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Leiomodin 1

D-1, 1-d, 64 kD
The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, ACID, Phosphogluconate Dehydrogenase, CAN, fibrillin-1
Papers on D-1
Early Detection of Kawasaki Disease in Infants.
Lee et al., Kyŏngju, South Korea. In Korean Circ J, Nov 2015
SUBJECTS AND METHODS: We retrospectively reviewed the medical records of 64 KD patients from January 2010 to October 2014.
[Cloning, prokaryotic expression, and functional identification of a sesquiterpene synthase gene (AsSS4) from Aquilaria sinensis].
Liu et al., In Yao Xue Xue Bao, 2014
Recombinant AsSS4 protein was obtained after induction by IPTG and SDS-PAGE analysis with a MW of 64 kD.
Liquid chromatography-mass spectrometry and chemometric analysis of Ricinus communis extracts for cultivar identification.
Bourne et al., Australia. In Phytochem Anal, 2014
INTRODUCTION: Seeds of Ricinus communis contain the toxic protein ricin, a 64 kD heterodimeric type II ribosome-inactivating protein that has been used in several high-profile poisoning incidents.
Comparison of enzymatic activity of two linoleic acid isomerases expressed in E. coli.
Fan et al., Harbin, China. In Mol Biol Rep, 2013
LA isomerases were found expressed in E. coli, and the molecular weight was 64 KD for C12 LA isomerase and 55 KD for C9 LA isomerase.
Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells.
Miano et al., Rochester, United States. In J Biol Chem, 2012
Lmod1 is a new SMC-restricted SRF/MYOCD target gene.
Knockdown of Bardet-Biedl syndrome gene BBS9/PTHB1 leads to cilia defects.
Swaroop et al., Bethesda, United States. In Plos One, 2011
Human BBS9 mRNA rescues bbs9 knockdown phenotype in the zebrafish.
[The adjuvant effect of chimeric flagellin fliC/esat].
Jiao et al., Yangzhou, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011
RESULTS: The results showed that the proteins of fliC/esat and ESAT-6 were expressed solubly, with the sizes of 64 kD and 39 kD respectively.
Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts.
Chung et al., Seoul, South Korea. In Exp Mol Med, 2010
We found that tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) expression and active form MMP-2 (64 kD) were dose-dependently increased by methyl-beta-cyclodextrin (MbetaCD), a cholesterol depletion agent.
Modulation of type I iodothyronine 5'-deiodinase activity in white adipose tissue by nutrition: possible involvement of leptin.
Kopecký et al., Praha, Czech Republic. In Physiol Res, 2009
Results demonstrate changes in D1 activity in white adipose tissue under conditions of changing adiposity, and a stimulatory effect of leptin on D1 activity in the tissue.
Life without thyroxine to 3,5,3'-triiodothyronine conversion: studies in mice devoid of the 5'-deiodinases.
St Germain et al., United States. In Endocrinology, 2009
D1 playing an important role in iodide conservation by serving as a scavenger enzyme in peripheral tissues and the thyroid.
Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation.
Kochanek et al., Pittsburgh, United States. In Resuscitation, 2008
Densitometric analysis of the major 64 kD band showed that nitration and PARP activation were significantly increased in hippocampus, cortex and striatum in the 75 min EPR group vs. other groups.
Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9.
Sakai et al., Tokyo, Japan. In Mol Cell Biol, 2008
HNF4alpha regulates thyroid hormone homeostasis through transcriptional regulation of the Dio1 gene with GATA4 and KLF9
Functional definition of outer membrane proteins involved in preprotein import into mitochondria.
Whelan et al., Australia. In Plant Cell, 2007
Three outer membrane proteins of Arabidopsis thaliana mitochondria were studied: TOM20 (translocase of the outer mitochondrial membrane), METAXIN, and mtOM64 (outer mitochondrial membrane protein of 64 kD).
[Graves' disease (clinical aspects of Graves' disease)].
Iitaka, Saitama, Japan. In Nihon Rinsho, 1999
Patients with ophthalmopathy may have antibodies to 64 kD/55 kD external orbital muscle proteins.
Biochemical and molecular characterization of neurofibrillary degeneration in frontotemporal dementias.
Delacourte, Lille, France. In Dement Geriatr Cogn Disord, 1998
In Pick's disease the phosphorylated tau from Pick bodies are made of two major components (tau 55, 64 kD) and a minor 69 kD resulting from the lack of tau isoforms with the translated exon 10 (E10-).
The ocular muscle cell is a target of the immune system in endocrine ophthalmopathy.
Wall et al., Warsaw, Poland. In Int Arch Allergy Immunol, 1995
Although the primary EM antigen(s) recognized by immunocompetent cells and autoantibodies has not been definitely identified, some good candidates, among them a membrane antigen of 64 kD which is also expressed in the thyroid, have been partially characterized.
β-endorphin binding in cultured adrenal cortical cells.
Parker et al., Long Beach, United States. In Endocrine, 1995
Molecular cross linking experiments reveal putative receptor subunits of 85 kD, 64 kD, 54 kD and 44 kD.
Islet cell autoantigens in insulin-dependent diabetes.
Maclaren et al., Gainesville, United States. In J Clin Invest, 1993
One interesting observation that may have potential pathogenic implications is the observation that of all islet cell autoantigens described, only two (i.e., 64 kD/GAD, 38 kD) are reactive in their native configurations, implying that recognition of conformational epitopes is most important.
[Autoantigens in type-I diabetes].
Federlin et al., Gießen, Germany. In Immun Infekt, 1991
64 kD molecular weight, have been identified.
Heat-shock protein 65 as a beta cell antigen of insulin-dependent diabetes.
Duff et al., Edinburgh, United Kingdom. In Lancet, 1990
The primary beta-cell antigen of insulin-dependent diabetes is thought to be a protein with a molecular weight of approximately 64 kD.
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