the canonical and non-canonical NF-κB pathways or their dynamics, whereas, rs17243893-rs57890595 interaction on survival may be mediated through TRAF2-TRAIL-R4 interplay.
Insulin promotes VSMC proliferation and apoptosis via differential regulation of TNF-related apoptosis inducing ligand.
Kavurma et al., Sydney, Australia. In J Diabetes, Oct 2015
Furthermore, insulin, but not glucose was able to promote VSMC proliferation over time, associated with increased DcR2 expression.
RAD001 (everolimus) enhances TRAIL cytotoxicity in human leukemic Jurkat T cells by upregulating DR5.
Yoo et al., Seoul, South Korea. In Biochem Biophys Res Commun, Sep 2015
Investigation of the effect of RAD001 treatment on the expression of TRAIL receptors (TRAIL-Rs) in Jurkat T cells showed that RAD001 significantly upregulated DR5 by up to 51.22%, but not other TRAIL-Rs such as DR4 (TRAIL-R1), decoy receptor (DcR) 1 (TRAIL-R3), and DcR2 (TRAIL-R4).
Mutations Enhancing Selectivity of Antitumor Cytokine TRAIL to DR5 Receptor Increase Its Cytotoxicity against Tumor Cells.
Kirpichnikov et al., Moscow, Russia. In Biochemistry (mosc), Aug 2015
The resistance is partially related to interaction of TRAIL with the decoy receptors DcR1 and DcR2, which do not trigger the apoptotic signal and inhibit signaling of death receptors.
Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.
Szegezdi et al., Galway, Ireland. In Oncogene, Jul 2015
The inhibitory decoy receptors (DcR1 and DcR2) co-expressed with death receptor 4 (DR4)/DR5 on the same cell can block the transmission of the apoptotic signal.
Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma.
Alici et al., Huddinge, Sweden. In Plos One, 2014
In vitro analysis revealed a higher resistance to bortezomib possibly due to an altered gene expression profile caused by del(8)(p21) including genes such as TRAIL-R4, CCDC25, RHOBTB2, PTK2B, SCARA3, MYC, BCL2 and TP53.
The osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the kidney.
Candido, Trieste, Italy. In Curr Opin Nephrol Hypertens, 2014
The actions of TRAIL are regulated by three decoy receptors, TRAIL-R3, TRAIL-R4 and osteoprotegerin (OPG).
Regulation of TRAIL-receptor expression by the ubiquitin-proteasome system.
Lundqvist et al., Stockholm, Sweden. In Int J Mol Sci, 2013
Conversely the decoy receptors TRAIL-R3 and TRAIL-R4, which lack the pro-apoptotic death domain, function to dampen the apoptotic response by competing for TRAIL ligand.
Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila.
Orlando et al., Roma, Italy. In Nature, 2012
Here we show that the key RNAi components Dicer 2 (DCR2) and Argonaute 2 (AGO2) associate with chromatin (with a strong preference for euchromatic, transcriptionally active, loci) and interact with the core transcription machinery.
Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer.
Hsieh et al., Taipei, Taiwan. In Biochem Pharmacol, 2011
Recently, several decoy molecules belonging to tumor necrosis factor receptor superfamily (TNFRSF) have been identified, including decoy receptor 1 (DcR1), decoy receptor 2 (DcR2), and decoy receptor 3 (DcR3).
Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma.
Hayward et al., Brisbane, Australia. In Plos One, 2010
transcript levels of UCHL1, COL1A2, THBS1 and TNFRSF10D were inversely correlated with promoter methylation
Hypoxia-induced decoy receptor 2 gene expression is regulated via a hypoxia-inducible factor 1alpha-mediated mechanism.
Lin et al., Taipei, Taiwan. In Biochem Biophys Res Commun, 2010
these results demonstrated that hypoxia-inducible factor 1alpha played a crucial role in regulating the transcription of DcR2.
Inhibition of apoptosis in periodontitis.
Haynes et al., Adelaide, Australia. In J Dent Res, 2010
Higher levels of TRAIL and the TRAIL decoy receptor, TRAIL R4, were expressed by leukocytes in inflamed human periodontal tissues.
TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis.
Sanlioglu et al., Antalya, Turkey. In Bmc Musculoskelet Disord, 2009
TRAIL receptor-4 expression profiles on T cells might be important in revelation of rheumatoid arthritis pathogenesis.
Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression.
Kim et al., Seoul, South Korea. In Mol Cancer, 2009
ANT2 shRNA treatment sensitized MCF7, T47 D, and BT474 cells to TRAIL-induced apoptosis by up-regulating the expression of TRAIL death receptors 4 and 5 (DR4 and DR5) and down-regulating the TRAIL decoy receptor 2 (DcR2).
Emerging role of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) as a key regulator of inflammatory responses.
Mattes et al., Newcastle, Australia. In Clin Exp Pharmacol Physiol, 2009
Cleavage of the BH-3 only peptide Bid by caspase 8 links the apoptotic TRAIL signal to the mitochondrial pathway and the subsequent release of cytochrome c. 2. In addition, TRAIL binds to neutralizing decoy receptors (DcR1 and DcR2).
Trail and kidney disease.
Ortiz et al., Madrid, Spain. In Front Biosci, 2008
TRAIL may modulate cell survival and proliferation through interaction with two different receptors, TRAIL-R1 and TRAIL-R2, and the actions of TRAIL are regulated by three decoy receptors, TRAIL-R3, TRAIL-R4 and osteoprotegerin.
The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain.
Goodwin et al., Seattle, United States. In Immunity, 1997
A fourth member of the emerging TRAIL receptor family, TRAIL-R4, has been cloned and characterized.
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