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Cytochrome P450, family 4, subfamily F, polypeptide 3

Cytochrome P-450
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: Cyp, ACID, CAN, HAD, V1a
Papers on Cytochrome P-450
Assessment of platelet-derived thrombogenicity by the total thrombus-formation analysis system in coronary artery disease patients on antiplatelet therapy.
Ogawa et al., Kumamoto, Japan. In J Thromb Haemost, Feb 2016
In the aspirin/clopidogrel group, the PL24 -AUC10 was higher in poor metabolizers (PM) with cytochrome P-450 2C19(CYP2C19) polymorphism (152±112, 95% CI, 103.4-200.6)
Combining cytochrome P-450 3A4 modulators and cyclosporine or everolimus in transplantation is successful.
Valjalo et al., Santiago, Chile. In World J Transplant, Jan 2016
Both groups also received tapering steroids, the cytochrome P-450 3A4 (CYP3A4) modulator, ketoconazole 50-100 mg/d, and cyclosporine with C0 targets in the everolimus group of 200-250 ng/mL in 1 mo, 100-125 ng/mL in 2 mo, and 50-65 ng/mL thereafter, and in the azathioprine or MMF group of 250-300 ng/mL in 1 mo, 200-250 ng/mL in 2 mo, 180-200 ng/mL until 3-6 mo, and 100-125 ng/mL thereafter.
Detection of carcinogenic etheno-DNA adducts in children and adolescents with non-alcoholic steatohepatitis (NASH).
Seitz et al., Heidelberg, Germany. In Hepatobiliary Surg Nutr, Dec 2015
In ALD εdA levels correlated significantly with cytochrome P-450 2E1 (CYP2E1) expression which is also induced in non-alcoholic steatohepatitis (NASH).
Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population.
Sokołowska-Wojdyło et al., Gdańsk, Poland. In Postepy Dermatol Alergol, Oct 2015
INTRODUCTION: The pathogenesis of acne is complex, multifactorial and not well understood.
Cobicistat: Review of a Pharmacokinetic Enhancer for HIV Infection.
Schafer et al., Philadelphia, United States. In Clin Ther, Oct 2015
FINDINGS: Cobicistat is a PK enhancer lacking antiviral activity that, via selective cytochrome P-450 (CYP) 3A inhibition, inhibits the metabolism of certain antiretroviral medications and is used for prolonging their effect.
Beneficial effects of ω-3 PUFA in children on cardiovascular risk factors during childhood and adolescence.
Fava et al., Verona, Italy. In Prostaglandins Other Lipid Mediat, Jul 2015
Mechanisms through which ω-3 FA act are manifolds and still a matter of investigation: beside their interaction with ion channel and their influence on plasma membrane fluidity, probably the main effect is acting as competitor for cytochrome P-450 (CYP) with respect to ω-6 FA.
Assessing pharmacologic and nonpharmacologic risks in candidates for kidney transplantation.
Trofe-Clark et al., Philadelphia, United States. In Am J Health Syst Pharm, Jun 2015
Key pharmacotherapy-related issues and considerations during the risk assessment process include (1) anticoagulation concerns, (2) cytochrome P-450 isoenzyme-mediated drug interactions, (3) mental health-related medication use, (4) chronic pain-related medication use, (5) medication allergies, (6) use of hormonal contraception and replacement therapy, (7) prior or current use of immunosuppressants, (8) issues with drug absorption, (9) alcohol use, (10) tobacco use, (11) active use of illicit substances, and (12) use of herbal supplements.
[Characterisation of selected molecular mechanisms influencing pharmacokinetics and pharmacodynamics of antidepressants].
Balcerczak et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2014
In the review the best known polymorphisms of selected genes encoding isoenzymes of cytochrome P-450, responsible for metabolism of popular antidepressant drugs, namely CYP2C19, CYP2D6, CYP1A2, and CYP3A4/5 are described.
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer.
Silva et al., São Paulo, Brazil. In Genet Mol Res, 2014
The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer.
An N-bridged high-valent diiron-oxo species on a porphyrin platform that can oxidize methane.
Sorokin et al., Villeurbanne, France. In Nat Chem, 2012
The catalytic properties of cytochrome P-450 and soluble methane monooxygenase enzymes are associated with oxo species on mononuclear iron haem and diiron non-haem platforms, respectively.
[Clinical significance of pharmacogenetics in psychiatry].
Rychlik-Sych et al., In Wiad Lek, 2012
Participation of cytochrome P-450 isoenzymes (including CYP1A2, CYP2C19, CYP2D6, CYP3A4) in the metabolism of psychotropic drugs contributes to risk of adverse interactions, both in pharmacokinetic and pharmacodynamic phase.
Human cytochrome P450 4F3: structure, functions, and prospects.
Salaün et al., Brest, France. In Drug Metabol Drug Interact, 2011
In this short review, emphasis will be placed on the regulation and the functional roles of human CYP4F3--{REVIEW}
LTB4 can stimulate human osteoclast differentiation dependent of RANKL.
Jiang et al., Beijing, China. In Artif Cells Blood Substit Immobil Biotechnol, 2009
can directly stimulate osteoclast differentiation dependent of RANKL
Cytochrome p-450 polymorphisms and response to clopidogrel.
Sabatine et al., Boston, United States. In N Engl J Med, 2009
BACKGROUND: Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect.
Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.
Amet et al., Brest, France. In J Lipid Res, 2008
Main fatty acid pathway is the omega-hydroxylation of polyunsaturated fatty acids.
CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis.
Plée-Gautier et al., Brest, France. In J Lipid Res, 2008
CYP4F3B is the key enzyme to produce 20-HETE by omega-hydroxylation of arachidonic acid in liver cells
Differential modulation of leukotriene B4 synthesis and degradation in human bronchoalveolar lavage cells by lipopolysaccharide and tobacco smoke.
Serio et al., Los Angeles, United States. In Cancer Prev Res (phila), 2008
By regulating the balance of LTB4 in the lung, LTB4OH may function as a suppressor of lung carcinogenesis.
Ruthenium catalyzed biomimetic oxidation in organic synthesis inspired by cytochrome P-450.
Zhang et al., Okayama, Japan. In Chem Soc Rev, 2008
Simulation of the function of cytochrome P-450 with low valent ruthenium complex catalysts leads to the discovery of biomimetic, catalytic oxidation of various substrates selectively under mild conditions.
Genetic determinants of response to warfarin during initial anticoagulation.
Stein et al., Nashville, United States. In N Engl J Med, 2008
BACKGROUND: Genetic variants of the enzyme that metabolizes warfarin, cytochrome P-450 2C9 (CYP2C9), and of a key pharmacologic target of warfarin, vitamin K epoxide reductase (VKORC1), contribute to differences in patients' responses to various warfarin doses, but the role of these variants during initial anticoagulation is not clear.
Monooxygenase Induction and Chlorobiphenyls in the Deep-Sea Fish Coryphaenoides armatus.
Farrington et al., In Science, 1986
Specific recognition of a protein by antibodies to P-450E in an immunoblot assay further indicated xenobiotic-induced cytochrome P-450 in these animals.
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