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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Death-domain associated protein

Daxx, hDaxx
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] (from NCBI)
Top mentioned proteins: PML, CAN, RAD54, Histone, p53
Papers on Daxx
Neuroendocrine Tumor of the Pancreas as a Unique Manifestation of Cowden Syndrome: a Case Report.
Kebebew et al., Bethesda, United States. In J Clin Endocrinol Metab, Jan 2016
The germline DNA sequencing confirmed the clinical diagnosis of CS and revealed a PTEN mutation c.697C→T (p.R233*) causing a premature stop codon in exon 7. The tumor DNA sequencing showed no LOH or any copy number changes, and no other deleterious genetic alterations including those commonly mutated in sporadic pancreatic NETs; MEN1, ATRX, DAXX, TP53, and genes involved in the mTOR pathway.
Activation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1.
Chan et al., Kao-hsiung, Taiwan. In Pharmacol Ther, Dec 2015
Interestingly, the mechanistic targets of DJ-1 as an antioxidant, including Daxx, Nrf2, thioredoxin, glutathione, α-synuclein, PTEN/PI3K/Akt, and Pink/Parkin are also associated with those oxidative stress-related diseases.
Signal transducer and activator of transcription 3 regulation by novel binding partners.
Oritani et al., Sapporo, Japan. In World J Biol Chem, Dec 2015
This article reviews the roles of novel STAT3 binding partners such as DAXX, zipper-interacting protein kinase, Krüppel-associated box-associated protein 1, Y14, PDZ and LIM domain 2 and signal transducing adaptor protein-2, in the regulation of STAT3-mediated signaling.
Death Domain Associated Protein (Daxx), a Multi-Functional Protein.
Wu et al., In Cell Mol Biol Lett, Dec 2015
UNASSIGNED: Death domain associated protein (Daxx), a multi-functional protein, plays an important role in transcriptional regulation, cell apoptosis, carcinogenesis, anti-virus infection and so on.
PML/TRIM19-Dependent Inhibition of Retroviral Reverse-Transcription by Daxx.
Nisole et al., Paris, France. In Plos Pathog, Nov 2015
PML is mainly expressed in the nucleus, where it forms dynamic structures known as PML nuclear bodies that recruit many other proteins, such as Sp100 and Daxx.
Molecular mechanisms of activity and derepression of alternative lengthening of telomeres.
Reddel et al., Sydney, Australia. In Nat Struct Mol Biol, Nov 2015
This multistep process is facilitated by loss of the ATRX or DAXX chromatin-remodeling factors and by abnormalities of the telomere nucleoprotein architecture, including altered DNA sequence and decreased TRF2 saturation.
The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation.
Songyang et al., Guangzhou, China. In Cell Stem Cell, Oct 2015
Here we explore the processes involved by investigating the role of the chromatin factors Daxx and Atrx.
Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.
Banaszynski et al., Cambridge, United Kingdom. In Nature, Jul 2015
Deposition at a subset of these elements is dependent upon the H3.3 chaperone complex containing α-thalassaemia/mental retardation syndrome X-linked (ATRX) and death-domain-associated protein (DAXX).
The histone chaperone DAXX maintains the structural organization of heterochromatin domains.
Bazett-Jones et al., Toronto, Canada. In Epigenetics Chromatin, 2014
BACKGROUND: The death domain-associated protein (DAXX) collaborates with accessory proteins to deposit the histone variant H3.3 into mouse telomeric and pericentromeric repeat DNA.
The Role of Chemotherapy in Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors.
Pavel et al., Tampa, United States. In Front Horm Res, 2014
It will also be important to evaluate whether newly discovered mutations in pancreatic NETs, such as DAXX/ATRX, are associated with response to chemotherapy.
TERT promoter mutations are a rare event in gastrointestinal stromal tumors.
Saito et al., Tokyo, Japan. In Springerplus, 2014
Irregular telomerase activation can be maintained by TERT hot spot alterations and alternative lengthening of telomeres (ALT) characterized by inactivation of either the alpha-thalassemia/mental retardation syndrome X-linked (ATRX) or death domain-associated protein (DAXX).
TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner.
Gramberg et al., Erlangen, Germany. In Viruses, 2014
In this study, we analyzed the role of PML and the ND10 components Daxx and Sp100 during retroviral replication in different cell types.
Integrated genomic characterization of adrenocortical carcinoma.
Bertherat et al., Paris, France. In Nat Genet, 2014
We performed exome sequencing and SNP array analysis of 45 ACCs and identified recurrent alterations in known driver genes (CTNNB1, TP53, CDKN2A, RB1 and MEN1) and in genes not previously reported in ACC (ZNRF3, DAXX, TERT and MED12), which we validated in an independent cohort of 77 ACCs.
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.
Patel et al., New York City, United States. In Nature, 2012
DAXX is a metazoan histone chaperone specific to the evolutionarily conserved histone variant H3.3.
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors.
Matsukuma et al., Baltimore, United States. In Mod Pathol, 2012
These findings establish the existence of ATRX and DAXX defects and the alternative lengthening of telomeres phenotype in pancreatic neuroendocrine tumors in the context of MEN-1 syndrome
Interaction of dengue virus nonstructural protein 5 with Daxx modulates RANTES production.
Limjindaporn et al., Bangkok, Thailand. In Biochem Biophys Res Commun, 2012
This work demonstrates the interaction between DENV NS5 and Daxx and the role of the interaction on the modulation of RANTES production.
Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation.
Salomoni et al., London, United Kingdom. In Neuron, 2012
DAXX is associated with regulatory regions of selected activity-regulated genes, where it promotes H3.3 loading upon membrane depolarization. DAXX loss not only affects H3.3 deposition but also impairs transcriptional induction of these genes.
Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription.
Chung et al., Taipei, Taiwan. In J Biol Chem, 2012
Daxx, a HIPK kinase substrate in the apoptosis pathway, was phosphorylated by HIPK3 at Ser-669 in response to cAMP stimulation.
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.
Jabado et al., Montréal, Canada. In Nature, 2012
Mutations in ATRX (α-thalassaemia/mental retardation syndrome X-linked) and DAXX (death-domain associated protein), encoding two subunits of a chromatin remodelling complex required for H3.3 incorporation at pericentric heterochromatin and telomeres, were identified in 31% of samples overall, and in 100% of tumours harbouring a G34R or G34V H3.3 mutation.
Daxx interacts with and modulates the activity of CREB.
Shih et al., Taipei, Taiwan. In Cell Cycle, 2012
Depletion of endogenous Daxx by specific shRNA or overexpression of Daxx resulted in decreased or increased levels of the cAMP/PKA-induced reporter activity and target gene expression.
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