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F-box and WD repeat domain containing 4

DAC, DACH, Dach1
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, Histone, HAD, V1a
Papers on DAC
The DACH/EYA/SIX gene network and its role in tumor initiation and progression.
Wu et al., Wuhan, China. In Int J Cancer, Apr 2016
Recent studies demonstrated that aberrant expressions of RDGN components in vertebrates, mainly Dach, Six, and Eya, represent a novel tumor signal.
Immunohistochemistry of ductal adenocarcinoma of the prostate and adenocarcinomas of non-prostatic origin: a comparative study.
Egevad et al., Stockholm, Sweden. In Apmis, Feb 2016
UNASSIGNED: Ductal adenocarcinoma of the prostate (DAC) has morphological similarities to adenocarcinomas of other organs.
A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity.
Volkan et al., Durham, United States. In Plos Genet, Jan 2016
Here, we show that Rn, along with BarH1/H2 (Bar), Bric-à-brac (Bab), Apterous (Ap) and Dachshund (Dac), constitutes a transcription factor (TF) network that patterns the developing olfactory tissue.
Low concentrations of 5-aza-2'-deoxycytidine induce breast cancer stem cell differentiation by triggering tumor suppressor gene expression.
Pham et al., Thành phố Hồ Chí Minh, Vietnam. In Onco Targets Ther, Dec 2015
We have examined the effects of 5-aza-2'-deoxycytidine (DAC) on BCSC differentiation.
Digitally controlled feedback for DC offset cancellation in a wearable multichannel EMG platform.
Benini et al., In Conf Proc Ieee Eng Med Biol Soc, Aug 2015
The proposed AFE solution has an internal Digital to Analog Converter (DAC) used to adjust independently the reference of each channel removing any DC offset.
A critical appraisal of daclizumab use as emerging therapy in multiple sclerosis.
Patti et al., Ulm, Germany. In Expert Opin Drug Saf, Jul 2015
INTRODUCTION: Daclizumab (DAC) is a mAb that binds to CD25, a receptor on the surface of lymphocytes for IL-2, a chemical messenger in the immune system.
Digging deep into "dirty" drugs - modulation of the methylation machinery.
Greil et al., Salzburg, Austria. In Drug Metab Rev, May 2015
The HMAs 5-azacitidine (AZA) and 2'-deoxy-5-azacitidine (decitabine, DAC) inhibit DNA methylation and have shown significant clinical benefits in patients with myeloid malignancies.
[Cyclic diadenosine monophosphate--a new second messenger in bacteria--a review].
Sun et al., In Wei Sheng Wu Xue Bao, Mar 2015
The level of c-di-AMP in bacteria is regulated by the activities of diadenylate cyclase (DAC) and phosphodiesterases (PDE) , the former harbors a DisA_N domain, and the latter a DHH or DHH/DHHA1 domain.
High Pressure Macromolecular Crystallography.
Watanabe, Nagoya, Japan. In Subcell Biochem, 2014
In recent years, significant development in high-pressure macromolecular crystallography (HPMX) using a diamond anvil cell (DAC) has been performed in combination with shorter wavelength X-ray of synchrotron radiation.
Genetic parameters and mapping quantitative trait loci associated with tibia traits in broilers.
Munari et al., Jaboticabal, Brazil. In Genet Mol Res, 2014
The gene DACH1 is located in this region; this gene acts to form the apical ectodermal ridge, responsible for limb development.
Bortezomib added to daunorubicin and cytarabine during induction therapy and to intermediate-dose cytarabine for consolidation in patients with previously untreated acute myeloid leukemia age 60 to 75 years: CALGB (Alliance) study 10502.
Larson et al., Boston, United States. In J Clin Oncol, 2013
PURPOSE: The purpose of this study was to determine remission induction frequency when bortezomib was combined with daunorubicin and cytarabine in previously untreated older adults with acute myeloid leukemia (AML) and safety of bortezomib in combination with consolidation chemotherapy consisting of intermediate-dose cytarabine (Int-DAC).
Genomic landscape of non-small cell lung cancer in smokers and never-smokers.
Wilson et al., Saint Louis, United States. In Cell, 2012
Novel alterations in genes involved in chromatin modification and DNA repair pathways were identified, along with DACH1, CFTR, RELN, ABCB5, and HGF.
DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1.
Lee et al., Taegu, South Korea. In Biochem Biophys Res Commun, 2012
The knockdown of DACH1 blocked the cell cycle progression of HL-60 promyeloblastic cells through the decrease of cyclin D1, D3, F, and Cdk 1, 4, and 6 and increase in p21(Cip1), which in turn decreased the phosphorylation of the Rb protein.
Increased expression of dachshund homolog 1 in ovarian cancer as a predictor for poor outcome.
Kong et al., Jinan, China. In Int J Gynecol Cancer, 2012
DACH1 is highly expressed in metastatic ovarian cancer compared with that of normal, benign, and borderline ovarian tissues and could play an important role in cancer growth.
Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression.
Nishimura et al., Kōbe, Japan. In Proc Natl Acad Sci U S A, 2012
mammalian homolog of Dac, Dach1/2, facilitated the action of Pax6 on expression of islet hormone genes in cultured mammalian cells. These observations indicate the conserved role of Dac/Dach in controlling insulin expression in conjunction with Ey/Pax6
Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine.
Yokoi et al., Kanazawa, Japan. In Biochem Pharmacol, 2012
human AADAC was the enzyme responsible for the deacetylation of rifamycins and would affect the induction rate of drug-metabolizing enzymes by rifamycins and their induced hepatotoxicity.
Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.
Aburatani et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2011
DACH1 is a distinctive tumor suppressor, which not only suppresses growth of tumor cells but also regulates bFGF-mediated tumor-initiating activity of glioma cells
New loci associated with kidney function and chronic kidney disease.
Fox et al., Baltimore, United States. In Nat Genet, 2010
Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3).
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis.
Rosenfeld et al., Los Angeles, United States. In Nature, 2003
The phosphatase function of Eya switches the function of Six1-Dach from repression to activation, causing transcriptional activation through recruitment of co-activators
Tissue-specific regulation of retinal and pituitary precursor cell proliferation.
Rosenfeld et al., San Diego, United States. In Science, 2002
Six6, in association with Dach corepressors, regulates proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter.
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