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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Keratin 18

cytokeratin 18, CK18, K18, keratin 18
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, CAN, HAD, cytokeratin 19, PrP
Papers using cytokeratin 18 antibodies
Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline
Wells A et al., In British Journal of Cancer, 2004
... The primary antibodies used were mouse monoclonal antibodies selective for human E-cadherin, human cytokeratin 18 and human-specific controls tubulin (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.
Bielenberg Diane Renee, In PLoS ONE, 2003
... Biotech Ltd); anti-CD44v6 (directly conjugated with allophycocyanin (APC), clone C44-26, BD Pharmingen); anti-Cytokeratin 5 (clone RCK103, Santa-Cruz),anti-Cytokeratin 18 (clone E431-1, Epitomics), donkey anti-rabbit and sheep ...
RNA binding protein sex-lethal (Sxl) and control of Drosophila sex determination and dosage compensation
Ko Lan et al., In Nucleic Acids Research, 2002
... Alu sequence involvement in transcriptional insulation of the keratin 18 gene in transgenic mice ...
Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors
Weaver Valerie M. et al., In The Journal of Cell Biology, 2002
... 25, and NFκB p65, rabbit sera (Santa Cruz Biotechnology, Inc.) and clone 20 (BD Biosciences); cytokeratin 18, clone RCK106 (BD Biosciences); RAC1, clone 102 (BD ...
Papers on cytokeratin 18
Global profiling of the signaling network of papillary thyroid carcinoma.
Zhang et al., New York City, United States. In Life Sci, Feb 2016
KEY FINDINGS: 11 were differentially expressed between tumors and surrounding tissues, 8 of which were up-regulated (cytokeratin 18, Stat 1, HMG-1, p-p70 S6 kinase, Raf-B, glutamine synthetase, p-PKC δ, and HDAC1), while 3 of which were down-regulated (cytokeratin 5, BECN1, and p-ERK).
Characterization of swine testicular cell line as immature porcine Sertoli cell line.
Li et al., Wuhan, China. In In Vitro Cell Dev Biol Anim, Feb 2016
Then ST cells were further confirmed to be immature Sertoli cells by examining the expression of three markers (anti-Mullerian hormone, AMH; keratin 18, KRT18; follicle-stimulating hormone receptor, FSHR).
Improvement in non-alcoholic fatty liver disease severity is associated with a reduction in carotid intima-media thickness progression.
Byrne et al., Southampton, United Kingdom. In Atherosclerosis, Jan 2016
METHODS: In a pre-specified sub-study of the WELCOME (Wessex Evaluation of fatty Liver and Cardiovascular markers in NAFLD with OMacor thErapy) trial (NCT00760513), CIMT was measured using B-mode ultrasound while NAFLD severity was assessed by measuring liver fat percentage (magnetic resonance spectroscopy) and hepatic necro-inflammation (serum cytokeratin-18 (CK-18) concentration), at baseline and end of study.
Can widely used cell type markers predict the suitability of immortalized or primary mammary epithelial cell models?
Albrecht et al., Bern, Switzerland. In Biol Res, Dec 2015
The stain index (based on flow cytometry) of CK7 and CK19 protein was lower (P < 0.05) in MAC-T than in bMECs, while the expression of α-SMA and CK18 showed an inverse pattern.
A liver-on-a-chip platform with bioprinted hepatic spheroids.
Khademhosseini et al., Boston, United States. In Biofabrication, Dec 2015
The engineered hepatic construct remained functional during the 30 days culture period as assessed by monitoring the secretion rates of albumin, alpha-1 antitrypsin, transferrin, and ceruloplasmin, as well as immunostaining for the hepatocyte markers, cytokeratin 18, MRP2 bile canalicular protein and tight junction protein ZO-1.
The Art and Science of Diagnosing and Managing Drug-induced Liver Injury in 2015 and Beyond.
Lewis, Colombia. In Clin Gastroenterol Hepatol, Nov 2015
Markers of necrosis and apoptosis such as microRNA-122 and keratin 18 may prove useful in identifying patients at risk for severe injury when they initially present with a suspected acetaminophen overdose.
Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature.
Campani et al., Pisa, Italy. In World J Gastroenterol, Oct 2015
Immunohistochemical studies revealed that the epithelial component was reactive for CK CAM5.2, CK8, CK18, CEA (polyclonal) and was focally positive for hepar-1 and that the lymphoid infiltrate was positive for CD3, CD4 and CD8.
Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18.
Capetanaki et al., Athens, Greece. In Nat Med, Sep 2015
The cardioprotective effects of TNF-α are a consequence of nuclear factor-κB (NF-κB)-mediated ectopic expression in cardiomyocytes of keratin 8 (K8) and keratin 18 (K18), two epithelial-specific intermediate filament proteins.
A comprehensive review of noninvasive liver fibrosis tests in pediatric nonalcoholic Fatty liver disease.
Alkhouri et al., Cleveland, United States. In Curr Gastroenterol Rep, Jun 2015
Advanced biochemical markers include biomarkers of hepatocyte cell death such as cytokeratin 18 fragment levels, and markers of extracellular matrix turnover such as the Enhanced Liver Fibrosis (ELF) test and hyaluronic acid.
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature.
Navarro et al., Houston, United States. In Ann Clin Lab Sci, 2014
Immunohistochemical stains showed the component of Sertoli cell differentiation was positive for cytokeratin 18 and inhibin.
Drug-induced liver injury: the dawn of biomarkers?
Kullak-Ublick et al., Zürich, Switzerland. In F1000prime Rep, 2014
Proposed DILI indicators that are under investigation include microRNAs, cytokeratin-18 (CK18), high mobility group box protein 1 (HMGB-1), and several other biomarkers.
Oxidative stress, Nrf2 and keratin up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria.
Omary et al., Ann Arbor, United States. In Hepatology, 2012
Oxidative stress, Nrf2 and keratin 18 up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria
Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.
Denk et al., Graz, Austria. In Lab Invest, 2012
Keratin 8 and keratin 18 mice on the same genetic background show similar sensitivity to DDC intoxication.
Bromelain-induced apoptosis in GI-101A breast cancer cells.
Rathinavelu et al., Fort Lauderdale, United States. In J Med Food, 2012
A dose-dependent increase in the activities of caspase-9 and caspase-3 coinciding with elevation of CK18 levels was found in bromelain-treated breast cancer cells.
Non-coding keratin variants associate with liver fibrosis progression in patients with hemochromatosis.
Omary et al., Ulm, Germany. In Plos One, 2011
In patients with hemochromatosis, intronic but not exonic K8/K18 variants associate with liver fibrosis development.
Randomized phase II study of dulanermin in combination with paclitaxel, carboplatin, and bevacizumab in advanced non-small-cell lung cancer.
Blackhall et al., Villejuif, France. In J Clin Oncol, 2011
Of 161 available serum samples, a trend toward increased caspase-cleaved cytokeratin-18 was observed after dulanermin treatment in cycles 1 and 2. Among 84 patients evaluated for GalNT14 expression, there was a trend toward favorable progression-free survival and overall survival with dulanermin treatment in those with high GalNT14 expression.
The prognostic potential of keratin 18 in breast cancer associated with tumor dedifferentiation, and the loss of estrogen and progesterone receptors.
Kim et al., Seoul, South Korea. In Cancer Biomark, 2010
loss of cytokeratin 18 expression might be a good indicator of the poor prognosis of the breast cancer and it may play an active role in the breast tumorigenesis.
Stressing the role of O-GlcNAc: linking cell survival to keratin modification.
Coulombe et al., In Nat Cell Biol, 2010
Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.
Differential quantitative analysis of MHC ligands by mass spectrometry using stable isotope labeling.
Stevanovic et al., In Nat Biotechnol, 2004
Guanidination/nicotinylation was applied to keratin 18-transfected cells and resulted in the characterization of the peptide RLASYLDRV (HLA-A(*)0201), exclusively presented on the transfectant.
Minimal residual disease in gastric cancer: evidence of an independent prognostic relevance of urokinase receptor expression by disseminated tumor cells in the bone marrow.
Allgayer et al., München, Germany. In J Clin Oncol, 2002
PATIENTS AND METHODS: In 156 gastric cancer patients (prospective series), disseminated tumor cells in the bone marrow and the u-PAR expressed by these tumor cells were determined by cytokeratin (CK) 18 immunocytochemistry and u-PAR/CK18 double immunocytochemistry.
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