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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Breast carcinoma amplified sequence 2

Top mentioned proteins: Meg, POLYMERASE, CAN, HAD, V1a
Papers on DAMI
Nonsteroidal anti-inflammatory drugs in-vitro and in-vivo treatment and Multidrug Resistance Protein 4 expression in human platelets.
Pulcinelli et al., Roma, Italy. In Vascul Pharmacol, Jan 2016
We evaluated MRP4-mRNA in a human megakacaryoblastic cell line (DAMI), treated with both COX-2 inhibitor (celecoxib) and traditional NSAIDs (diclofenac and naproxen).
CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes.
Newman et al., Milwaukee, United States. In Blood, Jan 2016
We employed CRISPR/Cas9 gene editing technology to transform Leu33-positive megakaryocyte-like DAMI cells and induced pluripotent stem (iPS) cells to the Pro33 allotype.
Maternal BCAS2 protects genomic integrity in mouse early embryonic development.
Li et al., Beijing, China. In Development, Dec 2015
BCAS2 (breast carcinoma amplified sequence 2), a core component of the PRP19 complex involved in pre-mRNA splicing, plays an important role in the DNA damage response through the RPA complex, a key regulator in the maintenance of genome integrity.
BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
Liu et al., Wuhan, China. In Int J Biochem Cell Biol, Nov 2015
BCAS2 was reported to be an essential subunit of pre-mRNA splicing complex.
BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability.
Chen et al., Taipei, Taiwan. In Br J Cancer, Feb 2015
BACKGROUND: We showed previously that breast carcinoma amplified sequence 2 (BCAS2) functions as a negative regulator of p53.
BCAS2 Regulates Delta-Notch Signaling Activity through Delta Pre-mRNA Splicing in Drosophila Wing Development.
Chen et al., Taipei, Taiwan. In Plos One, 2014
Previously, we showed that BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing.
Artificial MiRNA Knockdown of Platelet Glycoprotein lbα: A Tool for Platelet Gene Silencing.
Salles-Crawley et al., Kortrijk, Belgium. In Plos One, 2014
After in silico and in vitro screening of siRNAs targeting GPIbα (siGPIBAs), we developed artificial miRNAs (miGPIBAs), which were tested in CHO cells stably expressing GPIb-IX complex and megakaryoblastic DAMI cells.
Aspirin influences megakaryocytic gene expression leading to up-regulation of multidrug resistance protein-4 in human platelets.
Pulcinelli et al., Roma, Italy. In Br J Clin Pharmacol, 2014
METHODS: The effects induced by aspirin or PPARα agonist (WY14643) on MRP4 modulation were evaluated in vitro in a human megakaryoblastic DAMI cell line, in megakaryocytes (MKs) and in platelets obtained from human haematopoietic progenitor cell (HPC) cultures, and in vivo platelets obtained from aspirin treated healthy volunteers (HV).
[Effect of DNA methylation on the proliferation of leukemia cells regulated by miR-34b].
Chai et al., Suzhou, China. In Zhonghua Er Ke Za Zhi, 2014
METHOD: Taqman real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) was carried out to detect the relative expression of miR-34b in control group (bone marrow cells of 20 children without blood disease) and 8 leukemia cell lines (U937, HL-60, MV4-11, M2R, K562, Raji, CCRF, DAMI).
Common genetic variants on 1p13.2 associate with risk of autism.
Zhang et al., Changsha, China. In Mol Psychiatry, 2014
× 10(-8)), non-synonymous rs6537835 (P=3.26 × 10(-8)) and rs1877455 (P=8.70 × 10(-8)), and related haplotypes, AMPD1-NRAS-CSDE1, TRIM33 and TRIM33-BCAS2, associated with autism; all were mapped to a previously reported linkage region (1p13.2) with autism.
ERRβ signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells.
Mishra et al., Bhubaneshwar, India. In Br J Cancer, 2014
METHODS: Chromatin immunoprecipitation (ChIP) cloning of ERRβ transcriptional targets and gel supershift assays identified breast cancer amplified sequence 2 (BCAS2) and Follistatin (FST) as two important downstream genes that help to regulate tumourigenesis.
The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasia-mutated and Rad3-related (ATR).
Huang et al., Hangzhou, China. In J Biol Chem, 2014
The PSO4 core complex is composed of PSO4/PRP19/SNEV, CDC5L, PLRG1, and BCAS2/SPF27.
Crucial role for endoplasmic reticulum stress during megakaryocyte maturation.
Bobe et al., Le Kremlin-Bicêtre, France. In Arterioscler Thromb Vasc Biol, 2013
APPROACH AND RESULTS: Investigation of ER stress and maturation markers in different models of human thrombopoiesis (CHRF, DAMI, MEG-01 cell lines, and hematopoietic stem cells: CD34(+)) as well as in immature pathological platelets clearly indicated that ER stress occurs transiently during thrombopoiesis.
The Prp19 complex directly functions in mitotic spindle assembly.
Gruss et al., Heidelberg, Germany. In Plos One, 2012
Here we show that knockdown of the smallest subunit, BCAS2/Spf27, destabilizes the entire complex and leads to specific mitotic defects in human cells.
Breast cancer amplified sequence 2, a novel negative regulator of the p53 tumor suppressor.
Chen et al., Taipei, Taiwan. In Cancer Res, 2010
BCAS2 directly interacts with p53 to reduce p53 transcriptional activity by mildly but consistently decreasing p53 protein in the absence of DNA damage. In the presence of DNA damage, BCAS2 prominently reduces p53 protein.
Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2.
Zhu et al., Chicago, United States. In Biochem Biophys Res Commun, 2005
This study suggested that BCAS2 might play an important role in breast cancer development by increasing the estrogen receptor's function.
Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer.
Nagasaki et al., Kiel, Germany. In Cancer Lett, 2002
The BCAS2 gene was amplified in two of 60 primary breast cancer tissues, but not in other cancer cells, providing the first evidence of amplification within this region and indicating that BCAS2 gene codes for a nuclear protein.
Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'gamma)2 antibody.
Samulski et al., Chapel Hill, United States. In Nat Biotechnol, 1999
Targeted AAV vectors were able to transduce megakaryocyte cell lines, DAMI and MO7e, which were nonpermissive for normal AAV infection, 70-fold above background and at levels equivalent to permissive K562 cells.
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