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Dachshund 2

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008] (from NCBI)
Top mentioned proteins: DAC, Six1, CAN, SET, Myogenin
Papers on Dach2
Dach2-Hdac9 signaling regulates reinnervation of muscle endplates.
Goldman et al., Ann Arbor, United States. In Development, Jan 2016
Dach2 and Hdac9 are activity-regulated transcriptional co-repressors that are highly expressed in innervated muscle and suppressed following muscle denervation.
Prospective validation of DACH2 as a novel biomarker for prediction of metastasis and prognosis in muscle-invasive urothelial carcinoma of the bladder.
Li et al., Guangzhou, China. In Biochem Biophys Res Commun, May 2015
The role of Dachshund homolog 2 gene (DACH2) in tumorigenesis remains unexplored.
Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary.
Vainio et al., Oulu, Finland. In Exp Cell Res, Apr 2015
We used the Wnt-4 deficient mouse as a model to identify candidate gonadogenesis genes, and found that the Notum, Phlda2, Runx-1 and Msx1 genes are typical of the wild-type ovary and the Osr2, Dach2, Pitx2 and Tacr3 genes of the testis.
HDAC4-myogenin axis as an important marker of HD-related skeletal muscle atrophy.
Bates et al., London, United Kingdom. In Plos Genet, Mar 2015
In addition, HD mouse models develop a significant reduction in muscle force, possibly as a result of a deterioration in energy metabolism and decreased oxidation that is accompanied by the re-expression of the HDAC4-DACH2-myogenin axis.
Functional heterogeneity of PAX5 chimeras reveals insight for leukemia development.
Strehl et al., Vienna, Austria. In Mol Cancer Res, 2014
To gain mechanistic insight into the role of PAX5 fusion proteins in leukemogenesis, the biochemical and functional properties of uncharacterized fusions: PAX5-DACH1, PAX5-DACH2, PAX5-ETV6, PAX5-HIPK1, and PAX5-POM121 were ascertained.
Multi-tissue omics analyses reveal molecular regulatory networks for puberty in composite beef cattle.
Thomas et al., Davis, United States. In Plos One, 2013
A sub-network from this process revealed key transcriptional regulators (i.e., PITX2, FOXA1, DACH2, PROP1, SIX6, etc.).
Exome sequencing identifies mutations in ABCD1 and DACH2 in two brothers with a distinct phenotype.
Dai et al., Kunming, China. In Bmc Med Genet, 2013
However, exome sequencing revealed novel mutations in the ATP-binding cassette, sub-family D member 1 (ABCD1) and Dachshund homolog 2 (DACH2) genes in both brothers.
Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes.
Goldman et al., Rochester, United States. In Cell Rep, 2013
A core set of genes and pathways was substantially dysregulated in A2B5+ TPCs, which included the transcription factor SIX1 and its principal cofactors, EYA1 and DACH2.
Inferring the in vivo cellular program of developing bovine skeletal muscle from expression data.
Dalrymple et al., Australia. In Gene Expr Patterns, 2013
A set of TFs (SIX1, EYA2 and DACH2) considered important in undifferentiated murine cells were equally abundant in differentiated bovine cells.
Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice.
Kostek et al., Columbia, United States. In J Physiol Sci, 2012
Six1 is a transcription factor that, along with cofactors (Eya1, Eya3, and Dach2), regulates skeletal muscle fiber-type and development.
Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer.
Jirström et al., Lund, Sweden. In J Ovarian Res, 2011
BACKGROUND: The Dachshund homolog 2 (DACH2) gene has been implicated in development of the female genital tract in mouse models and premature ovarian failure syndrome, but to date, its expression in human normal and cancerous tissue remains unexplored.
Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study.
Broccardo et al., Toulouse, France. In Blood, 2010
Recurrent and novel fusion partners were identified, including NCoR1, DACH2, GOLGA6, and TAOK1 genes showing the high variability of the partners.
A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression.
Goldman et al., Ann Arbor, United States. In Mol Biol Cell, 2009
HDAC4 mediates gene induction indirectly by suppressing the expression of Dach2 and MITR that function as myogenin gene corepressors.
Mouse Dach1 and Dach2 are redundantly required for Müllerian duct development.
Mardon et al., New York City, United States. In Genesis, 2008
With Dach1, may redundantly control female reproductive tract formation by regulating expression of target genes required for development of the Mullerian duct.
The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming.
Yao et al., Durham, United States. In J Biol Chem, 2007
HDAC4 is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2, myogenin, and nAChR
Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade.
Goldman et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2006
a HDAC-Dach2-myogenin signaling pathway has been identified to decode nerve activity and control muscle gene expression in developing and adult skeletal muscle
Mouse Dach2 mutants do not exhibit gross defects in eye development or brain function.
Mardon et al., Houston, United States. In Genesis, 2006
Unlike Drosophila dachshund mutants that lack eyes and exhibit leg truncations, the eyes and limbs of Dach double mutants are present, suggesting differences between Dach and dachshund gene function during embryonic eye and limb formation.
Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes.
Zinn et al., Dallas, United States. In Cytogenet Genome Res, 2001
Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes. Only one of the six breakpoints disrupts a gene, DACH2.
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