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DAZ associated protein 2

DAZAP2, PrtB, KIAA-0058, proline-rich transcript, brain-expressed, Proline-Rich Transcript in Brain
This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, HAD, metalloprotease, Noggin
Papers on DAZAP2
Maternal dazap2 Regulates Germ Granules by Counteracting Dynein in Zebrafish Primordial Germ Cells.
Marlow et al., United States. In Cell Rep, Aug 2015
Here, we show that the scaffold protein Dazap2 binds to Bucky ball, an essential regulator of oocyte polarity and GP assembly, and colocalizes with the GP in oocytes and in PGCs.
TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation.
Li et al., San Francisco, United States. In J Immunol, Apr 2015
Mechanistically, TRAF4 recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZAP2.
Regulation of microcystin-LR-induced toxicity in mouse spermatogonia by miR-96.
Han et al., Nanjing, China. In Environ Sci Technol, 2014
Deleted-in azoospermia-associated protein 2 (DAZAP2) was predicted to have a binding sequence for miR-96 within its 3'-untranslated region.
Discovery, identification and sequence analysis of RNAs selected for very short or long poly A tail in immature bovine oocytes.
Sirard et al., Québec, Canada. In Mol Hum Reprod, 2014
To further validate our methodology, we measured specific tail length of known candidates (AURKA, PTTG1, H2A1) but also determined the poly(A) tail length of other candidate RNAs (H3F3A, H1FOO, DAZAP2, ATF1, ATF2, KAT5, DAZL, ELAVL2).
Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival.
McBride et al., Galveston, United States. In Infect Immun, 2012
Eight target proteins, including translation elongation factor 1 alpha 1 (EF1A1), deleted in azoospermia (DAZ)-associated protein 2 (DAZAP2), ferritin light polypeptide (FTL), CD63, CD14, proteasome subunit beta type 1 (PSMB1), ring finger and CCCH-type domain 1 (RC3H1), and tumor protein p53-inducible protein 11 (TP53I11) interacted with TRP32 as determined by coimmunoprecipitation assays, colocalization with TRP32 in HeLa and THP-1 cells, and/or RNA interference.
Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2.
Gratchev et al., Mannheim, Germany. In Immunobiology, 2012
In summary we established a new mechanism of IL17RB regulation-Smurf2 dependent degradation of its adaptor protein DAZAP2.
The effects of promoter methylation on downregulation of DAZAP2 in multiple myeloma cell lines.
Hu et al., Changsha, China. In Plos One, 2011
Our previous studies had shown that DAZAP2 was profoundly downregulated in bone marrow mononuclear cells from multiple myeloma patients.
Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
Betel et al., New York City, United States. In Genes Dev, 2011
We show that in addition to its role in TGF-β signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1.
Evolutionary features and intracellular behavior of the PRTB protein.
Muto et al., Gifu, Japan. In Biochem Genet, 2011
Lys residues might play important roles in regulating the intracellular dynamics of the PRTB protein.K153 in human PRTB is essential for its ubiquitin-dependent degradation
Dazap2 is required for FGF-mediated posterior neural patterning, independent of Wnt and Cdx function.
Monsoro-Burq et al., Orsay, France. In Dev Biol, 2009
Here, we have identified a novel player, Dazap2, and show that it is required in vivo for posterior neural fate.
Dazap2 modulates transcription driven by the Wnt effector TCF-4.
Korinek et al., Praha, Czech Republic. In Nucleic Acids Res, 2009
In this report we reveal that the evolutionary conserved Dazap2 protein functions as a TCF-4 interacting partner.
Display of heterologous proteins on the surface of Lactococcus lactis using the H and W domain of PrtB from Lactobacillus delburueckii subsp. bulgaricus as an anchoring matrix.
Kim et al., South Korea. In J Appl Microbiol, 2008
AIMS: The aim of this study was to develop a cell-surface display system for foreign antigens on the surface of a Lactococcus lactis strain using an H and W domain of PrtB from Lactobacillus delburueckii subsp.
Molecular features and expression of DAZAP2 in human multiple myeloma.
Hu et al., Changsha, China. In Chin Med J (engl), 2007
DAZAP2 is downregulated in multiple myeloma samples and it may be a signal molecule in multiple myeloma cells. DAZAP2 is involved in the pathogenesis of MM
Analysis of the presence of prtR proteinase gene in natural isolates of Lactobacillus rhamnosus.
Jovanović et al., Belgrade, Serbia. In Folia Microbiol (praha), 2005
Compared with the other proteinases within the genus Lactobacillus (PrtP, PrtB and PrtH) which retained the activity in cell-free proteinase extracts, PrtR proteinase showed proteolytic activity only under in vivo conditions (whole cells of the producing strains).
The secretome of the plant pathogenic bacterium Erwinia chrysanthemi.
Hugouvieux-Cotte-Pattat et al., Villeurbanne, France. In Proteomics, 2004
In uninduced conditions, we identified spots corresponding to the cellulase Cel5, the proteases PrtA, PrtB, and PrtC, the flagellin FliC, and some intracellular proteins whose presence probably resulted from spontaneous cell lysis.
The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma.
Hu et al., In Genomics Proteomics Bioinformatics, 2004
The ORF of human DAZAP2 encodes a 17-kDa protein, which is highly similar to mouse Prtb.
Sox6 regulation of cardiac myocyte development.
Brilliant et al., Tucson, United States. In Nucleic Acids Res, 2003
This paper reveals that the mouse DAZAP2 homolog interacts with Sox6 and may be involved in the regulation of a cardiac L-type Ca2+ channel.
Proline-rich transcript of the brain (prtb) is a serum-responsive gene in osteoblasts and upregulated during adhesion.
Hadjiargyrou et al., Stony Brook, United States. In J Cell Biochem, 2001
role as an immediate early, serum-responsive, and adhesion-inducible gene with possible involvement in cell cycle control, adhesion, and proliferation
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