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DAZ associated protein 1

DAZAP1, mPrrp
In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DAZ, ACID, CAN, ERK, p13
Papers on DAZAP1
Exceptionally long 5' UTR short tandem repeats specifically linked to primates.
Ohadi et al., Tehrān, Iran. In Gene, Oct 2015
ZMYM3 and DAZAP1).
FUBP1: a new protagonist in splicing regulation of the DMD gene.
Tuffery-Giraud et al., Montpellier, France. In Nucleic Acids Res, Mar 2015
RNase-assisted pull down assay coupled with mass spectrometry revealed that the mutant RNA probe specifically recruits hnRNPA1, hnRNPA2/B1 and DAZAP1.
The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration.
Wang et al., Chapel Hill, United States. In Nat Commun, 2013
Here we show that DAZAP1, an RNA-binding protein involved in mammalian development and spermatogenesis, promotes inclusion of weak exons through specific recognition of diverse cis-elements.
DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts.
Yen et al., Taipei, Taiwan. In Nucleic Acids Res, 2013
Deleted in Azoospermia Associated Protein 1 (DAZAP1) is a ubiquitous heterogeneous nuclear ribonucleoprotein (hnRNP) that is expressed abundantly in the testis.
A genome-wide association study for reading and language abilities in two population cohorts.
Bates et al., Edinburgh, United Kingdom. In Genes Brain Behav, 2013
Suggestive association was indicated for reading measures and non-word repetition (NWR), with the greatest support found for single nucleotide polymorphisms (SNPs) in the pseudogene, ABCC13 (P = 7.34 × 10(-8)), and the gene, DAZAP1 (P = 1.32 × 10(-6)).
Differential translation of Dazap1 transcripts during spermatogenesis.
Yen et al., Taipei, Taiwan. In Plos One, 2012
Deleted in AZoospermia Associated Protein 1 (DAZAP1) is a ubiquitous hnRNP protein that has been implicated in RNA transcription, splicing, and translation.
Maternal stress induces epigenetic signatures of psychiatric and neurological diseases in the offspring.
Metz et al., Lethbridge, Canada. In Plos One, 2012
Furthermore, prenatal stress upregulated miR-219, which targets the gene Dazap1.
Transcription-dependent nuclear localization of DAZAP1 requires an N-terminal signal.
Yen et al., Taipei, Taiwan. In Biochem Biophys Res Commun, 2012
Deleted in Azoospermia Associated Protein 1 (DAZAP1) is a ubiquitous hnRNP protein required for normal development and spermatogenesis.
Acetylation of Prrp K150 regulates the subcellular localization.
Kurihara et al., Yokohama, Japan. In Gene, 2012
In this study, we report that deleted azoospermia associated protein 1 (DAZAP1)/proline-rich RNA binding protein (Prrp), a multifunctional RNA binding protein which is essential for spermatogenesis and normal cell growth, is acetylated at Lysine 150 within its RNA binding domain.
Expression of a Musashi-like gene in sexual and asexual development of the colonial chordate Botryllus schlosseri and phylogenetic analysis of the protein group.
Manni et al., Padova, Italy. In J Exp Zool B Mol Dev Evol, 2012
We here illustrate the characterization and expression pattern during both pathways of a transcript for a gene orthologous to Dazap1.
DAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation.
Gray et al., Edinburgh, United Kingdom. In Rna, 2011
DAZAP1 can regulate mRNA translation.
Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing.
Pagani et al., Trieste, Italy. In Plos One, 2010
Data show that hnRNPA1/A2, HuR and DAZAP1 splicing factors and DHX36 RNA helicase bind to the ISE, with hnRNPA1 acting negatively and DAZAP1 positively on splicing selection
A novel RNA-recognition-motif protein is required for premeiotic G1/S-phase transition in rice (Oryza sativa L.).
Kurata et al., Mishima, Japan. In Plos Genet, 2010
Rice MEL2 protein discovered in this study shows partial similarity with human proline-rich RRM protein, deleted in Azoospermia-Associated Protein1 (DAZAP1), though MEL2 also possesses ankyrin repeats and a RING finger motif.
DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins.
Rousseau et al., Dundee, United Kingdom. In Biochem Biophys Res Commun, 2009
The results suggest that DAZAP1 is a component of complexes that are crucial for the degradation and silencing of mRNA.
DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice.
Yen et al., Taipei, Taiwan. In Rna, 2008
DAZAP1 is not only essential for spermatogenesis, but also required for the normal growth and development of mice.
Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant.
Pagani et al., Trieste, Italy. In Mol Cell Biol, 2008
The binding of the splicing factors hnRNPA1/A2 and DAZAP1 is the primary determinant of T6 BRCA1 exon 18 exclusion.
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