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Interleukin 18 receptor 1

Cytokine Receptor, IL-18R
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-18, IFN-gamma, CAN, IL-1beta, IL-12
Papers on Cytokine Receptor
Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine.
Mika et al., Spain. In Mol Cell Neurosci, Feb 2016
We have studied the changes in the mRNA and protein levels (qRT-PCR and Western blot analysis, respectively) of IL-18, IL-18-binding protein (IL-18BP) and the IL-18 receptor (IL-18R) over time in rats following chronic constriction injury (CCI) of the sciatic nerve.
The role of osteoclast differentiation and function in skeletal homeostasis.
Takeshita et al., Ōbu, Japan. In J Biochem, Jan 2016
Osteoclast biology shares many features and components with cells of the immune system, including cytokine-receptor interactions (RANKL-RANK), intracellular signalling molecules (TRAF6) and transcription factors (NFATc1).
A novel machine learning method for cytokine-receptor interaction prediction.
Zhao et al., Harbin, China. In Comb Chem High Throughput Screen, Dec 2015
The cytokine-receptor interaction is one of the most important protein-protein interactions.
Single Nucleotide Polymorphism of Interleukin-18 and Interleukin-18 Receptor and the Risk of Papillary Thyroid Cancer.
Hong et al., Seoul, South Korea. In Exp Clin Endocrinol Diabetes, Nov 2015
In this study, we evaluated whether IL-18 and IL-18 receptor (IL-18R) polymorphisms are associated with the development and clinicopathological features of papillary thyroid carcinoma (PTC).
Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.
Hermanns, Würzburg, Germany. In Cytokine Growth Factor Rev, Oct 2015
This review summarizes aspects of cytokine transcription and biosynthesis, cytokine-receptor interactions, cross-species activities, signal transduction and physiology delineated from recent findings in genetic mouse models for both cytokines, OSM and IL-31.
The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator.
Siegel et al., Bethesda, United States. In J Leukoc Biol, Sep 2015
Genetic deficiency or blockade of TL1A-DR3 has defined a number of disease states that depend on this cytokine-receptor pair, whereas excess TL1A leads to allergic gastrointestinal inflammation through stimulation of group 2 innate lymphoid cells.
The βc receptor family - Structural insights and their functional implications.
Parker et al., Australia. In Cytokine, Aug 2015
The crystal structures of the GM-CSF ternary complex, the IL-5 binary complex and the very recent IL-3 receptor alpha subunit build upon decades of structure-function studies, giving new insights into cytokine-receptor specificity and signal transduction.
Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP.
Ferrini et al., Genova, Italy. In J Leukoc Biol, Apr 2015
This review will summarize the biology of the IL-18/IL-18R/IL-18BP system and will address the role of IL-18 and its inhibitor, IL-18BP, in cancer biology and immunotherapy.
Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.
Garcia et al., Stanford, United States. In Sci Signal, 2014
Cytokines dimerize cell surface receptors to activate signaling and regulate many facets of the immune response.
Insights into cytokine-receptor interactions from cytokine engineering.
Garcia et al., Stanford, United States. In Annu Rev Immunol, 2014
However, the desired immunotherapeutic effects of native cytokines are often mitigated by toxicity or lack of efficacy, either of which results from cytokine receptor pleiotropy and/or undesired activation of off-target cells.
T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R.
Johansson et al., London, United Kingdom. In Sci Rep, 2014
Pattern recognition receptors (PRRs) and cytokine receptors are key players in the initiation of immune responses to infection.
A role for the ITAM signaling module in specifying cytokine-receptor functions.
Medzhitov et al., New Haven, United States. In Nat Immunol, 2014
Diverse cellular responses to external cues are controlled by a small number of signal-transduction pathways, but how the specificity of functional outcomes is achieved remains unclear.
Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells.
McSorley et al., Davis, United States. In Immunity, 2014
Further, maximal stimulation of Th1 cells by lipopolysaccharide (LPS) did not require T-cell-intrinsic expression of toll-like receptor 4 (TLR4), interleukin-1 receptor (IL-1R), or interferon-γ receptor (IFN-γR) but instead required IL-18R, IL-33R, and adaptor protein MyD88.
Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis.
Perry et al., Bristol, United Kingdom. In Int J Immunogenet, 2012
Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with knee osteoarthritis.
IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants.
Thomas et al., State College, United States. In Pediatr Res, 2012
Data suggest that IL-18RAP and IL-18R1 single-nucleotide polymorphisms identify African-American infants at risk for bronchopulmonary dysplasia.
Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.
Dong et al., Houston, United States. In Immunity, 2011
Thus, our work has identified a cytokine-receptor pair with important function in regulating proinflammatory responses.
Interleukin-18 and interleukin-18 receptor-α expression in allergic asthma.
O'Byrne et al., In Eur Respir J, 2011
IL18 and its receptor may play an important role in the pathogenesis of allergic asthma.
Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African Americans.
Poland et al., Rochester, United States. In J Infect Dis, 2011
IL18 and IL18R1 genes as plausible genes regulating the humoral immune response to smallpox vaccine in both Caucasians and African Americans.
Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis.
Aizawa et al., Kurume, Japan. In Arthritis Res Ther, 2010
The soluble IL-18Ralpha complex could be a potentially useful biomarker for the diagnosis of rheumatoid arthritis
Structural insights into the assembly and activation of IL-1β with its receptors.
Wang et al., Beijing, China. In Nat Immunol, 2010
Our results provide a structural basis for assembly and activation of the IL-1 receptor and offer a general cytokine-receptor architecture that governs the IL-1 family of cytokines.
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