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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Deleted in colorectal carcinoma

Top mentioned proteins: netrin-1, CAN, p53, HAD, V1a
Papers using DCC antibodies
Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression
Ström Anders et al., In Breast Cancer Research : BCR, 1996
... 5% dextran-coated charcoal-treated FBS (DCC) for 24 hours; The serum was then reduced to 0.5% DCC before 10 nM ICI 182,780 (ICI) (Tocris, St ...
Papers on DCC
Direct measurement of oscillatory RhoA activity in embryonic cortical neurons stimulated with the axon guidance cue netrin-1 using FRET.
Lamarche-Vane et al., Montréal, Canada. In Biol Cell, Feb 2016
Signaling downstream of the axon guidance cue netrin-1 and its receptor Deleted in Colorectal Cancer (DCC) triggers the activation of Rac1 and the inhibition of RhoA to promote axon outgrowth.
Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.
Kania et al., Montréal, Canada. In J Neurosci, Feb 2016
Consistent with cell-autonomous degeneration, we demonstrate defects in the trafficking of the synaptic proteins Syntaxin1a and PSD-95 and the TrkB and DCC receptors in Munc18-1(-/-) neurons; these defects do not appear to cause ER stress, suggesting other mechanisms for degeneration.
p120RasGAP mediates netrin-1-induced cortical axon outgrowth and guidance.
Lamarche-Vane et al., Canada. In J Biol Chem, Jan 2016
UNASSIGNED: The receptor Deleted in Colorectal Cancer (DCC) mediates attraction of growing axons to netrin-1 during brain development.
The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance.
Gupton et al., Chapel Hill, United States. In Dev Cell, Jan 2016
Here, we demonstrate that TRIM9, an E3 ubiquitin ligase that localizes to filopodia tips and binds the netrin receptor DCC, interacts with and ubiquitinates the barbed-end polymerase VASP to modulate filopodial stability during netrin-dependent axon guidance.
SYD-1 Promotes Multiple Developmental Steps Leading to Neuronal Connectivity.
Quinn et al., Milwaukee, United States. In Mol Neurobiol, Jan 2016
We discuss interactions between SYD-1, UNC-40(DCC) and RhoGTPases and highlight both similarities and differences in how SYD-1 functions to regulate the different steps of axonal development.
EPR Studies of V-ATPase with Spin-Labeled Inhibitors DCC and Archazolid: Interaction Dynamics with Proton Translocating Subunit c.
Menche et al., Bonn, Germany. In Chemmedchem, Jan 2016
Spin labeling of the V-ATPase holoenzyme from the tobacco hornworm Manduca sexta and V-ATPase in isolated yeast (Saccharomyces cerevisiae) vacuoles was accomplished by two novel methods involving the covalent binding of a (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) derivative of N,N'-dicyclohexylcarbodiimide (DCC) to the essential glutamate residue in the active site and the noncovalent interaction of a radical analogue of the highly potent inhibitor archazolid, a natural product from myxobacteria.
Lack of netrin-4 modulates pathologic neovascularization in the eye.
Joussen et al., Berlin, Germany. In Sci Rep, Dec 2015
Expression of netrin receptors, Unc5H2 (Unc-5 homolog B, C. elegans) and DCC (deleted in colorectal carcinoma), was found in Müller cells and astrocytes.
Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2.
Tessier-Lavigne et al., San Francisco, United States. In Science, Dec 2015
Robo3, a Robo family member, allows commissural axons to reach and cross the spinal cord midline by antagonizing Robo1/2-mediated repulsion from midline-expressed Slits and potentiating deleted in colorectal cancer (DCC)-mediated midline attraction to Netrin-1, but without binding either Slits or Netrins.
Signaling mechanism of the netrin-1 receptor DCC in axon guidance.
Wang et al., Beijing, China. In Prog Biophys Mol Biol, Sep 2015
DCC (Deleted in Colorectal Cancer) is a single-pass transmembrane protein that belongs to the immunoglobulin superfamily.
Condensin-driven remodelling of X chromosome topology during dosage compensation.
Meyer et al., Berkeley, United States. In Nature, Aug 2015
The dosage compensation complex (DCC), a condensin complex, binds to both hermaphrodite X chromosomes via sequence-specific recruitment elements on X (rex sites) to reduce chromosome-wide gene expression by half.
Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets.
Hirsch et al., Groningen, Netherlands. In Chem Soc Rev, May 2015
Dynamic combinatorial chemistry (DCC) has emerged as a powerful strategy to identify ligands for biological targets given that it enables the target to direct the synthesis and amplification of its strongest binder(s) from the library of interconverting compounds.
Molecular biomarkers in colorectal carcinoma.
Calleja-Hernández et al., Granada, Spain. In Pharmacogenomics, 2014
Gene alterations described for colorectal cancer include genome instability (microsatellite and chromosomal instability), CpG islands methylator phenotype, microRNA, histone modification, protein biomarkers, gene mutations (RAS, BRAF, PI3K, TP53, PTEN) and polymorphisms (APC, CTNNB1, DCC).
Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.
Nikolov et al., New York City, United States. In Science, 2014
Deleted in colorectal cancer (DCC) is a well-established netrin-1 receptor mediating attractive responses.
Dynamic combinatorial/covalent chemistry: a tool to read, generate and modulate the bioactivity of compounds and compound mixtures.
Herrmann, Genève, Switzerland. In Chem Soc Rev, 2014
Dynamic combinatorial/covalent chemistry (DCC) has been used to read structural information by selectively assembling receptors with the optimum molecular fit around a given template from a mixture of reversibly reacting building blocks.
Condensin-mediated chromosome organization and gene regulation.
Csankovszki et al., Ann Arbor, United States. In Front Genet, 2013
In Caenorhabditis elegans, dosage compensation is achieved by the dosage compensation complex (DCC) binding to both X chromosomes in hermaphrodites to downregulate gene expression by twofold.
Robo2--slit and Dcc--netrin1 coordinate neuron axonal pathfinding within the embryonic axon tracts.
Peng et al., Shanghai, China. In J Neurosci, 2012
Dcc-Netrin1 and roundabout2 (Robo2)-Slit coordinate axonal projection choices of neurons in the developing forebrain.
Dcc regulates asymmetric outgrowth of forebrain neurons in zebrafish.
Peng et al., Shanghai, China. In Plos One, 2011
Dcc regulates polarized axon initiation and asymmetric outgrowth of forebrain neurons
Netrin/DCC signaling controls contralateral dendrites of octavolateralis efferent neurons.
Chien et al., Salt Lake City, United States. In J Neurosci, 2007
First evidence that Netrin/DCC axon guidance molecules act in dendrites in a vertebrate system.
Cloning of full-length zebrafish dcc and expression analysis during embryonic and early larval development.
Chien et al., Salt Lake City, United States. In Dev Dyn, 2005
dcc may play roles not only in axon guidance, but in morphogenesis and functioning of these organs as well
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