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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Lysosomal-associated membrane protein 3

Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010] (from NCBI)
Top mentioned proteins: CD83, CD1, DC-SIGN, HAD, CAN
Papers on DC-LAMP
Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression.
Cruchaga et al., Saint Louis, United States. In Neurobiol Aging, Jan 2016
We used 2 PD case-control data sets (Washington University and the Parkinson's Progression Markers Initiative) to determine whether polymorphisms located at the GWAS top hits (GBA, ACMSD/TMEM163, STK39, MCCC1/LAMP3, GAK/TMEM175, SNCA, and MAPT) show association with AAO or motor progression.
Histological and immunohistochemical studies on primary intracranial canine histiocytic sarcomas.
Nakayama et al., Tokyo, Japan. In J Vet Med Sci, Jan 2016
Immunohistochemically, tumor cells were strongly positive for HLA-DR, Iba-1 and CD204 in all the 23 cases, for iNOS in 20, for CD163 in 17, for lysozyme and CD208 (DC-LAMP) in 9, and for S100 in 5 cases.
Structural and molecular regulation of lung maturation by intratracheal VEGF administration in the normally grown and placentally restricted fetus.
Morrison et al., Adelaide, Australia. In J Physiol, Dec 2015
We examined the effect on expression of genes regulating VEGF signalling (FLK and KDR), angiogenesis (ANGTP1, AQP1, ADM), alveolarisation (MMP2, MMP9, TIMP1, COL1A1, ELN), proliferation (IGR1, IGF2, IGF1R, MKI67, PCNA), inflammation (CCL2, CCL4, IL1B, TNFA, TGFB1, IL10) and surfactant maturation (SFTP-A, SFTP-B, SFTP-C, SFTP-D, PCYT1A, LPCAT, LAMP3, ABCA3).
Characterization of type I interferon pathway during hepatic differentiation of human pluripotent stem cells and hepatitis C virus infection.
Arumugaswami et al., Los Angeles, United States. In Stem Cell Res, Sep 2015
Hepatitis C virus replication in hESC-derived hepatic cells induced the expression of ISGs--LAMP3, ETV7, RASGRP3, and TRANK1.
Oral syphilis: report of three cases and characterization of the inflammatory cells.
Kaminagakura et al., São José dos Campos, Brazil. In Ann Diagn Pathol, Apr 2015
Immunohistochemical reactions for XIIIa, CD3, CD20, CD68, CD163, S100, CD1a, CD11c, CD83, CD138, and CD208 were performed.
Immunomodelling Characteristics of Mature Dendritic Cells Stimulated by Colon Cancer Cells Lysates.
Maciejewski et al., In Pol Przegl Chir, Feb 2015
RESULTS: DC`s generated from colon cancer patients stimulated with lysates presented greater maturity, lower expression of CD206 antigen, significantly higher expression of HLA-DR, CD208 and CD209 and high intracellular expression of IL-12, compared to non-stimulated cells.
Analysis of the intratumoral adaptive immune response in well differentiated and dedifferentiated retroperitoneal liposarcoma.
Hwu et al., Los Angeles, United States. In Sarcoma, 2014
Intratumoral TLS may be sites of antigen presentation as DC-LAMP positive, mature dendritic cells were found juxtaposed next to CD4 T cells.
High Expression of LAMP3 Is a Novel Biomarker of Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
Jia et al., Guangzhou, China. In Int J Mol Sci, 2014
Lysosomal-associated membrane protein 3 (LAMP3), identified as a molecular marker of mature dendritic cells, is one of the LAMP family members.
LAMP3 and TP53 overexpression predicts poor outcome in laryngeal squamous cell carcinoma.
Wang et al., Nantong, China. In Int J Clin Exp Pathol, 2014
Lysosomal associated membrane protein 3 (LAMP3) is a newly identified tumor-specific and hypoxia-induced protein.
Molecular patterns of subclinical and clinical rejection of kidney allograft: quantity matters.
Viklicky et al., Praha, Czech Republic. In Kidney Blood Press Res, 2014
RESULTS: Clinical inflammation group showed a increased expression of genes for chemotaxis mediating cytokines (CCL1, CCL17, CCL24, CCL25, CCL26), cytokine receptors (CCR1, CCRL2, IL1RAPL2, CXCR5), proinflammatory cytokines (IL12A, LTA), inflammatory mediator (PTAFR), complement protein C3, executioner protein of apoptosis (CASP7), growth factor (TGFA), colony stimulating factor (CSF-2), proteins involved in dendritic cells differentiation and interaction (CD209, LAMP3), regulation of immune response (LILRB2, LILBRB4).
Deciphering the message broadcast by tumor-infiltrating dendritic cells.
Tel et al., Nijmegen, Netherlands. In Am J Pathol, 2012
The activation status of DCs is based on the expression of CD83, DC-SIGN, and DC-LAMP, which are nonspecific markers of DC maturation.
[K-ras mutational status and tumour-infiltrating lymphocytes in human colon cancer: state of the art and future perspectives].
Fialová et al., United Kingdom. In Rozhl Chir, 2012
Tumour-infiltrating immune cells were detected by immunofluorescence staining using monoclonal antibodies against CD3, CD8, FoxP3, CD1a and DC-LAMP.
Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer.
Span et al., Nijmegen, Netherlands. In Cancer, 2011
In the current breast cancer cohorts, LAMP3 had independent prognostic value.
Significance of DC-LAMP and DC-SIGN expression in psoriasis vulgaris lesions.
Qing et al., Jinan, China. In Exp Mol Pathol, 2011
Both DC-LAMP and DC-SIGN proteins may be involved in the pathogenesis of psoriasis vulgaris.
Genetics of Parkinson's disease and essential tremor.
Zimprich, Vienna, Austria. In Curr Opin Neurol, 2011
RECENT FINDINGS: Within the last two years, genome-wide association (GWA) analyses have revealed a number of novel low-risk susceptibility variants for Parkinson's disease, among them HLA-DRB5, BST1, ACMSD, STK39, MCCC1/LAMP3, SYT11, and CCDC62/HIP1R) and have confirmed LINGO1 as risk factor for essential tremor.
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
Wood et al., In Lancet, 2011
Six were previously identified loci (MAPT, SNCA, HLA-DRB5, BST1, GAK and LRRK2) and five were newly identified loci (ACMSD, STK39, MCCC1/LAMP3, SYT11, and CCDC62/HIP1R).
Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells.
Hung et al., Beijing, China. In Virol J, 2010
LAMP3 is an influenza A virus inducible gene, and plays an important role in viral post-entry steps.
The surfactant lipid transporter ABCA3 is N-terminally cleaved inside LAMP3-positive vesicles.
Kern et al., München, Germany. In Febs Lett, 2010
Data show that the ABCA3 N-terminus is proteolytically removed inside acidic LAMP3-positive vesicles MVB/LB.
Increased expression of CD208 (DC-LAMP) in epidermal keratinocytes of psoriatic lesions.
Kawashima et al., Tokyo, Japan. In J Dermatol, 2009
Because a defect of the granular layer in psoriatic lesions has been recognized, increased expression of lysosome-related CD208 in the basal and suprabasal keratinocytes of psoriatic lesions might represent aberrant epidermal differentiation.
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