Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression.
Saint Louis, United States. In Neurobiol Aging, Jan 2016
We used 2 PD case-control data sets (Washington University and the Parkinson's Progression Markers Initiative) to determine whether polymorphisms located at the GWAS top hits (GBA, ACMSD/TMEM163, STK39, MCCC1/LAMP3, GAK/TMEM175, SNCA, and MAPT) show association with AAO or motor progression.
Structural and molecular regulation of lung maturation by intratracheal VEGF administration in the normally grown and placentally restricted fetus.
Adelaide, Australia. In J Physiol, Dec 2015
We examined the effect on expression of genes regulating VEGF signalling (FLK and KDR), angiogenesis (ANGTP1, AQP1, ADM), alveolarisation (MMP2, MMP9, TIMP1, COL1A1, ELN), proliferation (IGR1, IGF2, IGF1R, MKI67, PCNA), inflammation (CCL2, CCL4, IL1B, TNFA, TGFB1, IL10) and surfactant maturation (SFTP-A, SFTP-B, SFTP-C, SFTP-D, PCYT1A, LPCAT, LAMP3, ABCA3).
Oral syphilis: report of three cases and characterization of the inflammatory cells.
São José dos Campos, Brazil. In Ann Diagn Pathol, Apr 2015
Immunohistochemical reactions for XIIIa, CD3, CD20, CD68, CD163, S100, CD1a, CD11c, CD83, CD138, and CD208 were performed.
Molecular patterns of subclinical and clinical rejection of kidney allograft: quantity matters.
Praha, Czech Republic. In Kidney Blood Press Res, 2014
RESULTS: Clinical inflammation group showed a increased expression of genes for chemotaxis mediating cytokines (CCL1, CCL17, CCL24, CCL25, CCL26), cytokine receptors (CCR1, CCRL2, IL1RAPL2, CXCR5), proinflammatory cytokines (IL12A, LTA), inflammatory mediator (PTAFR), complement protein C3, executioner protein of apoptosis (CASP7), growth factor (TGFA), colony stimulating factor (CSF-2), proteins involved in dendritic cells differentiation and interaction (CD209, LAMP3), regulation of immune response (LILRB2, LILBRB4).
Genetics of Parkinson's disease and essential tremor.
Vienna, Austria. In Curr Opin Neurol, 2011
RECENT FINDINGS: Within the last two years, genome-wide association (GWA) analyses have revealed a number of novel low-risk susceptibility variants for Parkinson's disease, among them HLA-DRB5, BST1, ACMSD, STK39, MCCC1/LAMP3, SYT11, and CCDC62/HIP1R) and have confirmed LINGO1 as risk factor for essential tremor.