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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

F-box protein 8

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, HAD, HLA-G, CAN, V1a
Papers using DC10 antibodies
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
Richardson Andrea L et al., In Breast Cancer Research : BCR, 2008
antibody, BD Biosciences, San Jose, CA, USA), CK18 (DC10 antibody, Dako) and CK19 (RCK108 antibody, ...
Papers on DC10
Elevation of HLA-G-expressing DC-10 cells in patients with gastric cancer.
Yan et al., Linhai, China. In Hum Immunol, Feb 2016
UNASSIGNED: DC-10 is a distinct subset of human tolerogenic dendritic cells (DCs) which express high levels of human leukocyte antigen-G (HLA-G).
HLA-G expression levels influence the tolerogenic activity of human DC-10.
Gregori et al., Milano, Italy. In Haematologica, Apr 2015
Our group identified a subset of human dendritic cells, named DC-10, that induce adaptive interleukin-10-producing T regulatory type 1 (Tr1) cells via the interleukin-10-dependent HLA-G/ILT4 pathway.
HLA-G Orchestrates the Early Interaction of Human Trophoblasts with the Maternal Niche.
Panina-Bordignon et al., Milano, Italy. In Front Immunol, 2014
HLA-G, a non-classical HLA class I molecule endowed with immune-regulatory functions, is primarily expressed on EVTs lining the placenta and on the naturally occurring tolerogenic dendritic cells, named DC-10, which are enriched in the human first trimester decidua.
New insights into HLA-G mediated tolerance.
Gregori et al., Milano, Italy. In Tissue Antigens, 2014
The recent discovery of dendritic cells-10 (DC-10) as naturally occurring HLA-G-expressing dendritic cells opens new perspectives in the identification of the molecular and cellular mechanisms underlying HLA-G-mediated tolerance.
HLA-G expression on blasts and tolerogenic cells in patients affected by acute myeloid leukemia.
Gregori et al., Milano, Italy. In J Immunol Res, 2013
Our group identified a subset of tolerogenic dendritic cells, DC-10 that express HLA-G and secrete IL-10.
Regulatory dendritic cell expression of MHCII and IL-10 are jointly requisite for induction of tolerance in a murine model of OVA-asthma.
Gordon et al., Saskatoon, Canada. In Allergy, 2013
BACKGROUND: Allergen-presenting dendritic cells differentiated with IL-10 (DC10) reverse the asthma phenotype in mice by converting their Th2 cells to regulatory T cells (Tregs).
Comparison of induced versus natural regulatory T cells of the same TCR specificity for induction of tolerance to an environmental antigen.
Gordon et al., Saskatoon, Canada. In J Immunol, 2013
The iTreg were differentiated from Th2 effector T cells by exposure to IL-10-differentiated dendritic cells (DC10) in vitro or in vivo, whereas we purified nTreg from allergen-naive mice and exposed them to DC10 before use.
HLA-G expressing DC-10 and CD4(+) T cells accumulate in human decidua during pregnancy.
Gregori et al., Milano, Italy. In Hum Immunol, 2013
We recently identified a subset of tolerogenic dendritic cells, DC-10 that secrete high amounts of IL-10 and express high levels of HLA-G and its ligand ILT4.
[Roles of interleukin-10 differentiated dendritic cell of allergic asthma patients in T-lymphocyte proliferation in vitro].
Wang et al., Changzhou, China. In Zhonghua Yi Xue Za Zhi, 2012
OBJECTIVE: To explore the roles of interleukin (IL)-10 differentiated peripheral blood monocyte-derived dendritic cell (DC-10) of allergic asthma patients in T-lymphocytes proliferation in vitro.
Infectious endogenous retroviruses in cats and emergence of recombinant viruses.
Nishigaki et al., Yamaguchi, Japan. In J Virol, 2012
One of these, ERV-DC10, located in the q12-q21 region on chromosome C1, is an infectious gammaretrovirus capable of infecting a broad range of cells, including human.
Induction of prolonged asthma tolerance by IL-10-differentiated dendritic cells: differential impact on airway hyperresponsiveness and the Th2 immunoinflammatory response.
Gordon et al., Saskatoon, Canada. In J Immunol, 2012
At 13 wk, AHR returned to pretreatment levels but could again be reversed by DC10 retreatment.
Human tolerogenic DC-10: perspectives for clinical applications.
Gregori et al., Milano, Italy. In Transplant Res, 2011
Addition of IL-10 during monocyte-derived DC differentiation allows the induction of DC-10, a subset of human tolerogenic DCs characterized by high IL-10/IL-12 ratio and co-expression of high levels of the tolerogenic molecules HLA-G and immunoglobulin-like transcript 4. DC-10 are potent inducers of adaptive type 1 regulatory T cells, well known to promote and maintain peripheral tolerance.
Therapeutic induction of tolerance by IL-10-differentiated dendritic cells in a mouse model of house dust mite-asthma.
Gordon et al., Hangzhou, China. In Allergy, 2011
delivery of dendritic cells differentiated with IL-10 alone (DC10) does not.
c-Myc stimulates cell invasion by inhibiting FBX8 function.
Kim et al., Suwŏn, South Korea. In Mol Cells, 2010
FBX8 is a novel c-Myc binding protein and that c-Myc induces cell invasive activity
Role of human leukocyte antigen-G in the induction of adaptive type 1 regulatory T cells.
Roncarolo et al., Milano, Italy. In Hum Immunol, 2009
We recently described a subset of human DC, termed DC-10, that express high levels of HLA-G and ILT4, secrete high amounts of IL-10, and induce allospecific Tr1 cells in vitro via an IL-10-dependent ILT4/HLA-G pathway.
Role of commercial aircraft in global monitoring systems.
Steinberg, In Science, 1973
The new family of wide-bodied jets such as the 747, DC-10, and L-1011 aircraft can be used to supply important global atmospheric and tropical meteorological data for which there is a pressing need.
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