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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

TYRO protein tyrosine kinase binding protein

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: TREM2, CAN, V1a, DAP10, Syk
Papers on DAP12
Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases.
Buckner et al., Seattle, United States. In Immunol Rev, Jan 2016
This suggests that Lyp serves to downregulate a TLR inhibitory pathway in monocytes, and we propose that Lyp inhibits the TREM2/DAP12 inhibitory pathway.
Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain.
Basbaum et al., San Francisco, United States. In Nat Neurosci, Jan 2016
Downstream of CSF1R, we found that the microglial membrane adaptor protein DAP12 was required for both nerve injury- and intrathecal CSF1-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglial proliferation.
The triggering receptor expressed on myeloid cells 2 - a molecular link of neuroinflammation and neurodegenerative diseases.
Walter, Bonn, Germany. In J Biol Chem, Jan 2016
UNASSIGNED: The triggering receptor expressed on myeloid cells (TREM) 2 is a member of the immunoglobulin superfamily of receptors and mediates signaling in immune cells via engagement of its co-receptor DNAX activating protein of 12 kDa (DAP12).
Identification of crucial genes related to postmenopausal osteoporosis using gene expression profiling.
Cai et al., Shanghai, China. In Aging Clin Exp Res, Jan 2016
CONCLUSIONS: A series of interactions, such as CSTA/TYROBP, CCNE1/REL and TUBA1B/ESR1 might play pivotal roles in the occurrence and development of PMO.
Identification of a Novel Splice Variant Isoform of TREM-1 in Human Neutrophil Granules.
Klesney-Tait et al., Iowa City, United States. In J Immunol, Jan 2016
Humans have two forms of TREM-1: a membrane receptor, associated with the adaptor DAP12, and a soluble receptor detected at times of infection.
A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts.
Nakamura et al., Oklahoma City, United States. In Clin Rev Allergy Immunol, Dec 2015
Receptor activator for NF-κB ligand (RANKL or TNFSF11), a tumor necrosis factor (TNF) superfamily member, is the master cytokine required for osteoclastogenesis with essential co-stimulatory signals mediated by immunoreceptor tyrosine-based activation motif (ITAM)-signaling adaptors, DNAX-associated protein 12 kDa size (DAP12) and FcεRI gamma chain (FcRγ).
NKG2D Receptor and Its Ligands in Host Defense.
Lanier, San Francisco, United States. In Cancer Immunol Res, Jun 2015
In humans, NKG2D transmits signals by its association with the DAP10 adapter subunit, and in mice alternatively spliced isoforms transmit signals either using DAP10 or DAP12 adapter subunits.
The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective.
Humphrey et al., Oklahoma City, United States. In Res Rep Biochem, 2014
Here, we review the genetic causes of PLOSL with loss-of-function mutations or deletions in one of two genes, TYROBP and TREM2, encoding for two proteins DNAX-activating protein 12 (DAP12) and triggering receptor expressed on myeloid cells-2 (TREM2).
Small RNA Sequencing Uncovers New miRNAs and moRNAs Differentially Expressed in Normal and Primary Myelofibrosis CD34+ Cells.
Bortoluzzi et al., Florence, Italy. In Plos One, 2014
Target predictions of these validated small RNAs de-regulated in PMF and functional enrichment analyses highlighted many interesting pathways involved in tumor development and progression, such as signaling by FGFR and DAP12 and Oncogene Induced Senescence.
TREM2 in CNS homeostasis and neurodegenerative disease.
Bu et al., Jacksonville, United States. In Mol Neurodegener, 2014
The innate immune receptor and its adaptor protein—triggering receptor expressed on myeloid cells 2 (TREM2) and DNAX-activating protein of 12 kDa (DAP12)—possess the ability to modulate critical cellular functions via crosstalk with diverse signaling pathways.
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.
Emilsson et al., New York City, United States. In Cell, 2013
Through an integrative network-based approach, we rank-ordered these network structures for relevance to LOAD pathology, highlighting an immune- and microglia-specific module that is dominated by genes involved in pathogen phagocytosis, contains TYROBP as a key regulator, and is upregulated in LOAD.
Fyn positively regulates the activation of DAP12 and FcRγ-mediated costimulatory signals by RANKL during osteoclastogenesis.
Choi et al., Ch'ŏngju, South Korea. In Cell Signal, 2012
Fyn relays RANK/RANKL signal to the costimulatory DAP12/FcRgamma-mediated signals.
Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12).
Takeya et al., Ikoma, Japan. In J Biol Chem, 2012
the Siglec-15-DAP12-Syk-signaling cascade plays a critical role in functional osteoclast formation.
Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
Dissen et al., Oslo, Norway. In J Immunol, 2012
Because mouse and rat NKG2C and -E transmembrane regions contain a positively charged arginine residue located close to the extracellular surface, these receptors may not associate with DAP12.
Siglecs and immune regulation.
Mattoo et al., Boston, United States. In Annu Rev Immunol, 2011
This family also includes molecules involved in adhesion and phagocytosis and receptors that can associate with the ITAM-containing DAP12 adaptor.
Control of pathogenic CD4 T cells and lethal immunopathology by signaling immunoadaptor DAP12 during influenza infection.
Xing et al., Hamilton, Canada. In J Immunol, 2011
we report that the emergence of immunopathogenic CD4 T cells is under the control of a transmembrane immunoadaptor DAP12 pathway during influenza infection.
Involvement of the TREM-1/DAP12 pathway in the innate immune responses to Porphyromonas gingivalis.
Belibasakis et al., Zürich, Switzerland. In Mol Immunol, 2011
the putative periodontal pathogen P. gingivalis can positively regulate the expression of the TREM-1/DAP12 pathway in monocytic cells.
The structural basis for intramembrane assembly of an activating immunoreceptor complex.
Chou et al., Boston, United States. In Nat Immunol, 2010
Here we report the nuclear magnetic resonance (NMR) structure of the membrane-embedded, heterotrimeric assembly formed by association of the DAP12 signaling module with the natural killer (NK) cell-activating receptor NKG2C.
Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.
Ivashkiv et al., New York City, United States. In Immunity, 2010
Induction of inhibitors was dependent on a pathway composed of signaling molecules DAP12, Syk, and Pyk2 that coupled to downstream kinases p38 and MSKs and required integration of IL-10-dependent and -independent signals.
Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils.
Lo-Man et al., Paris, France. In Immunity, 2009
We show here that after bacterial stimulation, and in contrast to monocytes and macrophages, murine neutrophils contributed poorly to inflammatory responses; however, they secreted high amounts of the anti-inflammatory cytokine IL-10 in a DAP12 adaptor-Syk kinase and MyD88 adaptor-dependent manner.
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